Professor Nicholas West

Associate Professor

School of Chemistry and Molecular Biosciences

+61 7 336 54093

n.west@uq.edu.au

View researcher profile

Primary research interest

Tuberculosis microbiology

About me

After completing my PhD in 2000, I began postdoctoral research at the University of Oxford, UK, and then later at the Imperial College London. During this time I spent significant time collaborating and working at the Institute Pasteur in Paris. In 2004 I returned to Australia as a postdoctoral scientist at the Centenary Institute in Sydney where I began researching tuberculosis. I moved to The University of Queensland as a senior Lecturer and Research Fellow in mid-2012.

Donate to tuberculosis research

Research focus and collaborations

Lab: tuberculosis research

My laboratory is committed to understanding the mechanisms by which Mycobacterium tuberculosis causes Tuberculosis (TB). One in three people in the world are infected with this bacterium, resulting in approximately 4,000 deaths every day. My lab utilises modern molecular genomic technologies to identify the genetic requirements for M. tuberculosis to cause TB. This information is being translated into the development of new therapies and control measures for TB. Research within the group will fall largely into one of the following three themes: Essential Gene Identification in M. tuberculosis, Understanding Latency and Targeted Drug Development.

National research collaborations

University of Sydney, School of Chemistry
University of Sydney, Sydney Medical School
University of Sydney, Faculty of Pharmacy
Centenary Institute, Mycobacterial Research Laboratory

International collaborations

National University of Singapore, Singapore
University of Oxford, UK

Funded projects

2007-2009: NHMRC - New Investigator Grant, Identification of Essential Components of Mycobacterium tuberculosis - $396,342
2011-2013: NHMRC- Project Grant, Genes to Drugs for TB - $702,165
2011-2014: NHMRC - Career Development Fellowship (level 2), Tuberculosis: Genes to Drugs - $424,902
2012-2013: UQ NSRSF Award, Characterisation of metabolic pathways in M. tuberculosis and the Development of Inhibitors - $12,000
2013-2015: NHMRC - Project Grant, Latent Tuberculosis Infection - $569,737
2013-2015: NHMRC- Project Grant, Improving subunit vaccines for tuberculosis for pulmonary delivery - $615,221

Teaching interests

Undergraduate

MICR3003, Molecular Microbiology (Course Co-ordinator)
MICR3001, Microbes and Human Health
BIOL2202/BIOL2902, Genetics/Advanced Genetics

Postgraduate coursework

MICR6008, Immunology and Infectious Diseases

Student supervision

For many years now there has been a constant presence of undergrad and postgrad research students in the group. Currently, I supervise students at all levels, ie. undergraduate research, Hons, MSc. and PhD. Enquiries from students regarding available positions are always welcome.

Achievements and awards

NHMRC Postdoctoral Reference Group Committee member (2012-)
NHMRC CDA2 Research Fellow (2011)
Centenary Institute “Innovation Award” (2010)
Australian Society of Microbiology NSW/ACT branch Executive (2010-2012)
Chair, Scientific Program; Australian Society of Microbiology National Conference, Brisbane (2018)

Featured publications

Tan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018) Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 6: e5146. doi:10.7717/peerj.5146
Strong, Emily J. and West, Nicholas P. (2018) Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 1: 5604. doi:10.1038/s41598-018-23893-3
Ng, Benjamin Y. C., Wee, Eugene J. H., Woods, Kyra, Anderson, Will, Antaw, Fiach, Tsang, Hennes Z. H., West, Nicholas P. and Trau, Matt (2017) Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosis. Analytical Chemistry, 89 17: 9017-9022. doi:10.1021/acs.analchem.7b01685
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 14414. doi:10.1038/ncomms14414
Ng, Benjamin Y. C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015) Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding. ACS Sensors, 1 2: 173-178. doi:10.1021/acssensors.5b00171

Publications by Nick West

Researcher biography

Associate Professor West is a molecular microbiologist, expert in bacterial pathogenesis. He is Head of "Tuberculosis Research" in the School of Chemistry and Molecular Biosciences, University of Queensland. Nick has a particular interest in drug development for TB. His research utilises modern molecular technologies to identify the genetic requirements for Mycobacterium tuberculosis to cause Tuberculosis (TB) with these genetic discoveries translated into novel antibiotic therapies. Research within his group falls largely into one of the following four themes: Essential Gene Identification in M. tuberculosis, Understanding TB Latency, Targeted TB Drug Development and Improving TB Vaccination.

Nick conducted postdoctoral research at the University of Oxford and Imperial College London. Returning to Australia in 2004, he spent several years at Sydney's Centenary Institute as an Associate Faculty member before relocating to University of Queensland in 2012. In addition to drug development, Nick's research portfolio includes programmes of vaccine and diagnostic development and testing.

Publications

Book Chapter (1)

Journal Articles (76)

Conference Paper (1)

Book Chapter

Ng, Benjamin Y.C., Wee, Eugene J.H., West, Nicholas P. and Trau, Matt (2019). Nucleic Acid Detection of Tuberculosis Via Innovative Point-of-Care Nanotechnologies Targeted for Low Resource Settings. Revolutionizing Tropical Medicine. (pp. 584-599) Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119282686.ch33

Journal Articles

Wang, XinYue, Jowsey, William J., Cheung, Chen-Yi, Smart, Caitlan J., Klaus, Hannah R., Seeto, Noon EJ, Waller, Natalie JE, Chrisp, Michael T., Peterson, Amanda L., Ofori-Anyinam, Boatema, Strong, Emily, Nijagal, Brunda, West, Nicholas P., Yang, Jason H., Fineran, Peter C., Cook, Gregory M., Jackson, Simon A. and McNeil, Matthew B. (2024). Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Nature Communications, 15 (1) 9791, 9791. doi: 10.1038/s41467-024-54072-w

Tran, Eric, Cheung, Chen‐Yi, Li, Lucy, Carter, Glen P., Gable, Robert W., West, Nicholas P., Kaur, Amandeep, Gee, Yi Sing, Cook, Gregory M., Baell, Jonathan B. and Jörg, Manuela (2024). Phenotypic‐Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis. ChemMedChem, e202400482. doi: 10.1002/cmdc.202400482

Phillips-Rose, Louis S., Yu, Chendi K., West, Nicholas P. and Fraser, James A. (2024). A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans. Journal of Fungi, 10 (8) 567, 567. doi: 10.3390/jof10080567

Pidot, Sacha J., Klatt, Stephan, Ates, Louis S., Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R., Porter, Jessica L., Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M., West, Nicholas, Tobias, Nicholas J., Fuerst, John A., Stutz, Michael D., Pellegrini, Marc, McConville, Malcolm, Brosch, Roland and Stinear, Timothy P. (2024). Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus. PLoS Pathogens, 20 (8) e1012440, e1012440. doi: 10.1371/journal.ppat.1012440

Strong, Emily J., Tan, Lendl, Hayes, Sasha, Whyte, Hayden, Davis, Rohan A. and West, Nicholas P. (2024). Identification of axinellamines A and B as anti-tubercular agents. Marine Drugs, 22 (7) 298. doi: 10.3390/md22070298

Churchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479

Stupar, Miljan, Tan, Lendl, Kerr, Edward D., De Voss, Christopher J., Forde, Brian M., Schulz, Benjamin L. and West, Nicholas P. (2024). TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection. Nature Communications, 15 (1) 1615, 1-14. doi: 10.1038/s41467-024-45343-7

Farr, Dylan C., Haselhorst, Thomas, Tan, Lendl, Furness, Juanelle, Strong, Emily, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2024). Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamides. European Journal of Medicinal Chemistry, 264 115983, 1-12. doi: 10.1016/j.ejmech.2023.115983

Prendergast, Kelly A., Nagalingam, Gayathri, West, Nicholas P. and Triccas, James A. (2024). Mycobacterium tuberculosis deficient in PdtaS cytosolic histidine kinase displays attenuated growth and affords protective efficacy against Aerosol M. tuberculosis infection in mice. Vaccines, 12 (1) 50, 50. doi: 10.3390/vaccines12010050

Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333

Farr, Dylan C., Tan, Lendl, Furness, Juanelle, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2023). Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin. Australian Journal of Chemistry, 76 (11), 812-820. doi: 10.1071/ch23154

Barbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Priebbenow, Daniel and Baell, Jonathan B. (2023). Discovery of anti‐tubercular analogues of bedaquiline with modified A‐, B‐ and C‐ring subunits. ChemMedChem, 18 (1) e202200533, e202200533. doi: 10.1002/cmdc.202200533

Ang, Chee Wei, Lee, Brendon M., Jackson, Colin J., Wang, Yuehong, Franzblau, Scott G., Francisco, Amanda F., Kelly, John M., Bernhardt, Paul V., Tan, Lendl, West, Nicholas P., Sykes, Melissa L., Hinton, Alexandra O., Bolisetti, Raghu, Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A.T. (2022). Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection. Journal of Medicinal Chemistry, 65 (19), 13125-13142. doi: 10.1021/acs.jmedchem.2c00972

Stupar, Miljan, Furness, Juanelle, De Voss, Christopher J., Tan, Lendl and West, Nicholas P. (2022). Two‐component sensor histidine kinases of Mycobacterium tuberculosis: beacons for niche navigation. Molecular Microbiology, 117 (5), 973-985. doi: 10.1111/mmi.14899

Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807

Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P. and Pellegrini, Marc (2021). Macrophage and neutrophil death programs differentially confer resistance to tuberculosis. Immunity, 54 (8), 1758-1771.e7. doi: 10.1016/j.immuni.2021.06.009

Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665

Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919

Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y

Barbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Baell, Jonathan B. and Priebbenow, Daniel L. (2021). Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit. RSC Medicinal Chemistry, 12 (6), 943-959. doi: 10.1039/d1md00063b

Awad, Milena M., Hutton, Melanie L., Quek, Adam J., Klare, William P., Mileto, Steven J., Mackin, Kate, Ly, Diane, Oorschot, Viola, Bosnjak, Marijana, Jenkin, Grant, Conroy, Paul J., West, Nick, Fulcher, Alex, Costin, Adam, Day, Christopher J., Jennings, Michael P., Medcalf, Robert L., Sanderson-Smith, Martina, Cordwell, Stuart J., Law, Ruby H.P., Whisstock, James C. and Lyras, Dena (2020). Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surface. Gastroenterology, 159 (4), 1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032

Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3

Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899

Lee, Brendon M., Harold, Liam K., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Nuermberger, Eric L., Cook, Gregory M. and Jackson, Colin J. (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathogens, 16 (2) e1008287, e1008287. doi: 10.1371/journal.ppat.1008287

Ang, Chee Wei, Tan, Lendl, Sykes, Melissa L., Abugharbiyeh, Neda, Debnath, Anjan, Reid, Janet C., West, Nicholas P., Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. Journal of Medicinal Chemistry, 63 (24), 15726-15751. doi: 10.1021/acs.jmedchem.0c01372

Serafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019). Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362

Pullella, Glenn A., Wdowiak, Adam P., Sykes, Melissa L., Lucantoni, Leonardo, Sukhoverkov, Kirill V., Zulfiqar, Bilal, Sobolev, Alexandre N., West, Nicholas P., Mylne, Joshua S., Avery, Vicky M. and Piggott, Matthew J. (2019). Total synthesis of the antimalarial ascidian natural product albopunctatone. Organic Letters, 21 (14), 5519-5523. doi: 10.1021/acs.orglett.9b01838

Jarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T. and Cooper, Matthew A. (2018). Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry, 61 (24) acs.jmedchem.8b01578, 11349-11371. doi: 10.1021/acs.jmedchem.8b01578

Eng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018). Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159, 10-22. doi: 10.1016/j.ejmech.2018.09.039

Sun, Hsien-Kuo, Pang, Angel, Farr, Dylan C., Mosaiab, Tamim, Britton, Warwick J., Anoopkumar-Dukie, Shailendra, Grice, I. Darren, Kiefel, Milton J., West, Nick P., Grant, Gary D. and Houston, Todd A. (2018). Thioamide derivative of the potent antitubercular 2-(decylsulfonyl) acetamide is less active against mycobacterium tuberculosis, but a more potent antistaphylococcal agent. Australian Journal of Chemistry, 71 (9), 716-719. doi: 10.1071/CH18206

Tan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018). Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 (6) e5146, e5146. doi: 10.7717/peerj.5146

Strong, Emily J. and West, Nicholas P. (2018). Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 (1) 5604, 5604. doi: 10.1038/s41598-018-23893-3

Ashhurst, Anneliese S, Parumasivam, Thaigarajan, Chan, John Gar Yan, Lin, Leon C W, Flórido, Manuela, West, Nicholas P, Chan, Hak-Kim and Britton, Warwick J (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PLoS One, 13 (3) e0194620, e0194620. doi: 10.1371/journal.pone.0194620

Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17

Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204

Ng, Benjamin Y. C., Wee, Eugene J. H., Woods, Kyra, Anderson, Will, Antaw, Fiach, Tsang, Hennes Z. H., West, Nicholas P. and Trau, Matt (2017). Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosis. Analytical Chemistry, 89 (17), 9017-9022. doi: 10.1021/acs.analchem.7b01685

Turner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17

Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017). Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 (1) 14414, 14414. doi: 10.1038/ncomms14414

Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16

Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985

Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985

Ng, Benjamin Y. C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding. ACS Sensors, 1 (2), 173-178. doi: 10.1021/acssensors.5b00171

Ng, Benjamin Y. C., Xiao, Wei, West, Nicholas P., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2015). Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Analytical Chemistry, 87 (20), 10613-10618. doi: 10.1021/acs.analchem.5b03121

Ng, Benjamin Y.C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis. Scientific Reports, 5 (1) 15027, 15027.1-15027.7. doi: 10.1038/srep15027

Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002

Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611

Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15

Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.

Marteyn, Benoit S., Karimova, Gouzel, Fenton, Andrew K., Gazi, Anastasia D., West, Nicholas, Touqui, Lhousseine, Prevost, Marie-Christine, Betton, Jean-Michel, Poyraz, Oemer, Ladant, Daniel, Gerdes, Kenn, Sansonetti, Philippe J. and Tang, Christoph M. (2014). ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. mBio, 5 (2) e00022-14. doi: 10.1128/mBio.00022-14

Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754

Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J. and Payne, R. J. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11 (46), 8113-8126. doi: 10.1039/c3ob41896k

Tyne, Anneliese S., Chan, John Gar Yan, Shanahan, Erin R., Atmosukarto, Ines, Chan, Hak-Kim, Britton, Warwick J. and West, Nicholas P. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31 (40), 4322-4329. doi: 10.1016/j.vaccine.2013.07.022

Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013). Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 (17), 6967-6984. doi: 10.1021/jm400779n

Pinto, Rachel, Leotta, Lisa, Shanahan, Erin R., West, Nicholas P., Leyh, Thomas S., Britton, Warwick and Triccas, James A. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. Journal of Infectious Diseases, 207 (5), 778-785. doi: 10.1093/infdis/jis751

Anh Thu Tran, West, Nicholas P., Britton, Warwick J. and Payne, Richard J. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. Chemmedchem, 7 (6), 1031-1043. doi: 10.1002/cmdc.201100606

Kao, Fan F., Mahmuda, Sultana, Pinto, Rachel, Triccas, James A., West, Nicholas P. and Britton, Warwick J. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7 (5) e34991, e34991. doi: 10.1371/journal.pone.0034991

Manos-Turvey, Alexandra, Cergol, Katie M., Salam, Noeris K., Bulloch, Esther M. M., Chi, Gamma, Pang, Angel, Britton, Warwick J., West, Nicholas P., Baker, Edward N., Lott, J. Shaun and Payne, Richard J. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10 (46), 9223-9236. doi: 10.1039/c2ob26736e

West, Nicholas P., Thomson, Scott A., Triccas, James A., Medveczky, C. Jill, Ramshaw, Ian A. and Britton, Warwick J. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29 (44), 7759-7765. doi: 10.1016/j.vaccine.2011.07.109

Anh Thu Tran, Cergol, Katie M., West, Nicholas P., Randall, Elizabeth J., Britton, Warwick J., Bokhari, Syed Ali Imran, Ibrahim, Musadiq, Lapthorn, Adrian J. and Payne, Richard J. (2011). Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads. Chemmedchem, 6 (2), 262-265. doi: 10.1002/cmdc.201000399

Triccas, James A., Winter, Nathalie, Feng, Carl G. and West, Nicholas P. (2011). Immunity to mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011 (406549) 406549, 1-2. doi: 10.1155/2011/406549

West, Nicholas P., Cergol, Katie M., Xue, Millie, Randall, Elizabeth J., Britton, Warwick J. and Payne, Richard J. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47 (18), 5166-5168. doi: 10.1039/c0cc05635a

Crellin, Paul K., Vivian, Julian P., Scoble, Judith, Chow, Frances M., West, Nicholas P., Brammananth, Rajini, Proellocks, Nicholas I., Shahine, Adam, Le Nours, Jerome, Wilce, Matthew C. J., Britton, Warwick J., Coppel, Ross L., Rossjohn, Jamie and Beddoe, Travis (2010). Tetrahydrolipstatin Inhibition, Functional Analyses, and Three-dimensional Structure of a Lipase Essential for Mycobacterial Viability. Journal of Biological Chemistry, 285 (39), 30050-30060. doi: 10.1074/jbc.M110.150094

Marteyn, Benoit, West, Nicholas P., Browning, Douglas F., Cole, Jeffery A., Shaw, Jonathan G., Palm, Fredrik, Mounier, Joelle, Prevost, Marie-Christine, Sansonetti, Philippe and Tang, Christoph M. (2010). Modulation of Shigella virulence in response to available oxygen in vivo. Nature, 465 (7296), 355-358+2. doi: 10.1038/nature08970

Shanahan, Erin R., Pinto, Rachel, Triccas, James A., Britton, Warwick J. and West, Nicholas P. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28 (5), 1341-1346. doi: 10.1016/j.vaccine.2009.11.010

West, Nicholas P., Chow, Frances M. E., Randall, Elizabeth J., Wu, Jing, Chen, Jian, Ribeiro, Jose M. C. and Britton, Warwick J. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. Faseb Journal, 23 (6), 1694-1704. doi: 10.1096/fj.08-114421

West, Nicholas P., Wozniak, Teresa M., Valenzuela, Jesus, Feng, Carl G., Sher, Alan, Ribeiro, Jose M. C. and Britton, Warwick J. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26 (31), 3853-3859. doi: 10.1016/j.vaccine.2008.05.007

Exley, RM, Shaw, J, Mowe, E, Sun, YH, West, NP, Williamson, M, Botto, M, Smith, H and Tang, CM (2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. Journal of Experimental Medicine, 201 (10), 1637-1645. doi: 10.1084/jem.20041548

West, NP, Sansonetti, P, Mounier, J, Exley, RM, Parsot, C, Guadagnini, S, Prevost, MC, Prochnicka-Chalufour, A, Delepierre, M, Tanguy, M and Tang, CM (2005). Optimization of virulence functions through glucosylation of Shigella LPS. Science, 307 (5713), 1313-1317. doi: 10.1126/science.1108472

West, NP, Sansonetti, PJ, Frankel, G and Tang, CM (2003). Finding your niche: what has been learnt from STM studies on GI colonization. Trends in Microbiology, 11 (7), 338-344. doi: 10.1016/S0966-842X(03)00154-9

McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9

West, N, Sansonetti, P and Tang, CM (2002). High throughput in vivo screens: Signature-tagged mutagenesis. Functional Microbial Genomics, 33, 153-165.

West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A. and Walker, Mark J. (2000). Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infection and Immunity, 68 (8), 4673-4680. doi: 10.1128/IAI.68.8.4673-4680.2000

Jungnitz, Heidrun, West, Nicholas P., Walker, Mark J., Chhatwal, Gursharan S. and Guzman, Carlos A. (1998). A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence. Infection and Immunity, 66 (10), 4640-4650.

West, NP, Fitter, JT, Jakubzik, U, Rodhe, M, Guzman, CA and Walker, MJ (1997). Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells. Fems Microbiology Letters, 146 (2), 263-269. doi: 10.1111/j.1574-6968.1997.tb10203.x

Conference Paper

Lee, Brendon, Almeida, Deepak, Afriat-Jurnou, Livnat, Aung, Htin, Forde, Brian, Harold, Liam, Hards, Kiel, Pidot, Sacha, Ahmed, Hafna, Mohamed, Elaaf, Taylor, Mathew, West, Nicholas, Stinear, Timothy, Greening, Chris, Beatson, Scott, Cook, Gregory, Nuermberger, Eric and Jackson, Colin (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. Annual Meeting on Experimental Biology, San Diego, CA, United States, 4-7 April 2020. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1096/fasebj.2020.34.s1.04923