Professor Luke Guddat

Professor

School of Chemistry and Molecular Biosciences

+61 7 336 53549

luke.guddat@uq.edu.au

View researcher profile

Primary research interest

Protein structure and drug discovery

Additional roles

Research scientist and laboratory head School of Chemistry & Molecular Biosciences
Lecturer and course coordinator in biochemistry
Postgraduate coordinator in biochemistry

About me

PhD obtained from St Vincents Institute of Medical Research, Melbourne, Australia (1990)
Postdoctoral research University of Utah, and Harrington Cancer Center, USA (1991-1994)
Staff member The University of Queensland (1995-present)
Associate Professor, The University of Queensland (2010-present)

Research focus and collaborations

My fields of research are structural biology and rational drug design. The group uses X-ray crystallography and other physical measurements to determine how structure influences the function of enzymes. This knowledge allows us to rationally design and develop enzyme inhibitors that can act as therapeutic agents or herbicides.

Four enzyme classes are being studied:

those involved in nucleotide biosynthesis;
enzymes in the branched-chain amino acid biosynthesis pathway;
metalloenzymes
serine proteases in the blood clotting cascade.

Hypoxanthine-guanine phosphoribosyltransferase takes the naturally 6-oxopurines, hypoxanthine or guanine and phosphoribosylpyrophosphate and converts these to the nucleotides required for DNA/RNA synthesis. We are now targeting the Plasmodium falciparum and Plasmodium vivax enzymes to discover new inhibitors that we design to test as anti-malarial drugs.

We determined the three-dimesional structures of the catalytic subunit of plant, bacterial and fungal acetohydroxyacid acid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. In plants, this enzyme is the target for a number of commercial herbicides including members of the sulfonylurea and imidazolinone families.

Two goals are:

to use this data to discover new AHAS inhibitors as biocide leads
to determine the structure of the regulatory subunit of AHAS.

We have determined the structures of plant, and bacterial ketol-acid reductoisomerase (KARI), the second enzyme in the branched-chain amino acid biosynthetic pathway. The enzyme contains two closely spaced metals and NADPH and undergoes major structural changes during its catalytic cycle. We are currently investigating these structures. KARI’s position in the branched-chain biosynthesis pathway also makes it an attractive target to discover new biocides.

We have determined the structures of plant and animal purple acid phosphatase, a metalloenzyme with two closely spaced metal centres. Based on our latest structures we have proposed a detail mechanism of catalysis for this enzyme. Inhibitors of the animal enzyme are considered excellent anti-osteoporotic drug leads.

We are studying the structure and inhibition of the serine proteases, plasmin and plasma kallikrein, and their roles in the blood clotting cascade. Our group is discovering protease inhibitors within Australian snake venoms as potential therapeutic drug leads.

Funded projects

An integrated approach to combat antibiotic resistance - NHMRC project - Guddat, Schenk, McGeary, Sidjabat 2015-2017
An integrated approach to antimalarial drug discovery-NHMRC-project- Guddat, Hockova, Edstein, Naesens, de Jersey 2012-2014
Acetohydroxyacid synthase: A target for antifungal therapy NHMRC-project Guddat, Wang, Fraser 2011-2013

Teaching interests

BIOL1007 Molecular & Cellular Biology
BIOL1040 Cells to Organisms
BIOC3000 Advanced Biochemistry and Molecular Biology
BINF6001 Introduction to Proteins & Nucleic Acids
BIOC6007 Directed Studies in Biomolecular Structure & Function
BIOC7004 Advanced Protein Technology

Featured publications

McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014) The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76 132-144. doi:10.1016/j.ejmech.2014.02.008
Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013) Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 4: 615-629. doi:10.1124/mol.113.087247

Publications by Luke Guddat

Publications

Book Chapters (3)

Journal Articles (220)

Conference Papers (23)

Data Collection (1)

Book Chapters

Lavin, Martin F., Earl, Stephen, Birrell, Geoff, St. Pierre, Liam, Guddat, Luke W., John de Jersey and Masci, Paul (2009). Snake venom nerve growth factors. Handbook of Venoms and Toxins of Reptiles. (pp. 377-392) edited by Stephen P Mackessy. United States of America: CRC Press, Taylor & Francis Group.

Duggleby, R.G., Guddat, L. W. and Pang, S. S. (2004). Structure and properties of acetohydroxyacid synthase. Thiamine. Catalytic Mechanisms. (pp. 251-274) edited by F. Jordan and M. S. Patel. USA: Marcel Dekker.

Guddat, Luke and Martin, Jennifer Louise (1997). Structure of DsbA. Guidebook to molecular chaperones and protein-folding catalysts. (pp. x-xx) Oxford (U.K.): Oxford Universit Press.

Journal Articles

Cheng, Yan, Wang, Yuan, Lonhienne, Thierry, Wang, Jian-Guo and Guddat, Luke W. (2024). Crystal Structures of Arabidopsis thaliana Acetohydroxyacid Synthase in Complex with the Herbicide Triasulfuron and Two Analogues with Herbicidal Activity in Field Trials. Journal of Agricultural and Food Chemistry, 72 (41), 22487-22498. doi: 10.1021/acs.jafc.4c04990

Xu, Qing, Gao, Yanhua, Sun, Zhongjie, Shi, Jin-Rui, Tang, Jin-Yin, Wang, Yuan, Liu, Yun, Sun, Xue-Wen, Li, Hao-Ran, Lonhienne, Thierry G., Niu, Cong-Wei, Li, Yong-Hong, Guddat, Luke W. and Wang, Jian-Guo (2024). Chemical Synthesis, Herbicidal Activity, Crop Safety, and Molecular Basis of ortho-Fluoroalkoxy Substituted Sulfonylureas as Novel Acetohydroxyacid Synthase Inhibitors. Journal of Agricultural and Food Chemistry, 72 (41), 22595-22605. doi: 10.1021/acs.jafc.4c05201

Wang, Quan, Wang, Tao, Cao, Lin, Mu, An, Fu, Sheng, Wang, Peipei, Gao, Yan, Ji, Wenxin, Liu, Zhenyu, Du, Zhanqiang, Guddat, Luke W., Zhang, Wenchi, Li, Shuang, Li, Xuemei, Lou, Zhiyong, Wang, Xiangxi, Hu, Zhongyu and Rao, Zihe (2024). Inherent symmetry and flexibility in hepatitis B virus subviral particles. Science, 385 (6714), 1217-1224. doi: 10.1126/science.adp1453

Wang, Yinan, Gao, Shan, Wu, Fangyu, Gong, Yicheng, Mu, Nengjiang, Wei, Chuancun, Wu, Chengyao, Wang, Jun, Yan, Ning, Yang, Huifang, Zhang, Yifan, Liu, Jiayi, Wang, Zeyu, Yang, Xiuna, Lam, Sin Man, Shui, Guanghou, Li, Siyuan, Da, Lintai, Guddat, Luke W., Rao, Zihe and Zhang, Lu (2024). Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance. Proceedings of the National Academy of Sciences, 121 (37) e2403421121, e2403421121. doi: 10.1073/pnas.2403421121

Zhang, Yuying, Lai, Yuezheng, Zhou, Shan, Ran, Ting, Zhang, Yue, Zhao, Ziqing, Feng, Ziyan, Yu, Long, Xu, Jinxu, Shi, Kun, Wang, Jianyun, Pang, Yu, Li, Liang, Chen, Hongming, Guddat, Luke W., Gao, Yan, Liu, Fengjiang, Rao, Zihe and Gong, Hongri (2024). Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631 (8020), 1-6. doi: 10.1038/s41586-024-07605-8

Wang, Haofeng, Liu, Xiaoce, Zhang, Xiang, Zhao, Zhuoqian, Lu, Yuchi, Pu, Dingzhe, Zhang, Zeyang, Chen, Jie, Wang, Yajie, Li, Mengfei, Dong, Xuxue, Duan, Yinkai, He, Yujia, Mao, Qiyu, Guo, Hangtian, Sun, Haoran, Zhou, Yihan, Yang, Qi, Gao, Yan, Yang, Xiuna, Cao, Hongzhi, Guddat, Luke, Sun, Lei, Rao, Zihe and Yang, Haitao (2024). TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 187 (16), 4261-4271.e17. doi: 10.1016/j.cell.2024.06.016

Keough, Dianne T., Petrová, Magdalena, King, Gordon, Kratochvíl, Michal, Pohl, Radek, Doleželová, Eva, Zíková, Alena, Guddat, Luke W. and Rejman, Dominik (2024). Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. Journal of Medicinal Chemistry, 67 (9), 7158-7175. doi: 10.1021/acs.jmedchem.4c00021

Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958

Yang, Xiaolin, Hu, Tianyu, Liang, Jingxi, Xiong, Zhiqi, Lin, Zhenli, Zhao, Yao, Zhou, Xiaoting, Gao, Yan, Sun, Shan, Yang, Xiuna, Guddat, Luke W., Yang, Haitao, Rao, Zihe and Zhang, Bing (2024). An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality. Nature Structural & Molecular Biology, 31 (7), 1-11. doi: 10.1038/s41594-024-01256-z

Hu, Tianyu, Yang, Xiaolin, Zhu, Yuanchen, Liu, Fengjiang, Yang, Xiuna, Xiong, Zhiqi, Liang, Jingxi, Lin, Zhenli, Ran, Yuting, Guddat, Luke W., Rao, Zihe and Zhang, Bing (2024). Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD. Science Advances, 10 (12) eadk8521, eadk8521. doi: 10.1126/sciadv.adk8521

Barbhuiya, Tabassum Khair, Beard, Sam, Shah, Esha T., Mason, Steven, Bolderson, Emma, O’Byrne, Ken, Guddat, Luke W., Richard, Derek J., Adams, Mark N. and Gandhi, Neha S. (2024). Targeting the hSSB1-INTS3 interface: a computational screening driven approach to identify potential modulators. ACS Omega, 9 (7), 8362-8373. doi: 10.1021/acsomega.3c09267

Wang, Haofeng, Yang, Qi, Liu, Xiaoce, Xu, Zili, Shao, Maolin, Li, Dongxu, Duan, Yinkai, Tang, Jielin, Yu, Xianqiang, Zhang, Yumin, Hao, Aihua, Wang, Yajie, Chen, Jie, Zhu, Chenghao, Guddat, Luke, Chen, Hongli, Zhang, Leike, Chen, Xinwen, Jiang, Biao, Sun, Lei, Rao, Zihe and Yang, Haitao (2023). Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nature Communications, 14 (1) 7574, 1-14. doi: 10.1038/s41467-023-42527-5

Sun, Xue-Wen, Liu, Yixuan, Wang, Xiaofang, Li, Hao-Ran, Lin, Xin, Tang, Jin-Yin, Xu, Qing, Agnew-Francis, Kylie A., Fraser, James A., Sun, Zhi-Juan, Guddat, Luke W. and Wang, Jian-Guo (2023). Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris. Chemical Biology & Drug Design, 103 (1) e14364, e14364. doi: 10.1111/cbdd.14364

Liang, Jingxi, Yang, Xiuna, Hu, Tianyu, Gao, Yan, Yang, Qi, Yang, Haitao, Peng, Wei, Zhou, Xiaoting, Guddat, Luke W., Zhang, Bing, Rao, Zihe and Liu, Fengjiang (2023). Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31 (10), 1158-1165.e3. doi: 10.1016/j.str.2023.07.014

Liang, Jingxi, Liu, Fengjiang, Xu, Peng, Shangguan, Wei, Hu, Tianyu, Wang, Shule, Yang, Xiaolin, Xiong, Zhiqi, Yang, Xiuna, Guddat, Luke W., Yu, Biao, Rao, Zihe and Zhang, Bing (2023). Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC. Proceedings of the National Academy of Sciences, 120 (35) e2307625120, 1-9. doi: 10.1073/pnas.2307625120

Vaňková, Karolína, Keough, Dianne T., Hocková, Dana, Guddat, Luke W. and Janeba, Zlatko (2023). N2' ‐branched acyclic nucleoside phosphonates containing 9‐deazahypoxanthine as inhibitors of Plasmodium falciparum 6‐oxopurine phosphoribosyltransferase. ChemMedChem, 18 (15) e202300211, e202300211. doi: 10.1002/cmdc.202300211

Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383

Sun, Shan, Gao, Yan, Yang, Xiaolin, Yang, Xiuna, Hu, Tianyu, Jingxi, Liang, Xiong, Zhiqi, Ran, Yuting, Ren, Pengxuan, Bai, Fang, Guddat, Luke W, Yang, Haitao, Rao, Zihe and Zhang, Bing (2023). Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB. Protein and Cell, 14 (6), 448-458. doi: 10.1093/procel/pwac060

Lai, Yuezheng, Zhang, Yuying, Zhou, Shan, Xu, Jinxu, Du, Zhanqiang, Feng, Ziyan, Yu, Long, Zhao, Ziqing, Wang, Weiwei, Tang, Yanting, Yang, Xiuna, Guddat, Luke W., Liu, Fengjiang, Gao, Yan, Rao, Zihe and Gong, Hongri (2023). Structure of the human ATP synthase. Molecular Cell, 83 (12), 2137-2147.e4. doi: 10.1016/j.molcel.2023.04.029

Zhu, Chen, Shi, Yanfeng, Yu, Jing, Zhao, Wenhao, Li, Lingqiao, Jingxi, Liang, Yang, Xiaolin, Zhang, Bing, Zhao, Yao, Gao, Yan, Chen, Xiaobo, Yang, Xiuna, Zhang, Lu, Guddat, Luke W., Liu, Lei, Yang, Haitao, Rao, Zihe and Li, Jun (2023). Cryo-EM structures of a prokaryotic heme transporter CydDC. Protein and Cell, 14 (12), 919-923. doi: 10.1093/procel/pwad022

Du, Zhanqiang, Zhou, Xiaoting, Lai, Yuezheng, Xu, Jinxu, Zhang, Yuying, Zhou, Shan, Feng, Ziyan, Yu, Long, Tang, Yanting, Wang, Weiwei, Yu, Lu, Tian, Changlin, Ran, Ting, Chen, Hongming, Guddat, Luke W., Liu, Fengjiang, Gao, Yan, Rao, Zihe and Gong, Hongri (2023). Structure of the human respiratory complex II. Proceedings of the National Academy of Sciences, 120 (18) e2216713120, e2216713120. doi: 10.1073/pnas.2216713120

Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528

Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140

Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x

Yan, Liming, Huang, Yucen, Ge, Ji, Liu, Zhenyu, Lu, Pengchi, Huang, Bo, Gao, Shan, Wang, Junbo, Tan, Liping, Ye, Sihan, Yu, Fengxi, Lan, Weiqi, Xu, Shiya, Zhou, Feng, Shi, Lei, Guddat, Luke W., Gao, Yan, Rao, Zihe and Lou, Zhiyong (2022). A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185 (23), 4347-4360. doi: 10.1016/j.cell.2022.09.037

Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633

Hu, Tianyu, Yang, Xiaolin, Liu, Fengjiang, Sun, Shan, Xiong, Zhiqi, Liang, Jingxi, Yang, Xiaobao, Wang, Haofeng, Yang, Xiuna, Guddat, Luke W., Yang, Haitao, Rao, Zihe and Zhang, Bing (2022). Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30 (10), 1395-1402.e4. doi: 10.1016/j.str.2022.07.009

Lv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073

Bayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927

Zhao, Yao, Zhu, Yan, Liu, Xiang, Jin, Zhenming, Duan, Yinkai, Zhang, Qi, Wu, Chengyao, Feng, Lu, Du, Xiaoyu, Zhao, Jinyi, Shao, Maolin, Zhang, Bing, Yang, Xiuna, Wu, Lijie, Ji, Xiaoyun, Guddat, Luke W., Yang, Kailin, Rao, Zihe and Yang, Haitao (2022). Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proceedings of the National Academy of Sciences, 119 (16) e2117142119, 1-9. doi: 10.1073/pnas.2117142119

Lonhienne, Thierry, Garcia, Mario Daniel, Low, Yu Shang and Guddat, Luke W. (2022). Herbicides that inhibit acetolactate synthase. Frontiers of Agricultural Science and Engineering, 9 (1), 155-160. doi: 10.15302/J-FASE-2021420

Klejch, Tomáš, Keough, Dianne T., King, Gordon, Doleželová, Eva, Česnek, Michal, Buděšínský, Miloš, Zíková, Alena, Janeba, Zlatko, Guddat, Luke W. and Hocková, Dana (2022). Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 65 (5), 4030-4057. doi: 10.1021/acs.jmedchem.1c01881

Zhang, Qingqing, Liu, Xiang, Liu, Huijuan, Zhang, Bingjie, Yang, Haitao, Mi, Kaixia, Guddat, Luke W. and Rao, Zihe (2021). Conformational changes in a macrolide antibiotic binding protein from Mycobacterium smegmatis upon ADP binding. Frontiers in Microbiology, 12 780954, 780954. doi: 10.3389/fmicb.2021.780954

Gong, Hongri, Gao, Yan, Zhou, Xiaoting, Xiao, Yu, Wang, Weiwei, Tang, Yanting, Zhou, Shan, Zhang, Yuying, Ji, Wenxin, Yu, Lu, Tian, Changlin, Lam, Sin Man, Shui, Guanghou, Guddat, Luke W., Wong, Luet-Lok, Wang, Quan and Rao, Zihe (2021). Author Correction: Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF (Nature Communications, (2020), 11, 1, (4245), 10.1038/s41467-020-18011-9). Nature Communications, 12 (1) 1370, 1370. doi: 10.1038/s41467-021-21616-3

Low, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9

Zhou, Shan, Wang, Weiwei, Zhou, Xiaoting, Zhang, Yuying, Lai, Yuezheng, Tang, Yanting, Xu, Jinxu, Li, Dongmei, Lin, Jianping, Yang, Xiaolin, Ran, Ting, Chen, Hongming, Guddat, Luke W, Wang, Quan, Gao, Yan, Rao, Zihe and Gong, Hongri (2021). Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. eLife, 10 e69418. doi: 10.7554/elife.69418

Wilson, Liam A., Knaven, Esmée G., Morris, Marc T., Monteiro Pedroso, Marcelo, Schofield, Christopher J., Brück, Thomas, Boden, Mikael, Waite, David W., Hugenholtz, Philip, Guddat, Luke and Schenk, Gerhard (2021). Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid. Antimicrobial Agents and Chemotherapy, 65 (10) e00936-21, e0093621. doi: 10.1128/aac.00936-21

Feder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486

Wang, Weiwei, Gao, Yan, Tang, Yanting, Zhou, Xiaoting, Lai, Yuezheng, Zhou, Shan, Zhang, Yuying, Yang, Xiuna, Liu, Fengjiang, Guddat, Luke W., Wang, Quan, Rao, Zihe and Gong, Hongri (2021). Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Nature Communications, 12 (1) 4621, 1-8. doi: 10.1038/s41467-021-24924-w

Frydrych, Jan, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Dračínský, Martin, Edstein, Michael D., Guddat, Luke W., Hocková, Dana and Janeba, Zlatko (2021). Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity. European Journal of Medicinal Chemistry, 219 113416, 1-18. doi: 10.1016/j.ejmech.2021.113416

Doleželová, Eva, Klejch, Tomáš, Špaček, Petr, Slapničková, Martina, Guddat, Luke, Hocková, Dana and Zíková, Alena (2021). Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro. Scientific Reports, 11 (1) 13317, 1-27. doi: 10.1038/s41598-021-91747-6

Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C., Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y., Guddat, Luke W., Gao, Yan, Rao, Zihe and Lou, Zhiyong (2021). Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184 (13), 3474-3485. doi: 10.1016/j.cell.2021.05.033

Keough, Dianne T., Wun, Shun Jie, Baszczyňski, Ondřej, Eng, Wai Soon, Špaček, Petr, Panjikar, Santosh, Naesens, Lieve, Pohl, Radek, Rejman, Dominik, Hocková, Dana, Ferrero, Richard L. and Guddat, Luke W. (2021). Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase - a putative target for drug discovery against gastrointestinal tract infections. Journal of Medicinal Chemistry, 64 (9), 5710-5729. doi: 10.1021/acs.jmedchem.0c02184

Zhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe and Yang, Haitao (2021). High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein and Cell, 12 (11), 877-888. doi: 10.1007/s13238-021-00836-9

Zhou, Xiaoting, Gao, Yan, Wang, Weiwei, Yang, Xiaolin, Yang, Xiuna, Liu, Fengjiang, Tang, Yanting, Lam, Sin Man, Shui, Guanghou, Yu, Lu, Tian, Changlin, Guddat, Luke W., Wang, Quan, Rao, Zihe and Gong, Hongri (2021). Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded rieske FeS cluster. Proceedings of the National Academy of Sciences of the United States of America, 118 (15) e2022308118, 1-6. doi: 10.1073/pnas.2022308118

Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665

Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919

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Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J. and Rao, Zihe (2020). Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation. Molecular Pharmacology, 97 (4), 287-294. doi: 10.1124/mol.119.118042

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Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611

Wang, Manfu, Guo, Xiangyang, Yang, Xiuna, Zhang, Bing, Ren, Jie, Liu, Aijun, Ran, Yajun, Yan, Bing, Chen, Fang, Guddat, Luke W., Hu, Junjie, Li, Jun and Rao, Zihe (2019). Mycobacterial dynamin-like protein IniA mediates membrane fission. Nature Communications, 10 (1) 3906, 3906. doi: 10.1038/s41467-019-11860-z

Terán, David, Doleželová, Eva, Keough, Dianne T., Hocková, Dana, Zíková, Alena and Guddat, Luke W. (2019). Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP. The FEBS Journal, 286 (23) febs.14987, 4721-4736. doi: 10.1111/febs.14987

Feder, Daniel, Gahan, Lawrence R., McGeary, Ross P., Guddat, Luke W. and Schenk, Gerhard (2019). The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state. ChemBioChem, 20 (12), 1536-1540. doi: 10.1002/cbic.201900077

Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019). Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 (5) e00704, e00704. doi: 10.1002/mbo3.704

Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Guddat, Luke W. and Sriram, Dharmarajan (2019). Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads. Journal of Computer-Aided Molecular Design, 33 (3), 357-366. doi: 10.1007/s10822-019-00184-1

Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019). Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 (6), 1451-1455. doi: 10.1002/chem.201805420

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Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019). Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 (1), 61-71. doi: 10.1039/c8md00491a

Wang, Shuhui, Zhou, Kaixuan, Yang, Xiaolin, Zhang, Bing, Zhao, Yao, Xiao, Yu, Yang, Xiuna, Yang, Haitao, Guddat, Luke W., Li, Jun and Rao, Zihe (2019). Structural insights into substrate recognition by the type VII secretion system. Protein and Cell, 11 (2), 124-137. doi: 10.1007/s13238-019-00671-z

Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, Hsin-Yung, Lam, Sin Man, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V., Wong, Luet-Lok, Guddat, Luke W., Sun, Fei, Wang, Quan and Rao, Zihe (2018). An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362 (6418) eaat8923, eaat8923-+. doi: 10.1126/science.aat8923

Eng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018). Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159, 10-22. doi: 10.1016/j.ejmech.2018.09.039

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Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115

Klejch, Tomáš, Pohl, Radek, Janeba, Zlatko, Sun, Minghan, Keough, Dianne T., Guddat, Luke W. and Hocková, Dana (2018). Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. Tetrahedron, 74 (40), 5886-5897. doi: 10.1016/j.tet.2018.08.014

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018). Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157, 462-479. doi: 10.1016/j.ejmech.2018.08.004

Doleželová, Eva, Terán, David, Gahura, Ondřej, Kotrbová, Zuzana, Procházková, Michaela, Keough, Dianne, Špaček, Petr, Hocková, Dana, Guddat, Luke and Zíková, Alena (2018). Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Neglected Tropical Diseases, 12 (2) e0006301, 1-28. doi: 10.1371/journal.pntd.0006301

Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2

Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018). Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 (9), E1945-E1954. doi: 10.1073/pnas.1714392115

Zhang, Qingqing, Liu, Huijuan, Liu, Xiang, Jiang, Dunquan, Zhang, Bingjie, Tian, Hongliang, Yang, Cheng, Guddat, Luke W., Yang, Haitao, Mi, Kaixia and Rao, Zihe (2018). Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein and Cell, 9 (11), 1-5. doi: 10.1007/s13238-017-0502-7

Patel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017). Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry- A European Journal, 23 (72), 18289-18295. doi: 10.1002/chem.201704481

Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism. Chemistryselect, 2 (36), 11981-11988. doi: 10.1002/slct.201702128

Keough, Dianne T., Rejman, Dominik, Pohl, Radek, Zborníková, Eva, Hocková, Dana, Croll, Tristan, Edstein, Michael D., Birrell, Geoff W., Chavchich, Marina, Naesens, Lieve M. J., Pierens, Gregory K., Brereton, Ian M. and Guddat, Luke W. (2017). Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chemical Biology, 13 (1), 82-90. doi: 10.1021/acschembio.7b00916

Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203

Yan, Qiaoling, Jiang, Dunquan, Qian, Lanfang, Zhang, Qingqing, Zhang, Wei, Zhou, Weihong, Mi, Kaixia, Guddat, Luke, Yang, Haitao and Rao, Zihe (2017). Structural insight into the activation of PknI kinase from M. tuberculosis via dimerization of the extracellular sensor domain. Structure, 25 (8), 1286-1294. doi: 10.1016/j.str.2017.06.010

Kaiser, Martin Maxmilian, Baszczynski, Ondrej, Hockova, Dana, Postova-Slavetinska, Lenka, Dracinsky, Martin, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases. ChemMedChem, 12 (14), 1133-1141. doi: 10.1002/cmdc.201700293

Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013

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Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866

Lukáč, Miloš, Hocková, Dana, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases. Tetrahedron, 73 (6), 692-702. doi: 10.1016/j.tet.2016.12.046

Lonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 (2) e0171443, e0171443.1-e0171443.13. doi: 10.1371/journal.pone.0171443

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Teran, David, Hockova, Dana, Cesnek, Micha, Zikova, Alena, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016). Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Scientific Reports, 6 (1) 35894, 35894. doi: 10.1038/srep35894

Schenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53.

Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620

Du, Qianyun Sharon, Trabi, Manuela, Richards, Renee Stirling, Mirtschin, Peter, Madaras, Frank, Nouwens, Amanda, Zhao, Kong-Nan, De Jersey, John, Lavin, Martin F., Guddat, Luke W. and Masci, Paul P. (2016). Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom. Toxicon, 111, 37-49. doi: 10.1016/j.toxicon.2015.12.017

Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985

You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672

Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985

Kaiser, Martin M., Hocková, Dana, Wang, Tzu-Hsuan, Dračínský, Martin, Poštová-Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2015). Synthesis and evaluation of novel acyclic nucleoside phosphonates as inhibitors of Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases. ChemMedChem, 10 (10), 1707-1723. doi: 10.1002/cmdc.201500322

Hockova, Dana, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T. and Guddat, Luke W. (2015). Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 23 (17), 5502-5510. doi: 10.1016/j.bmc.2015.07.038

Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611

Pohl, Radek, Slavetinska, Lenka Postova, Eng, Wai Soon, Keough, Dianne T., Guddat, Luke W. and Rejman, Dominik (2015). Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Organic and Biomolecular Chemistry, 13 (16), 4693-4705. doi: 10.1039/c5ob00097a

Keough, Dianne T., Hockova, Dana, Janeba, Zlatko, Wang, Tzu-Hsuan, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina and Guddat, Luke W. (2015). Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. Journal of Medicinal Chemistry, 58 (2), 827-846. doi: 10.1021/jm501416t

McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014). The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76, 132-144. doi: 10.1016/j.ejmech.2014.02.008

Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014). Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 (3), 389-398. doi: 10.1007/s00775-013-1079-0

Batten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014). International Year of Crystallography. Australian Journal of Chemistry, 67 (12), 1718-1719. doi: 10.1071/CH14557

Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013). Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 (4), 615-629. doi: 10.1124/mol.113.087247

Baszczynski, Ondrej, Hockova, Dana, Janeba, Zlatko, Holy, Antonin, Jansa, Petr, Dracinsky, Martin, Keough, Dianne T. and Guddat, Luke W. (2013). The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry, 67, 81-89. doi: 10.1016/j.ejmech.2013.06.032

Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013). Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 (17), 6967-6984. doi: 10.1021/jm400779n

Pue, Nason and Guddat, Luke W. (2013). Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 (5), 1-17. doi: 10.2174/13816128113199990009

Keough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013). Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 (6), 2513-2526. doi: 10.1021/jm301893b

Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013). Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 (1), 210-219. doi: 10.1021/jm301501k

Millers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013). The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 (1) e54104, e54104.1-e54104.12. doi: 10.1371/journal.pone.0054104

Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001

Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012). Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 (3-4), 168-179. doi: 10.1016/j.jmb.2012.09.018

Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012). Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 (9), 1593-1603. doi: 10.1021/ar300067g

Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012). A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 (19), 6190-6194. doi: 10.1016/j.bmcl.2012.08.001

Hockova, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2012). Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 55 (13), 6209-6223. doi: 10.1021/jm300662d

Li, Zheng-Ming, Ma, Yi, Guddat, Luke, Cheng, Pei-Quan, Wang, Jian-Guo, Pangi, Siew S., Dong, Yu-Hui, Lai, Cheng-Ming, Wang, Ling-Xiu, Jia, Guo-Feng, Li, Yong-Hong, Wang, Su-Hua, Liu, Jie, Zhao, Wei-Guang and Wang, Bao Lei (2012). The structure-activity relationship in herbicidal monosubstituted sulfonylureas. Pest Management Science, 68 (4), 618-628. doi: 10.1002/ps.2305

Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123

Krecmerova, Marcela, Dracinsky, Martin, Hockova, Dana, Holy, Antonín, Keough, Dianne T. and Guddat, Luke W. (2012). Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry, 20 (3), 1222-1230. doi: 10.1016/j.bmc.2011.12.034

Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015

Cesnek, Michael, Hockova, Dana, Holy, Antonín, Dracinsky, Martin, Baszczynski, Ondřej, de Jersey, John, Keough, Dianne T. and Guddat, Luke W. (2011). Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 20 (2), 1076-1089. doi: 10.1016/j.bmc.2011.11.034

Wang, Jianguo, Tan, Haizhong, Li, Yonghong, Ma, Yi, Li, Zhengming and Guddat, Luke W. (2011). Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. Journal of Agricultural and Food Chemistry, 59 (18), 9892-9900. doi: 10.1021/jf2021607

de Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011). 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 (16), 2085-2102. doi: 10.2174/156802611796575911

Guddat, L (2011). Drug targets for the treatment of protozoan parasitic diseases. Current Topics in Medicinal Chemistry, 11 (16), 2010-2011. doi: 10.2174/156802611796575920

Keough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010). Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 (2), 165-169. doi: 10.1016/j.molbiopara.2010.05.018

Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054

Hockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009). Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 (17), 6218-6232. doi: 10.1016/j.bmc.2009.07.044

Keough, Dianne T., Hockova, Dana, Holy, Antonin, Naesens, Lieve M. J., Skinner-Adams, Tina S., de Jersey, John and Guddat, Luke W. (2009). Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry, 52 (14), 4391-4399. doi: 10.1021/jm900267n

Millers, Emma-Karin K., Trabi, Manuela, Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2009). Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS Journal, 276 (11), 3163-3175. doi: 10.1111/j.1742-4658.2009.07034.x

Leung, Eleanor W. W. and Guddat, Luke W. (2009). Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures. Journal of Molecular Biology, 389 (1), 167-182. doi: 10.1016/j.jmb.2009.04.012

Wang, Jian-Guo, Lee, Patrick K.-M., Dong, Yu-Hui, Pang, Siew Siew, Duggleby, Ronald G., Li, Zheng-Ming and Guddat, Luke W. (2009). Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS Journal, 276 (5), 1282-1290. doi: 10.1111/j.1742-4658.2009.06863.x

McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009). Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 (1), 163-166. doi: 10.1016/j.bmcl.2008.10.125

Hadler, K., Tanifum, E.A., Yip, S.H.-C., Mitic, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A. and Schenk, G. (2008). Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 (43), 14129-14138. doi: 10.1021/ja803346w

Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78

Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008). Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6) 6, 1-13. doi: 10.1186/1472-6807-8-6

Duggleby, R.G., McCourt, J.A. and Guddat, Luke W. (2008). Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiology and Biochemistry, 2008 (46), 309-324. doi: 10.1016/j.plaphy.2007.12.004

Kim, M., Hamilton, S. E., Guddat, L. W. and Overall, C. M. (2007). Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger. Biochimica Et Biophysica Acta General Subjects, 1770 (12), 1627-1635. doi: 10.1016/j.bbagen.2007.08.003

Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007). Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8, 21-31.

Keough, Dianne T., Skinner-Adams, Tina, Jones, Malcolm K., Ng, Ai-Lin., Brereton, Ian M., Guddat, Luke W. and de Jersey, John (2006). Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 49 (25), 7479-7486. doi: 10.1021/jm061012j

Zheng, Yuan-Zhi, Guddat, Luke, Farlow, Anthony and de Jersey, John (2006). Structure-function relationships in human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) by random mutagenesis. Chemical Research in Chinese Universities, 22 (2), 251-252. doi: 10.1016/S1005-9040(06)60090-1

Millers, E. K. I., Masci, P. P., Lavin, M. F., de Jersey, J. and Guddat, L. W. (2006). Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (Pt 7), 642-645. doi: 10.1107/S1744309106019099

Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W. and Schenk, G. (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Journal of the Brazilian Chemical Society, 17 (8), 1558-1565. doi: 10.1590/S0103-50532006000800011

Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006). The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 (8), 3338-3363. doi: 10.1021/cr050318f

De Jersey, J., Zheng, Yuan-Zhi, Fan, H. K., Schenk, G., Guddat, L. and Hamilton, S. (2006). Mammalian-like purple acid phosphatases in plants. Chemical Research In Chinese Universities, 22 (2), 263-264. doi: 10.1016/S1005-9040(06)60093-7

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R. G. (2006). Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase. Proceedings of The National Academy of Sciences of The United States of America, 103 (3), 569-573. doi: 10.1073/pnas.0508701103

Tyagi, R., Duquerroy, S., Navaza, J., Guddat, L. W. and Duggleby, R. G. (2005). The crystal structure of a bacterial Class II ketol-acid reductolsomerase: Domain conservation and evolution. Protein Science, 14 (12), 3089-3100. doi: 10.1110/ps.051791305

Wang, Jian-Guo, Li, Zheng-Ming, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Pang, Siew Siew, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005). Structure-activity relationships for a new family of sulfonylurea herbicides. Journal of Computer-aided Molecular Design, 19 (11), 801-820. doi: 10.1007/s10822-005-9028-9

Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, James S. and Andrews, Katherine T. (2005). Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply. Journal of Infectious Diseases, 191 (8), 1382-1383. doi: 10.1086/428782

Savarino, Andrea, Cauda, Roberto, Cassone, Antonio, Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, J. James S. and Andrews, Katherine T. (2005). Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors [3] (multiple letters). Journal of Infectious Diseases, 191 (8), 1381-1383. doi: 10.1086/428781

Tyagi, Rajiv, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005). Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Febs Journal, 272 (2), 593-602. doi: 10.1111/j.1742-4658.2004.04506.x

McCourt, J. A., Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2005). Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry, 44 (7), 2330-2338. doi: 10.1021/bi047980a

Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., de Jersey, J. and Guddat, L. W. (2005). Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proceedings of The National Academy of Sciences of The United States of America, 102 (2), 273-278. doi: 10.1073/pnas.0407239102

Keough, Dianne T., Brereton, Ian M., De Jersey, John and Guddat, Luke W. (2005). The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. Journal of Molecular Biology, 351 (1), 170-181. doi: 10.1016/j.jmb.2005.05.061

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008

Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2004). Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta Crystallographica Section D: Biological Crystallography, 60 (1), 153-155. doi: 10.1107/S0907444903025423

McCourt, J. A., Tyagi, R., Guddat, L. W., Biou, V. and Duggleby, R. G. (2004). Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallographica Section D: Biological Crystallography, 60 (8), 1432-1434. doi: 10.1107/S0907444904012247

Pang, S. S., Duggleby, R. G., Schowen, R. L. and Guddat, L. W. (2004). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. Journal of Biological Chemistry, 279 (3), 2242-2253. doi: 10.1074/jbc.M304038200

Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003). Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 (13), 2895-2904. doi: 10.1046/j.1432-1033.2003.03671.x

Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. Journal of Biological Chemistry, 278 (9), 7639-7644. doi: 10.1074/jbc.M211648200

Pang, S. S., Duggleby, R. G. and Guddat, L. W. (2002). Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors. Journal of Molecular Biology, 317 (2), 249-262. doi: 10.1006/jmbi.2001.5419

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae. Acta Crystallographica Section D - Biological Crystallography, D58 (7), 1237-1239. doi: 10.1107/S0907444902008132

Bourne, P. C., Ramsland, P. A., Shan, L., Fan, Z. C., DeWitt, C. R., Shultz, B. B., Terzyan, S. S., Moomaw, C. R., Slaughter, C. A., Guddat, L. W. and Edmundson, A. B. (2002). Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallographica Section D: Biological Crystallography, 58 (5), 815-823. doi: 10.1107/S0907444902004183

Guddat, L. W., Vos, S., Martin, J. L., Keough, D. T. and De Jersey, J. (2002). Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Science, 11 (7), 1626-1638. doi: 10.1110/ps.0201002

Edeling, M. A., Guddat, L. W., Fabianek, R. A., Thony-Meyer, L. and Martin, J. L. (2002). Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment. Structure, 10 (7), 973-979. doi: 10.1016/S0969-2126(02)00794-3

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2001). Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase. Acta Crystallographica Section D: Biological Crystallography, 57 (9), 1321-1323. doi: 10.1107/S0907444901011635

Edeling, M. A., Guddat, L. W., Fabianek, R. A., Halliday, J. A., Jones, A., Thony-Meyer, L. and Martin, J. L. (2001). Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE). Acta Crystallographica Section D-Biological Crystallography, D57 (9), 1293-1295. doi: 10.1107/S0907444901009982

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9

Guddat, Luke W., Shan, Lin, Broomell, Christopher, Ramsland, Paul A., Fan, Zhao-Chang, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (2000). The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): An illustration of structural diversity in antigen recognition by immunoglobulins. Journal of Molecular Biology, 302 (4), 853-872. doi: 10.1006/jmbi.2000.4083

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

P.A.Ramsland P.A.RamslandPaul A.P.A.Ramsland P.RamslandPaul A.https://api.elsevier.com/content/author/author_id/7004592319 (2000). An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands. Molecular Immunology, 37 (6), 295-310. doi: 10.1016/S0161-5890(00)00049-3

Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999). Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 (12), 2051-2052. doi: 10.1107/S0907444999012597

Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J., Hamilton, S. E. and Martin, J. L. (1999). Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase. Acta Crystallographica Section D: Biological Crystallography, 55 (8), 1462-1464. doi: 10.1107/S0907444999006241

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E., De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase. Structure With Folding & Design, 7 (7), 757-767. doi: 10.1016/S0969-2126(99)80100-2

Fan, Zhao-Chang, Shan, Lin, Goldsteen, Benjamin Z., Guddat, Luke W., Thakur, Archana, Landolfi, Nicholas F., Co, Man Sung, Vasquez, Maximiliano, Queen, Cary, Ramsland, Paul A. and Edmundson, Allen B. (1999). Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-γ-interferon antibody. Journal of Molecular Recognition, 12 (1), 19-32. doi: 10.1002/(SICI)1099-1352(199901/02)12:1<19::AID-JMR445>3.0.CO;2-Y

Guddat, LW, Bardwell, JCA and Martin, JL (1998). Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization. Structure, 6 (6), 757-767. doi: 10.1016/S0969-2126(98)00077-X

Faber, Catherine, Shan, Lin, Fan, Zhao-Chang, Guddat, Luke W., Furebring, Christina, Ohlin, Mats, Borrebaeck, Carl A.K. and Edmundson, Allen B. (1998). Three-dimensional structure of a human Fab with high affinity for tetanus toxoid. Immunotechnology, 3 (4), 253-270. doi: 10.1016/S1380-2933(97)10003-3

Guddat, LW, Bardwell, JCA, Glockshuber, R, HuberWunderlich, M, Zander, T and Martin, JL (1997). Structural analysis of three His32 mutants of DsbA: Support for an electrostatic role of His32 in DsbA stability. Protein Science, 6 (9), 1893-1900. doi: 10.1002/pro.5560060910

Guddat, LW, Bardwell, JCA, Zander, T and Martin, JL (1997). The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding. Protein Science, 6 (6), 1148-1156. doi: 10.1002/pro.5560060603

P.A.Ramsland P.A.RamslandPaul A.P.A.Ramsland P.RamslandPaul A.https://api.elsevier.com/content/author/author_id/7004592319 (1997). Diverse binding site structures revealed in homology models of polyreactive immunoglobulins. Journal of Computer-Aided Molecular Design, 11 (5), 453-461. doi: 10.1023/A:1007932211514

Guddat, LW, Martin, JL, Shan, L, Edmundson, AB and Gray, WR (1996). Three-dimensional structure of the alpha-conotoxin GI at 1.2 angstrom resolution. Biochemistry, 35 (35), 11329-11335. doi: 10.1021/bi960820h

Hu, Shu-Hong, Gehrmann, John, Guddat, Luke W., Alewood, Paul F., Craik, David J. and Martin, Jennifer L. (1996). The 1.1 angstrom crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus. Structure, 4 (4), 417-423. doi: 10.1016/S0969-2126(96)00047-0

Edmundson, Allen B., Shan, Lin, Fan, Zhao-Chang, Guddat, Luke W., Hanson, B. Leif and Andersen, Kim N. (1996). Crystallographic analysis of antigen-antibody complexes: End-on insertion of ligands in antibodies - CDR3 loops as arbiters. Methods: A Companion to Methods in Enzymology, 9 (3), 542-558. doi: 10.1006/meth.1996.0062

Guddat, L. W., Shan, L., Fan, Z. C., Andersen, K. N., Linthicum, , Rosauer, R., Linthicum, D. S. and Edmundson, A. B. (1995). Intramolecular signaling upon complexation. FASEB Journal, 9 (1), 101-106.

Guddat, Luke W., Shan, Lin, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (1994). Local and transmitted conformational changes on complexation of an anti-sweetener Fab. Journal of Molecular Biology, 236 (1), 247-274. doi: 10.1006/jmbi.1994.1133

Herron, J. N., Terry, A. H., Johnston, S., He, X. M., Guddat, L. W., Voss, E. W. and Edmundson, A. B. (1994). High resolution structures of the 4–4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. Biophysical Journal, 67 (6), 2167-2183. doi: 10.1016/S0006-3495(94)80738-6

Edmundson, A. B., Guddat, L. W., Shan, L., Fan, Z. c. and Hanson, B. L. (1994). Structural aspects of conformational changes in ligand binding by antibody fragments. Research in Immunology, 145 (1), 56-61. doi: 10.1016/S0923-2494(94)80045-6

Edmundson, Allen B., Guddat, Luke W. and Andersen, Kim N. (1993). Crystal Structures of Intact IgG Antibodies. ImmunoMethods, 3 (3), 197-210. doi: 10.1006/immu.1993.1054

Shan, L., Guddat, L. W., Raison, R. L. and Edmundson, A. B. (1993). Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique. Journal of Crystal Growth, 126 (2-3), 229-244. doi: 10.1016/0022-0248(93)90030-Z

Edmundson, A. B., Harris, D. L., Fan, Z. ‐C, Guddat, L. W., Schley, B. T., Hanson, B. L., Tribbick, G. and Geysen, H. M. (1993). Principles and pitfalls in designing site‐directed peptide ligands. Proteins: Structure, Function, and Bioinformatics, 16 (3), 246-267. doi: 10.1002/prot.340160304

Guddat, L. W., Herron, J. N. and Edmundson, A. B. (1993). Three-dimensional structure of a human immunoglobulin with a hinge deletion. Proceedings of the National Academy of Sciences of the United States of America, 90 (9), 4271-4275. doi: 10.1073/pnas.90.9.4271

Fan, Zhao-chang, Shan, Lin, Guddat, Luke W., He, Xiao-min, Gray, William R., Raison, Robert L. and Edmundson, Allen B. (1992). Three-dimensional structure of an Fv from a human IgM immunoglobulin. Journal of Molecular Biology, 228 (1), 188-207. doi: 10.1016/0022-2836(92)90500-J

Deacon, G. B., Gatehouse, B. M., Guddat, L. W. and Ney, S. C. (1989). Difunctionalization of primary aromatic amines with ethylene; synthesis of μ-arylnitrilobis(ethane-2,1-diyl)dimercury(II) complexes. Crystal structure of 2,4,6-Me3C6H2N-(CH2CH2HgCl)2 . Journal of Organometallic Chemistry, 375 (1), C1-C4. doi: 10.1016/0022-328X(89)85095-8

Orbell, John D., Guddat, Luke W., Machin, Ken J. and Isaacs, Neil W. (1988). The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment. Analytical Biochemistry, 170 (2), 390-392. doi: 10.1016/0003-2697(88)90649-5

Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987). CRYSTAL STRUCTURE OF Ba//3V//4O//1//3. CHEMTECH, 17 (8), 390-395.

Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987). The crystal structure of Ba3V4O13. Journal of Solid State Chemistry, 71 (2), 390-395. doi: 10.1016/0022-4596(87)90247-7

Fallon, G. D., Gatehouse, B. M. and Guddat, L. (1986). Crystal structures of some niobium and tantalum oxides. IX. K3Nb7O19: A new potassium niobium oxide tunnel structure. Journal of Solid State Chemistry, 61 (2), 181-187. doi: 10.1016/0022-4596(86)90020-4

Guddat, L. W., Cowan, S. W., Machin, K. J., Isaacs, N. W. and Cotton, R. G H (1985). Crystallization and preliminary crystallographic data of the fab fragment of an anti-phenylalanine hydroxylase monoclonal antibody. Journal of Molecular Biology, 186 (2), 479-480. doi: 10.1016/0022-2836(85)90121-4

Conference Papers

Cheng, Yan, Lonhienne, Thierry, Garcia, Mario, Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2023). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085571

Guddat, Luke W. (2023). Acetohydroxyacid synthase: structure, function, regulation and inhibition. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323095050

Gao, Yanhua, Wu, Shunjie, Lonhienne, Thierry, Lin, Xin and Guddat, Luke (2023). Investigations of Mycobacterium tuberculosis acetohydroxyacid synthases as therapeutic drug targets. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085583

Zhao, Qi, Cheng, Yan, Lonhienne, Thierry and Guddat, Luke W. (2023). Structural investigation of two commercial herbicides that target acetohydroxyacid synthase. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s205327332308556x

Ge, Xiaoling, Lonhienne, Thierry, Garcia, Mario D. and Guddat, Luke W. (2023). Targeting acetohydroxyacid synthase to discover new therapeutics for Cryptococcus neoformans infections. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085546

Schenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, 31 July - 4 August 2017. New York, NY United States: Springer.

Elliott, Tristan W., Mitić, Nataša, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Sociedade Brasileira de Quimica. doi: 10.1590/S0103-50532006000800011

Millers, E. I., Masci, P., Lavin, M. F., De Jersey, J. and Guddat, L. W. (2005). Crystal structure of textilinin-1. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

Duggleby, R.G., Tyagi, R., Duquerroy, S., Navaza, J. and Guddat, L. W. (2005). Crystal structure of Escherichia coli ketol-acid reductoisomerase. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Overlapping sulfonylurea and imidazolinone herbicide binding sites in Arabidopsis thaliana acetohydroxyacid synthase. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana. 30th Annual Lorne Conference on Protein Structure and Function, Lorne, 6-11 Feb, 2005.

Duggleby, R.G., McCourt, J. A. and Guddat, L. W. (2005). 3D structure of the overlapping sulfonylurea and imidazolinone herbicide binding sites in acetohydroxyacid synthase. 9th Int Congress on Amino Acids & Proteins, Vienna, 8-12 Aug, 2005.

Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.

Duggleby, R.G., Pang, S. S., Schowen, R. L. and Guddat, L. W. (2003). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD. 14th Int Symposium on Flavins and Flavoproteins, Cambridge, UK, 14-18 July, 2002.

Keough, D. T., Dulley, G., Guddat, L. W., Naesens, L. and De Jersey, J. (2002). Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. ComBio 2002, Sydney, 29 September - 3 October, 2002.

Landsberg, M., Guddat, L. W., Hawkins, B. L. and Smith, R. W. (2001). Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element. ASBMB, Canberra, 31 Sept-4 Oct, 2001.

Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. EUROBIC-5, Toulouse, France, 17-20 July 2000.

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., 7-11 February, 1999. Lorne: Lorne Aust..

Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Dulley, G., Ng, A., Qi, J., Guddat, L. W., Keough, D. T. and De Jersey, J. (1999). Plasmodium Falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase as a chemotherapeutic target: Comparison of the human and parasite enzymes. ComBio 99, Conrad Jupiter, Gold Coast, 27-30 September, 1999. Kent Town, SA: Australian Society for Biochemistry and Molecular Biology.

Data Collection

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genomic resources of seven Australian weed species of national significance. The University of Queensland. (Dataset) doi: 10.48610/c22c10c