Australian Infectious Diseases Research Centre

Professor Kate Stacey

Professor
School of Chemistry and Molecular Biosciences
+61 7 336 54640
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Primary research interest

Cellular response to foreign nucleic acids

About me

Research and teaching in immunology

Following my PhD on transcriptional regulation in macrophages I went in 1996 to the University of Cambridge on a CJ Martin Fellowship to work in a molecular parasitology laboratory. I returned to the Institute for Molecular Bioscience at The University of Queensland in 1998 where I continued work on immune cell responses to foreign DNA. I was awarded an Australian Research Council Future Fellowship in 2009 to move to the School of Chemistry & Molecular Biosciences.

Research focus and collaborations

Pathogen recognition by the innate immune system

The broad theme of my laboratory is innate immune cell recognition of pathogens. The last decade has seen an explosion of information on how cells identify the presence of invading organisms. This principally involves cells of the innate immune system which identify an infection and subsequently activate the acquired immune system (T and B cells). “Pattern recognition receptors” (PRR) on innate immune cells bind to characteristically foreign molecules which are conserved amongst groups of pathogens. These foreign molecules are called “PAMPs” or “Pathogen associated molecular patterns”. The bacterial cell wall provides many PAMPs for recognition of bacterial infection, such as lipopolysaccharide, peptidoglycan, lipoproteins and flagellin. Detection of viral infection is more challenging, as viruses have very diverse molecules and can evolve rapidly to evade detection. However all viruses carry nucleic acids, and these are emerging as key to the initiation of anti-viral responses. The particular focus of my laboratory is cellular recognition of foreign nucleic acids. These responses are relevant not only to infectious disease, but also to the autoimmune disease lupus, other inflammatory conditions and possibly cancer. A knowledge of cellular responses to introduced DNA will also aid improvements in techniques which rely on the introduction of DNA into cells, such as experimental transfection and gene therapy.

Recognition of foreign extracellular/endosomal DNA

Responses of cells to foreign DNA fall into two categories. Firstly, Toll-like receptor 9 (TLR9) recognises DNA within the endosomal compartment. This DNA can arise from the uptake of free DNA by cell surface receptors, or by uptake of organisms which are broken down in the phagosomal/endosomal system, releasing DNA. TLR9 responses are elicited by DNA which is deficient in methylation of the cytosine residue in CG dinucleotides. Vertebrate DNA is not stimulatory, due to a low frequency of unmethylated CG sequences. These bacterial and viral “CpG” motifs trigger cellular signalling leading to secretion of inflammatory cytokines and enhancement of antigen presenting cell function. TLR9 responses are seen in murine B cells and macrophages, and will stimulate immune defence, without implying that the responding cell is infected, since DNA was only recognised within the endosomal compartment.

Recognition of cytosolic DNA

Several other systems of DNA recognition operate in the cytoplasm of infected cells, and are likely to be critical in recognition of infection of cells with DNA viruses and retroviruses. Cells respond to cytosolic DNA with secretion of interferon-beta, a powerful anti-viral molecule, as well as cell death and secretion of the inflammatory cytokine interleukin-1beta (IL-1beta). Both cell death and IL-1beta are dependent on recognition of foreign DNA by the PYHIN (HIN-200) protein AIM2, which initiates formation of the “inflammasome” – a protein complex which recruits and activates the protease caspase 1. Caspase 1 cleaves pro-IL-1beta prior to its secretion, and also initiates “pyroptosis”- rapid lytic cell death which promotes inflammation. We recently discovered that the inflammasome initiates a second pathway of cell death (apoptotic death) in parallel, via activation of caspase 8. We showed that the function of AIM2 is inhibited by another DNA-binding PYHIN family member p202. p202 is variably expressed between mouse strains and may be involved in susceptibility to viral or bacterial infection. Work in our lab continues to investigate the role of PYHIN proteins in responses to foreign DNA, as well as the evolution of defences against DNA. We are particularly interested in mechanisms of cell death mediated by recognition of foreign DNA, and the relevance of these pathways to autoimmunity.

Projects

  • Initiation of cell death pathways by recognition of cytosolic DNA
  • Evolution of defences against invading DNA
  • Structure and functional analysis of PYHIN (HIN-200) proteins
  • Responses to DNA in the autoimmune disease systemic lupus erythematosus
  • Protein-protein interactions involved in inflammasome-induced apoptotic death
  • Endogenous retroelements in cancer

Collaborations

  • Prof Hao Wu, Harvard Medical School. Structure and function of PYHIN proteins
  • Assoc Prof Richard Ferrero, Monash University. Innate immune stimulation by bacterial outer membrane vesicles
  • Dr Matt Sweet, University of Queensland. Anti-microbial effects of zinc
  • Assoc Prof Mariapia Degli-Esposti, Lions Eye Institute WA. Inflammasome-mediated responses to MCMV
  • Dr Michelle Wykes, QIMR. Inflammasome responses in malarial infection
  • Dr Kate Schroder, University of Queensland. Protein-protein interactions in the inflammasome

Funded projects

  • NHMRC Research Fellowship (SRFA) 2014-2018, Inflammasome function in protection against infectious disease and autoimmunity
  • NHMRC Project Grant 2014-2016, PR Young, KJ Stacey & JM Mackenzie, The dengue virus glycoprotein NS1 binds cholesterol and mediates cellular activation, Total value of grant: $611,226
  • NHMRC Project Grant 2013-2015, KJ Stacey & K Schroder, Caspase 8 apoptotic signalling induced by the inflammasome, Total value of grant: $582,000
  • NHMRC Project Grant 2011-2013, KJ Stacey & TL Roberts, The mechanism of death in response to cytoplasmic DNA, and its role in tumour suppression, Total value of grant: $500,000
  • NHMRC Project Grant 2010-2012 KJ Stacey, TL Roberts & MJ Sweet, Cytoplasmic DNA as a danger signal for mammalian cells, Total value of grant: $571,000
  • ARC Discovery Grant 2012-2014, KJ Stacey, Combatting DNA: A process conserved in evolution?, Total value of grant: $295,000
  • ARC Discovery Grant 2012-2014, RL Ferrero (Monash University) & KJ Stacey, Caspase 8 apoptotic signalling induced by the inflammasome, Total value of grant: $270,000
  • ARC Future Fellowship 2009-2013, Foreign DNA is a danger signal for mammalian cells, Total value of grant: $686,400

Teaching interests

Achievements and awards

  • 2011 Immunology and Cell Biology Chris and Bhama Parish Publication of the Year Award (TL Roberts, first author)
  • 2010 NHMRC Career Development Award Level 2 (not taken up)
  • 2009 ARC Future Fellowship
  • 2004 University of Queensland Fellowship for Women (part-time)
  • 1996 CJ Martin Fellowship

Featured publications

Publications by Kate Stacey

Researcher biography

My work focusses on activation of innate immune cells by pathogen products. Following my PhD at UQ on transcriptional regulation in macrophages I went in 1996 to the University of Cambridge on a CJ Martin Fellowship to work in a molecular parasitology laboratory. I returned to the the University of Queensland in where I focussed on immune cell responses to foreign DNA. I was awarded an ARC Future Fellowship in 2009 to move to the School of Chemistry and Molecular Bioscience, where I also lecture in immunology.

Publications

Book Chapters (7)
Journal Articles (84)
Conference Papers (19)

Book Chapters

Watterson, Daniel, Modhiran, Naphak, Muller, David A., Stacey, Katryn J. and Young, Paul R. (2018). Plugging the leak in Dengue shock. Dengue and Zika: Control and Antiviral Treatment Strategies. (pp. 89-106) edited by Rolf Hilgenfeld and Subhash G. Vasudevan. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-8727-1_7
Sester, David P., Zamoshnikova, Alina, Thygesen, Sara J., Vajjhala, Parimala R., Cridland, Simon O., Schroder, Kate and Stacey, Katryn J. (2016). Assessment of inflammasome formation by flow cytometry. Current protocols in immunology. (pp. 14.40.1-14.40.29) edited by Coligan, John E., Bierer, Barbara, Margulies, David H., Shevach, Ethan M. and Strober, Warren. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/cpim.13
Stacey, Katryn J., Idris, Adi, Sagulenko, Vitaliya, Vitak, Nazarii and Sester, David P. (2016). Methods for delivering DNA to intracellular receptors. Toll-like receptor detection and activation. (pp. 93-106) edited by Claire E. McCoy. New York, NY, United States: Springer Science+Business Media. doi: 10.1007/978-1-4939-3335-8_6
Stacey, Katryn J., Clark, Francis, Young, Greg R. and Roberts, Tara L. (2008). Discrimination of self and non-self DNAs. Nucleic Acids in Innate Immunity. (pp. 85-100) edited by Ken J. Ishii and Shizuo Akira. Boca Raton, FL, USA: CRC Press.
Stacey, K. J., Sester, D. P., Naik, S., Roberts, T., Sweet, M. J. and Hume, D. A. (2002). Phosphorothioate backbone modification changes the pattern of responses to CpG. Microbial DNA and host immunity. (pp. 63-77) Totowa, New Jersey: Humana Press. doi: 10.1007/978-1-59259-305-7_6
Hume, D. A., Stacey, K. J., Cassady, A. ., Browne, C. M., Sweet, M. J. and Bertoncello, I. (1996). Growth and differentiation of murine macrophages. Handbook of experimental immunology. (pp. 160.1-160.10) Boston: Wiley-Blackwell.
Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. Mononuclear Phagocytes: Biology of Monocytes and Macrophages. (pp. 233-240) edited by van Furth, R.. Dordrecht , Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8070-0

Journal Articles

Li, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210
Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055
Thygesen, Sara J, Burgener, Sabrina S, Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515
Pliego Zamora, Adriana, Kim, Jaehyeon, Vajjhala, Parimala R., Thygesen, Sara J., Watterson, Daniel, Modhiran, Naphak, Bielefeldt-Ohmann, Helle and Stacey, Katryn J. (2023). Kinetics of severe dengue virus infection and development of gut pathology in mice. Journal of Virology, 97 (11) ARTN e0125123, e0125123. doi: 10.1128/jvi.01251-23
Curson, James E. B., Liu, Liping, Luo, Lin, Muusse, Timothy W., Lucas, Richard M., Gunther, Kimberley S., Vajjhala, Parimala R., Abrol, Rishika, Jones, Alun, Kapetanovic, Ronan, Stacey, Katryn J., Stow, Jennifer L. and Sweet, Matthew J. (2023). TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology, 53 (7) e2250056, e2250056. doi: 10.1002/eji.202250056
Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0
Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666
Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6
Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A., Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T. M., Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A. P., Freney, Morgan E., Newton, Natalee D., Khromykh, Alexander A., Chappell, Keith J., Muller, David A., Stacey, Katryn J., Landsberg, Michael J., Shi, Yi, Gao, George F., Young, Paul R. and Watterson, Daniel (2021). A broadly protective antibody that targets the flavivirus NS1 protein. Science, 371 (6525), 190-194. doi: 10.1126/science.abb9425
Thygesen, Sara J., Pliego‐Zamora, Adriana and Stacey, Katryn J. (2020). Manipulation of epithelial cell death pathways by Shigella. The EMBO Journal, 39 (17), e106202. doi: 10.15252/embj.2020106202
Thygesen, Sara J. and Stacey, Katryn J. (2019). IRF 1 and IRF 2 regulate the non‐canonical inflammasome. EMBO reports, 20 (9) e48891, e48891. doi: 10.15252/embr.201948891
Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004
Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193
Bitto, Natalie J., Baker, Paul J., Dowling, Jennifer K., Wray-McCann, Georgie, De Paoli, Amanda, Tran, Le Son, Leung, Pak Ling, Stacey, Katryn J., Mansell, Ashley, Masters, Seth L. and Ferrero, Richard L. (2018). Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes. Immunology and Cell Biology, 96 (10), 1120-1130. doi: 10.1111/imcb.12190
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E and Stacey, Katryn J (2017). Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8. Journal of Molecular Biology, 430 (2), 238-247. doi: 10.1016/j.jmb.2017.10.028
Bitto, Natalie J., Chapman, Ross, Pidot, Sacha, Costin, Adam, Lo, Camden, Choi, Jasmine, D'Cruze, Tanya, Reynolds, Eric C., Dashper, Stuart G., Turnbull, Lynne, Whitchurch, Cynthia B., Stinear, Timothy P., Stacey, Katryn J. and Ferrero, Richard L. (2017). Bacterial membrane vesicles transport their DNA cargo into host cells. Scientific Reports, 7 (1) 7072, 7072. doi: 10.1038/s41598-017-07288-4
Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444
Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012
Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017). Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 (5), 491-495. doi: 10.1038/icb.2017.5
Fu, Tian-Min, Li, Yang, Lu, Alvin, Li, Zongli, Vajjhala, Parimala R., Cruz, Anthony C., Srivastava, Devendra B., DiMaio, Frank, Penczek, Pawel A., Siegel, Richard M., Stacey, Katryn J., Egelman, Edward H. and Wu, Hao (2016). Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex. Molecular Cell, 64 (2), 236-250. doi: 10.1016/j.molcel.2016.09.009
Karunarathne, Deshapriya S., Horne-Debets, Joshua M., Huang, Johnny X., Faleiro, Rebecca, Leow, Chiuan Yee, Amante, Fiona, Watkins, Thomas S., Miles, John J., Dwyer, Patrick J., Stacey, Katryn J., Yarski, Michael, Poh, Chek Meng, Lee, Jason S., Cooper, Matthew A., Rénia, Laurent, Richard, Derek, McCarthy, James S., Sharpe, Arlene H. and Wykes, Michelle N. (2016). Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4+ T cell immunity. Immunity, 45 (2), 333-345. doi: 10.1016/j.immuni.2016.07.017
Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023
Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061
Thygesen, Sara J., Sester, David P., Cridland, Simon O., Wilton, Steve D. and Stacey, Katryn J. (2016). Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides. Immunology and Cell Biology, 94 (5), 520-524. doi: 10.1038/icb.2016.3
Schaale, K., Peters, K. M., Murthy, A. M., Fritzsche, A. K., Phan, M.-D., Totsika, M., Robertson, A. A. B., Nichols, K. B., Cooper, M. A., Stacey, K. J., Ulett, G. C., Schroder, K., Schembri, M. A. and Sweet, M. J. (2016). Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.. Mucosal Immunology, 9 (1), 124-136. doi: 10.1038/mi.2015.44
Stacey, Katryn J., Watterson, Daniel, Modhiran, Naphak and Young, Paul R. (2015). Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination". Science Translational Medicine, 7 (318) 318lr4, 318lr4-318lr4. doi: 10.1126/scitranslmed.aad8657
Vajjhala, Parimala R., Lu, Alvin, Brown, Darren L., Pang, Siew Wai, Sagulenko, Vitaliya, Sester, David P., Cridland, Simon O., Hill, Justine M., Schroder, Kate, Stow, Jennifer L., Wu, Hao and Stacey, Katryn J. (2015). The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry, 290 (49), 29217-29230. doi: 10.1074/jbc.M115.687731
Sester, David P. and Stacey, Katryn J. (2015). Response to Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice".. Journal of Immunology, 195 (10), 4552-4553. doi: 10.4049/jimmunol.1501930
Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 (304) 304ra142, 1-10. doi: 10.1126/scitranslmed.aaa3863
Sester, David P., Sagulenko, Vitaliya, Thygesen, Sara J., Cridland, Jasmyn A., Loi, Yen Siew, Cridland, Simon O., Masters, Seth L., Genske, Ulrich, Hornung, Veit, Andoniou, Christopher E., Sweet, Matthew J., Degli-Esposti, Mariapia A., Schroder, Kate and Stacey, Katryn J. (2015). Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.. Journal of Immunology, 195 (3), 1233-1241. doi: 10.4049/jimmunol.1402859
Vitak, Nazarii, Johnson, Karyn N., Sester, David P. and Stacey, Katryn J. (2015). A novel pathway of cell death in response to cytosolic DNA in Drosophila cells. Journal of Innate Immunity, 7 (2), 212-222. doi: 10.1159/000368276
Sester, David P., Thygesen, Sara J., Sagulenko, Vitaliya, Vajjhala, Parimala R., Cridland, Jasmyn A., Vitak, Nazarii, Chen, Kaiwen W., Osborne, Geoffrey W., Schroder, Kate and Katryn J. Stacey (2015). A novel flow cytometric method to assess inflammasome formation. The Journal of Immunology, 194 (1), 455-462. doi: 10.4049/jimmunol.1401110
Chen, Kaiwen W., Groß, Christina J., Vasquez Sotomayor, Flor, Stacey, Katryn J., Tschopp, Jurg, Sweet, Matthew J. and Schroder, Kate (2014). The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge. Cell Reports, 8 (2), 570-582. doi: 10.1016/j.celrep.2014.06.028
Vajjhala, Parimala R., Kaiser, Sebastian, Smith, Sarah J., Ong, Qi-Rui, Soh, Stephanie L., Stacey, Katryn J. and Hill, Justine M. (2014). Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly. Journal of Biological Chemistry, 289 (34), 23504-23519. doi: 10.1074/jbc.M114.553305
Allam, Ramanjaneyulu, Lawlor, Kate E., Yu, Eric Chi-Wang, Mildenhall, Alison L., Moujalled, Donia M., Lewis, Rowena S., Ke, Francine, Mason, Kylie D., White, Michael J., Stacey, Katryn J., Strasser, Andreas, O'Reilly, Lorraine A., Alexander, Warren, Kile, Benjamin T., Vaux, David L. and Vince, James E. (2014). Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO reports, 15 (9), 982-990. doi: 10.15252/embr.201438463
Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T., Schroder, K., Vince, J. E., Hill, J. M., Silke, J. and Stacey, K. J. (2013). AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation, 20 (9), 1149-1160. doi: 10.1038/cdd.2013.37
Yin, Qian, Sester, David P., Tian, Yuan, Hsiao, Yu-Shan, Lu, Alvin, Cridland, Jasmyn A., Sagulenko, Vitaliya, Thygesen, Sara J., Choubey, Divaker, Hornung, Veit, Walz, Thomas, Stacey, Katryn J. and Wu, Hao (2013). Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation. Cell Reports, 4 (2), 327-339. doi: 10.1016/j.celrep.2013.06.024
Aachoui, Youssef, Sagulenko, Vitaliya, Miao, Edward A. and Stacey, Katryn J. (2013). Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Current Opinion in Microbiology, 16 (3), 319-326. doi: 10.1016/j.mib.2013.04.004
Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020
Liu, Xue Q., Stacey, Katryn J., Horne-Debets, Joshua M., Cridland, Jasmyn A., Fischer, Katja, Narum, David, Mackay, Fabienne, Pierce, Susan K. and Wykes, Michelle N. (2012). Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. European Journal of Immunology, 42 (12), 3291-3301. doi: 10.1002/eji.201242689
Lahoud, Mireille H., Ahmet, Fatma, Zhang, Jian-Guo, Meuterb, Simone, Policheni, Antonia N., Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C., Brooks, Andrew G., Berry, Richard, Rossjohn, Jamie, Mintern, Justine D., Vega-Ramos, Javier, Villadangos, Jose A., Nicola, Nicos A., Nussenzweig, Michel C., Stacey, Katryn J., Shortman, Ken, Heath, William R. and Caminschi, Irina (2012). DEC-205 is a cell surface receptor for CpG oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109 (40), 16270-16275. doi: 10.1073/pnas.1208796109
Cridland, Jasmyn A., Curley, Eva Z., Wykes, Michelle N ., Schroder, Kate, Sweet, Matthew J., Roberts, Tara L., Ragan, Mark A., Kassahn, Karin S. and Stacey, Katryn J. (2012). The mammalian PYHIN gene family: Phylogeny, evolution and expression. BMC Evolutionary Biology, 12 (1) 140, 140.1-140.33. doi: 10.1186/1471-2148-12-140
Bokil, Nilesh J., Totsika, Makrina, Carey, Alison J., Stacey, Katryn J., Hancock, Viktoria, Saunders, Bernadette M., Ravasi, Timothy, Ulett, Glenn C., Schembri, Mark A. and Sweet, Matthew J. (2011). Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages. Immunobiology, 216 (11), 1164-1171. doi: 10.1016/j.imbio.2011.05.011
Roberts, Tara L., Turner, Marian L., Dunn, Jasmyn A., Lenert, Petar, Ross, Ian L., Sweet, Matthew J. and Stacey, Katryn J. (2011). B cells do not take up bacterial DNA: An essential role for antigen in exposure of DNA to toll-like receptor-9. Immunology and Cell Biology, 89 (4), 517-525. doi: 10.1038/icb.2010.112
Roberts, Tara L., Dunn, Jasmyn A., Sweet, Matthew J., Hume, David A. and Stacey, Katryn J. (2011). The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. Molecular Immunology, 48 (8), 1027-1034. doi: 10.1016/j.molimm.2011.01.011
Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723
Stacey, Katryn J. and Sagulenko, Vitaliya (2010). A clear link between endogenous retroviral LTR activity and Hodgkin's lymphoma. Cell Research, 20 (8), 869-871. doi: 10.1038/cr.2010.96
Maetschke, Stefan R., Kassahn, Karin S., Dunn, Jasmyn A., Han, Siew-Ping, Curley, Eva Z., Stacey, Katryn J. and Ragan, Mark A. (2010). A visual framework for sequence analysis using n-grams and spectral rearrangement. Bioinformatics, 26 (6) btq042, 737-744. doi: 10.1093/bioinformatics/btq042
Trieu, Angela, Bokil, Nilesh, Dunn, Jasmyn A., Roberts, Tara L., Xu, Damo, Liew, Foo Y., Hume, David A., Stacey, Katryn J. and Sweet, Matthew J. (2009). TLR-9-independent effects of inhibitory oligonucleotides on macrophages responses to S. typhimurium. Immunology and Cell Biology, 87 (3), 218-225. doi: 10.1038/icb.2008.95
Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009). HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 (5917), 1057-1060. doi: 10.1126/science.1169841
Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 (6), 3495-3503. doi: 10.4049/jimmunol.179.6.3495
Wykes, Michelle N., Liu, Xue Q., Beattie, Lynette, Stanisic, Danielle I., Stacey, Katryn J., Smyth, Mark J., Thomas, Ranjeny and Good, Michael F. (2007). Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathogens, 3 (7), e96-0904-e96-0912. doi: 10.1371/journal.ppat.0030096
Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007). PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 (6), 1577-1590. doi: 10.1189/jlb.0107036
Sester, D. P., Brion, K., Trieu, A., Goodridge, H. S., Roberts, T. L., Dunn, J., Hume, D. A., Stacey, K. J. and Sweet, M. J. (2006). CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. Journal of Immunology, 177 (7), 4473-4480. doi: 10.4049/jimmunol.177.7.4473
Trieu, A., Roberts, T. L., Dunn, J. A., Sweet, M. J. and Stacey, K. J. (2006). DNA Motifs Suppressing TLR9 Responses. Critical reviews in Immunology, 26 (6), 527-544. doi: 10.1615/CritRevImmunol.v26.i6.50
Brummel, Rachel, Roberts, Tara L., Stacey, Katryn J. and Lenert, Petar (2006). Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. European Journal of Immunology, 36 (7), 1951-1962. doi: 10.1002/eji.200535734
Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005). Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 (2), 605-608. doi: 10.4049/jimmunol.174.2.605
Srikhanta, Y. N., Maguire, T. L., Stacey, K. J., Grimmond, S. M. and Jennings, M. P. (2005). The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes. Proceedings of The National Academy of Sciences of The United States of America, 102 (15), 5547-5551. doi: 10.1073/pnas.0501169102
Sester, D. P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J. A., McDonald, R. C., Ripoll, V., Wells, C. A., Suzuki, H., Hayashizaki, Y., Stacey, K. J., Hume, D. A. and Sweet, M. J. (2005). LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology, 210 (2-4), 97-107. doi: 10.1016/j.imbio.2005.05.004
Andoniou, C. E., van Dommelen, S. L. H., Voigt, V., Andrews, D. M., Brizard, G., Asselin-Paturel, C., Delale, T., Stacey, K. J., Trinchieri, G. and Degli-Esposti, M. A. (2005). Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nature Immunology, 6 (10), 1011-1019. doi: 10.1038/ni1244
Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005). Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 (6), 3569-3576. doi: 10.4049/jimmunol.175.6.3569
Stacey, Katryn J., Young, Greg R., Clark, Francis, Sester, David P., Roberts, Tara L., Naik, Shalin, Sweet, Matthew J. and Hume, David A. (2003). The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. Journal of Immunology, 170 (7), 3614-3620. doi: 10.4049/jimmunol.170.7.3614
Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., Hume, David A. and Liew, Foo Y. (2002). Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. Journal of Immunology, 168 (1), 392-399. doi: 10.4049/jimmunol.168.1.392
Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000). G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 (7), 3870-3877. doi: 10.4049/jimmunol.164.7.3870
Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000). Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247, 41-58. doi: 10.1007/978-3-642-59672-8_3
Fowles, L. F., Stacey, K. J., Marks, D., Hamilton, J. A. and Hume, D. A. (2000). Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochemical Journal, 347 (1), 313-320. doi: 10.1042/0264-6021:3470313
Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000). Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 (8), 4165-4173. doi: 10.4049/jimmunol.165.8.4165
Stacey, Katryn J. and Blackwell, Jenefer M. (1999). Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infection and Immunity, 67 (8), 3719-3726. doi: 10.1128/iai.67.8.3719-3726.1999
Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999). Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 (1), 172-183. doi: 10.1002/jlb.66.1.172
Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999). Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 (3), 528-534. doi: 10.1002/jlb.66.3.528
Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999). Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 (12), 6541-6550.
Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999). The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 (4), 542-548. doi: 10.1002/jlb.66.4.542
Fowles, Lindsay F., Martin, Michele L., Nelsen, Lori, Stacey, Katryn J., Redd, Douglas, Clark, Ying Mei, Nagamine, Yoshikune, McMahon, Martin, Hume, David A. and Ostrowski, Michael C. (1998). Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating Factor 1/c-fms Signaling. Molecular and Cellular Biology, 18 (9), 5148-5156. doi: 10.1128/MCB.18.9.5148
Sweet, M. J., Stacey, K. J., Kakuda, D. K., Markovich, D. and Hume, D. A. (1998). IFN-γ primes macrophage responses to bacterial DNA. Journal of Interferon and Cytokine Research, 18 (4), 263-271. doi: 10.1089/jir.1998.18.263
Sweet, M. J., Stacey, K. J., Ross, I. L., Ostrowski, M. C. and Hume, D. A. (1998). Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophage. Journal of Inflammation, 48 (2), 67-83.
Yang, Beom-Seok, Hauser, Craig A., Henkel, Gregory, Colman, Michael S., Van Beveren, Charles, Stacey, Katryn J., Hume, David A., Maki, Richard A. and Ostrowski, Michael C. (1996). Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Molecular and Cellular Biology, 16 (2), 538-547. doi: 10.1128/MCB.16.2.538
Stacey, K. J., Sweet, M. J. and Hume, D. A. (1996). Macrophages ingest and are activated by bacterial DNA. Journal of Immunology, 157 (5), 2116-2122.
Stacey, Katryn J., Fowles, Lindsay F., Colman, Michael S., Ostrowski, Michael C. and Hume, David A. (1995). Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Molecular and Cellular Biology, 15 (6), 3430-3441. doi: 10.1128/MCB.15.6.3430
Stacey, Katryn J., Nagamine, Yoshikuni and Hume, David A. (1994). RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letters, 356 (2-3), 311-313. doi: 10.1016/0014-5793(94)01294-6
Stacey, Katryn J., Ross, Ian L. and Hume, David A. (1993). Electroporation and DNA-dependent cell-death in murine macrophages. Immunology and Cell Biology, 71 (2), 75-85. doi: 10.1038/icb.1993.8
Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993). The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 (3), 392-401. doi: 10.1111/j.1365-2141.1993.tb03092.x
Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991). Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 (24), 6839-6847. doi: 10.1093/nar/19.24.6839
Stacey, Kate, Beasley, Barbara, Wilce, Peter A. and Martin, Len (1991). Effects of female sex hormones on lipid metabolism in the uterine epithelium of the mouse. International Journal of Biochemistry, 23 (3), 371-376. doi: 10.1016/0020-711X(91)90121-3

Conference Papers

Kobe, Bostjan, Nanson, Jeffrey D., Manik, Mohammad K., Li, Sulin, Gu, Weixi, Pan, Mengqi, Li, Yan, Muusse, Timothy W., Vajjhala, Parimala R, Stacey, Katryn J., Holmes, Susannah, Darmanin, Connie, Clabbers, Max T. B., Xu, Hongyi, Shi, Yun and Ve, Thomas (2023). Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093658
Nanson, J. D., Muusse, T. W., Li, Y., Pan, M., Landsberg, M. J., Vajjhala, P. R., Ve, T., Stacey, K. J. and Kobe, B. (2023). TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086631
Thygesen, Sara Judith, Sester, David P. and Stacey, Katryn J. (2017). NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa, Japan, 29 October - 2 November 2017. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2017.09.010
Vitak, N., Johnson, K. N., Hume, D. A., Sester, D. P. and Stacey, K. J. (2016). Evolution of cell death responses to cytosolic DNA. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Chen, K., Gross, C., Wall, A., Stacey, K., Stow, J., Sweet, M. and Schroder, K. (2016). Inflammatory response sculpting by neutrophil inflammasomes. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Thygesen, S. J., Sester, D. P., Sagulenko, V. and Stacey, K. J. (2016). Inflammasome function in autoimmunity. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley-Blackwell.
Vajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Stacey, K. J., Vajjhala, P. R., Sagulenko, V, Thygesen, S., Vitak, N. and Sester, D. P. (2016). Cytosolic DNA, HIN-200 proteins and inflammasome activation. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Sweet, M. J., Schroder, K., Irvine, K. M., Taylor, M., Bokil, N. J., Broomfield, S., Schembri, M. A., Stacey, K. J. and Hume, D. A. (2012). Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse. European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Oxford, United Kingdom: Wiley-Blackwell. doi: 10.1111/imm.12002
Stacey, K. J., Roberts, T. L., Idris, A., Dunn, A., Hume, D. A. and Ross, I. L. (2005). A detection system for viral dsDNA?. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, 29 November - 2 December 2005. Copenhagan, Denmark: John Wiley & Sons. doi: 10.1111/j.1399-0039.2005.00523.x
Idris, A., Ross, I. L. and Stacey, K. J. (2005). Cellular activation and apoptosis in response to transfected dsDNA - A novel foreign nucleic acid detection system. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, 29 November - 2 December 2005. Copenhagan, Denmark: John Wiley & Sons. doi: 10.1111/j.1399-0039.2005.00523.x
Sweet, Matthew J., Schroder, Kate, Sester, David P., Trieu, Angela, Rehli, Michael, Risvanathan, Kumar, Stacey, Katryn J. and Hume, David A. (2005). Regulation and function of toll-like receptor 9 in macrophages. 7th World Congress on Inflammation, Melbourne, VIC Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Roberts, Tara L., Dann, Jasmyn A., Sweet, Matthew J., Hume, David A., Lenert, Petar and Stacey, Katryn J. (2005). Purified splenic B-cells do not respond to E. coli DNA. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Trieu, Angela, Cronau, Steve, Roberts, Tara, Lottin, Jane, Vlahos, Ross, Stacey, Katryn J., Hume, David A. and Sweet, Matthew J. (2005). Blockade of CSF-1 action enhances CpG DNA responses in vivo. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
Stacey, K. J., Sester, D. P., Murphy, K. M., Sweet, M. J. and Hume, D. A. (2000). Replication protein A binds preferentially to immunostimulatory oligonucleotides.. -, -, -. Bethesda, MD United States: Federation of American Societies for Experimental Biology.
Sester, D. P., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). Immunostimulatory DNA promotes factor independent survival of macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Australian Society for Biochemistry & Molecular Biology.
Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, 22-26 September, 1999. Bethesda, Maryland: Society for Leukocyte Biology.
Stacey, K. J., Sweet, M. and Hume, D. A. (1996). Activation of macrophages by bacterial DNA. -, -, -. Oxford, United Kingdom: John Wiley & Sons .
Stacey, K. J., Fowles, L. F., Coleman, M. S., Ostrowski, M. and Hume, D. A. (1993). Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester. -, -, -. United Kingdom: John Wiley & Sons.