Australian Infectious Diseases Research Centre

Professor Mark Walker

Professorial Research Fellow & Group Leader
Institute for Molecular Bioscience
Affiliate of Centre for Superbug Solutions
Centre for Superbug Solutions
+61 7 334 61623
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Primary research interest

Infectious diseases and vaccine development

Additional roles

Research focus and collaborations

My research focuses on the mechanism by which the group A streptococcus (Streptococcus pyogenes; GAS) causes invasive disease and GAS vaccine development. S. pyogenes is the etiologic agent of numerous suppurative diseases, ranging from mild skin infections such as pharyngitis, scarlet fever, impetigo and cellulitis, to severe invasive diseases such as septicemia, streptococcal toxic shock syndrome and necrotizing fasciitis. GAS is placed within the “top 10″ infectious disease causes of human deaths worldwide. Indigenous Australians suffer the highest rates of affliction with GAS diseases in the World. Of the over 100 M serotypes, the M1T1 clone which emerged in the mid-1980s and disseminated globally, causes most deaths and morbidity. 

Projects and patents

Funded projects

  • NHMRC Program Grant (administered by the University of Adelaide) 2015-2019 Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines. (J.C. Paton, M.P. Jennings, M. von Itzstein, M.J. Walker, B. Kobe) $8,795,785
  • NIH RO1 grant renewal 2015-2019 Defining the mechanism of group A streptococcal switching to invasive disease. (V. Nizet PI and M. Walker Co-I), US$1,833,750
  • NCRIS/Bioplatforms Australia core funding 2015-2017 Broad spectrum drug targets of antibiotic resistant sepsis pathogens. M. Walker, M. Schembri, T. Stinear, J. Iredell, T. Sorrell, D. Strugnell, J. Paton and the Australian Bacterial Sepsis Consortium, $1,000,000
  • NHMRC Principal Research Fellowship 2016-2020 (M.J. Walker)

Patents

  • 1991: High level expression of unfused Bordetella pertussis filamentous haemagglutinin for production of acellular and live oral vaccines against whooping cough. D4111531 A1 German patent application filed, PCT/EP92/00814 international patent filed. Inventors: Dr. M.J. Walker, Dr. C.A. Guzman and Prof. K.N. Timmis.
  • 1991: High level expression of Bordetella pertussis pertussis holotoxin in Bvg-negative Bordetella bronchiseptica for production of acellular vaccines against whooping cough. D4113385 A1 German patent application filed, PCT/EP92/00910 international patent filed, inventors: M.J. Walker, K.N. Timmis.
  • 1992: Antigen-containing liposomes for oral immunization. D4136553 A1 German patent application filed, PCT/2729/59 international patent application filed, inventors: M.J. Walker, H. Brahmbhatt, R.M. Brownlie, D.C. White, J. Wehland, M.W. Fountain, C. Guzman and K.N. Timmis
  • 2008: Group A streptococcal pharmaceutical compositions and methods thereof. PCT/AU2008/0011236 Australian Patent (filed 22nd August 2008) Inventors: M.J. Walker, A. Henningham, J. Cole

Teaching interests

I primarily contribute to the undergraduate subject Microbes & Human Health MICR3001, giving a series of lectures on bacterial pathogenesis and vaccine development.

Achievements and awards 

Research awards and fellowships

  • 1998: Alexander Von Humboldt fellowship
  • 2005-6: Fulbright Senior Scholar fellowship (UCSD and University of Tennessee)
  • 2009: University of Wollongong Vice Chancellor's senior researcher award
  • 2013: Fellow of the American Academy for Microbiology
  • 2014: NHMRC Development Grant Achievement Award - Top Ranked Grant

Teaching awards

  • 2000: Australian College of Education (Illawarra/South Coast NSW Chapter) excellence in tertiary teaching
  • 2003: University of Wollongong Vice Chancellor's award for outstanding teaching and learning in science
  • 2003: Australian Society of Microbiology David White excellence in teaching

Featured publications

Publications by Mark Walker

Publications

Book Chapters (6)
Journal Articles (232)
Conference Papers (7)

Book Chapters

Kotloff, Karen L. and Walker, Mark J. (2023). Streptococcus Group A Vaccines. Plotkin's Vaccines, Eighth Edition. (pp. 1095-1103.e6) Elsevier. doi: 10.1016/B978-0-323-79058-1.00057-8
Rivera-Hernandez, Tania and Walker, Mark J. (2020). Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease. Group A Streptococcus: methods and protocols. (pp. 309-316) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_24
Barnett, Timothy C., Daw, Jessica N., Walker, Mark J. and Brouwer, Stephan (2020). Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement. Group A Streptococcus: methods and protocols. (pp. 59-69) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_5
Indraratna, Anuk, De Oliveira, David M. P., Hartley-Tassell, Lauren E., Day, Christopher J., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2020). Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells. Group A Streptococcus: methods and protocols. (pp. 145-151) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY USA: Springer Nature. doi: 10.1007/978-1-0716-0467-0_10
Henningham, Anna, Gillen, Christine M. and Walker, Mark J. (2013). Group A streptococcal vaccine candidates: potential for the development of a human vaccine. Host-pathogen interactions in streptococcal diseases. (pp. 207-242) edited by G. Singh Chhatwal. New York, NY, United States: Springer. doi: 10.1007/82_2012_284
Cole, J. N., Sanderson-Smith, M. L., Cork, A. J., Henningham, A., Conlan, F., Ranson, M., McArthur, J. D. and Walker, M. J. (2007). Gene expression and tagging of streptococcal proteins. Molecular Biology of Streptococci. (pp. 359-378) edited by Regine Hakenbeck and Singh Chhatwal. Norfold, United Kingdom: Horizon Bioscience.

Journal Articles

Osowicki, Joshua, Frost, Hannah R., Azzopardi, Kristy I., Whitcombe, Alana L., McGregor, Reuben, Carlton, Lauren H., Baker, Ciara, Fabri, Loraine, Pandey, Manisha, Good, Michael F., Carapetis, Jonathan R., Walker, Mark J., Smeesters, Pierre R., Licciardi, Paul V., Moreland, Nicole J., Hill, Danika L. and Steer, Andrew C. (2024). Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections. Nature Communications, 15 (1) 10506. doi: 10.1038/s41467-024-54665-5
Lai, Chien-Yu, Xie, Jia-Xun, Lai, Meng-Chih, Wu, Zhao-Yi, Lin, Jr-Shiuan, Huang, Yu-Tsung, Chi, Chia-Yu, Chiang-Ni, Chuan, Walker, Mark J. and Chang, Yung-Chi (2024). Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus. npj Vaccines, 9 (1) 46. doi: 10.1038/s41541-024-00839-7
Shaw, Phoebe K., Hayes, Andrew J., Langton, Maree, Berkhout, Angela, Grimwood, Keith, Davies, Mark R., Walker, Mark J. and Brouwer, Stephan (2024). Clinical Snapshot of Group A Streptococcal Isolates from an Australian Tertiary Hospital. Pathogens, 13 (11) 956, 956. doi: 10.3390/pathogens13110956
McEwan, Tahnee B.‐D., De Oliveira, David M. P., Stares, Emily K., Hartley‐Tassell, Lauren E., Day, Christopher J., Proctor, Emma‐Jayne, Nizet, Victor, Walker, Mark J., Jennings, Michael P., Sluyter, Ronald and Sanderson‐Smith, Martina L. (2024). M proteins of group A Streptococcus bind hyaluronic acid via arginine–arginine/serine–arginine motifs. The FASEB Journal, 38 (20) e70123, e70123. doi: 10.1096/fj.202401301r
Brouwer, Stephan, Das, Swairindhree, Hayes, Andrew J., Bertolla, Olivia M., Davies, Mark R., Walker, Mark J., Whiley, David M., Irwin, Adam D. and Tickner, Jacob A. (2024). A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes. The Journal of Infectious Diseases. doi: 10.1093/infdis/jiae437
Rivera-Hernandez, Tania, Carnathan, Diane G., Richter, Johanna, Marchant, Patrick, Cork, Amanda J., Elangovan, Gayathiri, Henningham, Anna, Cole, Jason N., Choudhury, Biswa, Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., Good, Michael F., Agarwal, Paresh, Kapoor, Neeraj, Nizet, Victor, Silvestri, Guido and Walker, Mark J. (2024). Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model. Vaccines, 12 (4) 382, 382. doi: 10.3390/vaccines12040382
Xie, Ouli, Morris, Jacqueline M., Hayes, Andrew J., Towers, Rebecca J., Jespersen, Magnus G., Lees, John A., Ben Zakour, Nouri L., Berking, Olga, Baines, Sarah L., Carter, Glen P., Tonkin-Hill, Gerry, Schrieber, Layla, McIntyre, Liam, Lacey, Jake A., James, Taylah B., Sriprakash, Kadaba S., Beatson, Scott A., Hasegawa, Tadao, Giffard, Phil, Steer, Andrew C., Batzloff, Michael R., Beall, Bernard W., Pinho, Marcos D., Ramirez, Mario, Bessen, Debra E., Dougan, Gordon, Bentley, Stephen D., Walker, Mark J., Currie, Bart J. ... Davies, Mark R. (2024). Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis. Nature Communications, 15 (1) 2286, 1-14. doi: 10.1038/s41467-024-46530-2
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nature Reviews Microbiology, 21 (7), 431-447. doi: 10.1038/s41579-023-00865-7
Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4
Langshaw, Emma L., Reynolds, Simone, Ozberk, Victoria, Dooley, Jessica, Calcutt, Ainslie, Zaman, Mehfuz, Walker, Mark J., Batzloff, Michael R., Davies, Mark R., Good, Michael F. and Pandey, Manisha (2023). Streptolysin O deficiency in Streptococcus pyogenes M1T1 covR/S mutant strain attenuates virulence in In Vitro and In Vivo infection models. mBio, 14 (1) e03488-22, e0348822. doi: 10.1128/mbio.03488-22
Frost, Hannah R., Guglielmini, Julien, Duchêne, Sebastian, Lacey, Jake A., Sanderson-Smith, Martina, Steer, Andrew C., Walker, Mark J., Botteaux, Anne, Davies, Mark R. and Smeesters, Pierre R. (2023). Promiscuous evolution of Group A Streptococcal M and M-like proteins. Microbiology, 169 (1) 001280, 1-10. doi: 10.1099/mic.0.001280
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7). Nature Reviews Microbiology, 21 (9), 619-619. doi: 10.1038/s41579-023-00939-6
Li, Gen, Walker, Mark J. and De Oliveira, David M. P. (2022). Vancomycin resistance in Enterococcus and Staphylococcus aureus. Microorganisms, 11 (1) 24, 1-51. doi: 10.3390/microorganisms11010024
Jen, Freda E-C, Edwards, Jennifer L., El-Deeb, Ibrahim M., Walker, Mark J., von Itzstein, Mark and Jennings, Michael P. (2022). Repurposing the ionophore, PBT2, for treatment of multidrug-resistant Neisseria gonorrhoeae infections. Antimicrobial Agents and Chemotherapy, 66 (9), 1-4. doi: 10.1128/aac.02318-21
Brouwer, Stephan, Jespersen, Magnus G., Ong, Cheryl-lynn Y., De Oliveira, David M. P., Keller, Bernhard, Cork, Amanda J., Djoko, Karrera Y., Davies, Mark R. and Walker, Mark J. (2022). Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion. mBio, 13 (3), e0067622. doi: 10.1128/mbio.00676-22
De Oliveira, David M. P., Keller, Bernhard, Hayes, Andrew J., Ong, Cheryl-Lynn Y., Harbison-Price, Nichaela, El-Deeb, Ibrahim M., Li, Gen, Keller, Nadia, Bohlmann, Lisa, Brouwer, Stephan, Turner, Andrew G., Cork, Amanda J., Jones, Thomas R., Paterson, David L., McEwan, Alastair G., Davies, Mark R., McDevitt, Christopher A., Itzstein, Mark von and Walker, Mark J. (2022). Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria. Antibiotics, 11 (4) 449, 449. doi: 10.3390/antibiotics11040449
De Oliveira, David M.P. and Walker, Mark J. (2022). An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii. Microbial Cell, 9 (3), 69-71. doi: 10.15698/MIC2022.03.772
Li, Gen, De Oliveira, David M.P. and Walker, Mark J. (2022). The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection. Journal of Inorganic Biochemistry, 227 111661, 111661. doi: 10.1016/j.jinorgbio.2021.111661
De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21
Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W. and McDevitt, Christopher A. (2022). Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model. Cell Reports, 38 (2) 110202, 1-18. doi: 10.1016/j.celrep.2021.110202
Hurst, Jacklyn R., Brouwer, Stephan, Walker, Mark J. and McCormick, John K. (2021). Streptococcal superantigens and the return of scarlet fever. PLOS Pathogens, 17 (12) e1010097, e1010097. doi: 10.1371/journal.ppat.1010097
Jen, Freda E. -C., El-Deeb, Ibrahim M., Zalucki, Yaramah M., Edwards, Jennifer L., Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2021). A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides. Journal of Antimicrobial Chemotherapy, 76 (11), 2850-2853. doi: 10.1093/jac/dkab291
Richter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499
Richter, Johanna, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease. Cellular Microbiology, 23 (9) e13373, 1-9. doi: 10.1111/cmi.13373
Osowicki, Joshua, Azzopardi, Kristy I, Fabri, Loraine, Frost, Hannah R, Rivera-Hernandez, Tania, Neeland, Melanie R, Whitcombe, Alana L, Grobler, Anneke, Gutman, Sarah J, Baker, Ciara, Wong, Janet M F, Lickliter, Jason D, Waddington, Claire S, Pandey, Manisha, Schuster, Tibor, Cheng, Allen C, Pollard, Andrew J, McCarthy, James S, Good, Michael F, Dale, James B, Batzloff, Michael, Moreland, Nicole J, Walker, Mark J, Carapetis, Jonathan R, Smeesters, Pierre R and Steer, Andrew C (2021). A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study. The Lancet Microbe, 2 (7), e291-e299. doi: 10.1016/S2666-5247(20)30240-8
Loh, Jacelyn M. S., Rivera-Hernandez, Tania, McGregor, Reuben, Khemlani, Adrina Hema J., Tay, Mei Lin, Cork, Amanda J., M. Raynes, Jeremy, Moreland, Nicole J., Walker, Mark J. and Proft, Thomas (2021). A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Reports, 11 (1) 4353, 1-10. doi: 10.1038/s41598-021-83673-4
Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280
Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M. P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nature Communications, 11 (1) 5018, 5018. doi: 10.1038/s41467-020-18700-5
Stewart, Louisa J., Ong, Cheryl-Lynn Y., Zhang, May M., Brouwer, Stephan, McIntyre, Liam, Davies, Mark R., Walker, Mark J., McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2020). Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio, 11 (6) e02804-20, 1-19. doi: 10.1128/mBio.02804-20
De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791
Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2020). Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19). mBio, 11 (6) e02995-20, 1-1. doi: 10.1128/mBio.02995-20
De Oliveira, David M. P., Forde, Brian M., Kidd, Timothy J., Harris, Patrick N. A., Schembri, Mark A., Beatson, Scott A., Paterson, David L. and Walker, Mark J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical Microbiology Reviews, 33 (3) e00181-19, e00181-19. doi: 10.1128/cmr.00181-19
Dale, James B. and Walker, Mark J. (2020). Update on group A streptococcal vaccine development. Current Opinion in Infectious Diseases, 33 (3), 244-250. doi: 10.1097/QCO.0000000000000644
Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926
Harbison-Price, Nichaela, Ferguson, Scott A., Heikal, Adam, Taiaroa, George, Hards, Kiel, Nakatani, Yoshio, Rennison, David, Brimble, Margaret A., El-Deeb, Ibrahim M., Bohlmann, Lisa, McDevitt, Christopher A., von Itzstein, Mark, Walker, Mark J. and Cook, Gregory M. (2020). Multiple bactericidal mechanisms of the zinc ionophore PBT2. mSphere, 5 (2) e00157-20. doi: 10.1128/msphere.00157-20
Rivera-Hernandez, Tania, Rhyme, Mira Syahira, Cork, Amanda J., Jones, Scott, Segui-Perez, Celia, Brunner, Livia, Richter, Johanna, Petrovsky, Nikolai, Lawrenz, Maria, Goldblatt, David, Collin, Nicolas and Walker, Mark J. (2020). Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies. mBio, 11 (2) e00122-20. doi: 10.1128/mbio.00122-20
Frost, H. R., Davies, M. R., Velusamy, S., Delforge, V., Erhart, A., Darboe, S., Steer, A., Walker, M. J., Beall, B., Botteaux, A. and Smeesters, P. R. (2020). Updated emm-typing protocol for Streptococcus pyogenes. Clinical Microbiology and Infection, 26 (7), 946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026
Xu, Zhenghui, Rivera-Hernandez, Tania, Chatterjee, Oishee, Walker, Mark J. and Moyle, Peter M. (2020). Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. Journal of Controlled Release, 317, 96-108. doi: 10.1016/j.jconrel.2019.11.018
Frost, Hannah R., Davies, Mark R., Delforge, Valérie, Lakhloufi, Dalila, Sanderson-Smith, Martina, Srinivasan, Velusamy, Steer, Andrew C., Walker, Mark J., Beall, Bernard, Botteaux, Anne and Smeesters, Pierre R. (2020). Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins. mSphere, 5 (1) e00806. doi: 10.1128/mSphere.00806-19
Jen, Freda E.-C., Everest-Dass, Arun V., El-Deeb, Ibrahim M., Singh, Sanjesh, Haselhorst, Thomas, Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2020). Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2. ACS Infectious Diseases, 6 (1), 50-55. doi: 10.1021/acsinfecdis.9b00307
You, Yuanhai, Qin, Ying, Walker, Mark J., Feng, Luzhao and Zhang, Jianzhong (2019). Increased incidence of scarlet fever — China, 1999−2018. China CDC Weekly, 1 (5), 63-66. doi: 10.46234/ccdcw2019.019
Ly, Diane, Donahue, Deborah, Walker, Mark J., Ploplis, Victoria A., McArthur, Jason D., Ranson, Marie, Castellino, Francis J. and Sanderson-Smith, Martina L. (2019). Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection, 21 (8-9), 412-417. doi: 10.1016/j.micinf.2019.04.004
Brouwer, Stephan, Lacey, Jake A., You, Yuanhai, Davies, Mark R. and Walker, Mark J. (2019). Scarlet fever changes its spots. Lancet Infectious Diseases, 19 (11), 1154-1155. doi: 10.1016/S1473-3099(19)30494-3
Brouwer, Stephan and Walker, Mark J. (2019). The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections. American Journal of Pathology, 189 (10), 1913-1915. doi: 10.1016/j.ajpath.2019.07.005
De Oliveira, David M. P., Everest-Dass, Arun, Hartley-Tassell, Lauren, Day, Christopher J., Indraratna, Anuk, Brouwer, Stephan, Cleary, Ailish, Kautto, Liisa, Gorman, Jody, Packer, Nicolle H., Jennings, Michael P., Walker, Mark J. and Sanderson-Smith, Martina L. (2019). Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells. FASEB Journal, 33 (10), 10808-10818. doi: 10.1096/fj.201900559R
Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (8), 1295-1295. doi: 10.1038/s41588-019-0482-z
Osowicki, Joshua, Azzopardi, Kristy I., Baker, Ciara, Waddington, Claire S., Pandey, Manisha, Schuster, Tibor, Grobler, Anneke, Cheng, Allen C., Pollard, Andrew J., McCarthy, James S., Good, Michael F., Walker, Mark J., Dale, James B., Batzloff, Michael R., Carapetis, Jonathan R., Smeesters, Pierre R. and Steer, Andrew C. (2019). Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study. Vaccine, 37 (26), 3485-3494. doi: 10.1016/j.vaccine.2019.03.059
Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (6), 1035-1043. doi: 10.1038/s41588-019-0417-8
Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2019). An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model. mBio, 10 (2) e00693-19. doi: 10.1128/mBio.00693-19
Edgar, Rebecca J., van Hensbergen, Vincent P., Ruda, Alessandro, Turner, Andrew G., Deng, Pan, Le Breton, Yoann, El-Sayed, Najib M., Belew, Ashton T., McIver, Kevin S., McEwan, Alastair G., Morris, Andrew J., Lambeau, Gérard, Walker, Mark J., Rush, Jeffrey S., Korotkov, Konstantin V., Widmalm, Göran, van Sorge, Nina M. and Korotkova, Natalia (2019). Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nature Chemical Biology, 15 (5), 463-471. doi: 10.1038/s41589-019-0251-4
Turner, Andrew G., Djoko, Karrera Y., Ong, Cheryl-Lynn Y., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2019). Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress. Biochemical Journal, 476 (3), 595-611. doi: 10.1042/BCJ20180902
Osowicki, Joshua, Azzopardi, Kristy I., McIntyre, Liam, Rivera-Hernandez, Tania, Ong, Cheryl-Lynn Y., Baker, Ciara, Gillen, Christine M., Walker, Mark J., Smeesters, Pierre R., Davies, Mark R. and Steer, Andrew C. (2019). A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?. mSphere, 4 (1) e00647-18, e00647-18. doi: 10.1128/mSphere.00647-18
Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099
Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18. doi: 10.1128/mbio.02391-18
Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18, 1-12. doi: 10.1128/mBio.02391-18
Imai, Takashi, Matsumura, Takayuki, Mayer-Lambertz, Sabine, Wells, Christine A., Ishikawa, Eri, Butcher, Suzanne K., Barnett, Timothy C., Walker, Mark J., Imamura, Akihiro, Ishida, Hideharu, Ikebe, Tadayoshi, Miyamoto, Tomofumi, Ato, Manabu, Ohga, Shouichi, Lepenies, Bernd, van Sorge, Nina M. and Yamasaki, Sho (2018). Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proceedings of the National Academy of Sciences of the United States of America, 115 (45), E10662-E10671. doi: 10.1073/pnas.1809100115
You, Yuanhai, Davies, Mark R, Walker, Mark J and Zhang, Jianzhong (2018). Hypotheses for the resurgence of scarlet fever in China. The Lancet Infectious Diseases, 18 (9), 942-943. doi: 10.1016/S1473-3099(18)30470-5
Kawasaki, Minami, Delamare-Deboutteville, Jerome, Bowater, Rachel O, Walker, Mark J., Beatson, Scott, Ben Zakour, Nouri L. and Barnes, Andrew C. (2018). Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment. Applied and Environmental Microbiology, 84 (16) e00859-18, AEM.00859-18. doi: 10.1128/aem.00859-18
Soderholm, Amelia T. and Walker, Mark J. (2018). A host proteome atlas of Streptococcus pyogenes infection. Cell Systems, 6 (5), 536-538. doi: 10.1016/j.cels.2018.05.003
Soderholm, Amelia T., Barnett, Timothy C., Korn, Othmar, Rivera-Hernandez, Tania, Seymour, Lisa M., Schulz, Benjamin L., Nizet, Victor, Wells, Christine A., Sweet, Matthew J. and Walker, Mark J. (2018). Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Frontiers in Cellular and Infection Microbiology, 8 (MAY) 160, 160. doi: 10.3389/fcimb.2018.00160
You, Yuanhai, Kou, Yongjun, Niu, Longfei, Jia, Qiong, Liu, Yahui, Davies, Mark R., Walker, Mark J., Zhu, Jiaqiang and Zhang, Jianzhong (2018). Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing. Genome Announcements, 6 (18) e00389-18, e00389-18. doi: 10.1128/genomeA.00389-18
Ong, Cheryl-Lynn Y., Berking, Olga, Walker, Mark J. and McEwan, Alastair G. (2018). The role of zinc acquisition and zinc tolerance in group A streptococcal infection. Infection and Immunity, 86 (6) e00048-18, e00048-18. doi: 10.1128/IAI.00048-18
Walker, Mark J. and Brouwer, Stephan (2018). Scarlet fever makes a comeback. The Lancet Infectious Diseases, 18 (2), 128-129. doi: 10.1016/S1473-3099(17)30694-1
You, Yuanhai, Davies, Mark R, Protani, Melinda, McIntyre, Liam, Walker, Mark J and Zhang, Jianzhong (2018). Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis. EBioMedicine, 28, 128-135. doi: 10.1016/j.ebiom.2018.01.010
Henningham, Anna, Davies, Mark R., Uchiyama, Satoshi, van Sorge, Nina M., Lund, Sean, Chen, Kelsey T., Walker, Mark J., Cole, Jason N. and Nizet, Victor (2018). Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus. mBio, 9 (1) e02294-17, 1-12. doi: 10.1128/mBio.02294-17
Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17
Soderholm, Amelia T., Barnett, Timothy C., Sweet, Matthew J. and Walker, Mark J. (2017). Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies. Journal of Leukocyte Biology, 103 (2), 193-213. doi: 10.1189/jlb.4MR0617-227RR
Frost, Hannah, Sanderson-Smith, Martina, Walker, Mark, Botteaux, Anne and Smeesters, Pierre (2017). group A streptococcal M-Like Proteins: From pathogenesis to Vaccine POTENTIAL. FEMS microbiology reviews, 42 (2), 193-204. doi: 10.1093/femsre/fux057
Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204
Rox, Katharina, Jansen, Rolf, Loof, Torsten G., Gillen, Christine M., Bernecker, Steffen, Walker, Mark J., Chhatwal, Gursharan Singh and Müller, Rolf (2017). Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection. Scientific Reports, 7 (1) 11798, 1-12. doi: 10.1038/s41598-017-11276-z
Lim, Jin Yan, Barnett, Timothy C., Bastiani, Michele, McMahon, Kerrie-Ann, Ferguson, Charles, Webb, Richard I., Parton, Robert G. and Walker, Mark J. (2017). Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells. Cellular microbiology, 19 (12) e12772, 1-16. doi: 10.1111/cmi.12772
Djoko, Karrera Y., Phan, Minh-Duy, Peters, Kate M., Walker, Mark J. , Schembri, Mark A. and McEwan, Alastair G. (2017). Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), 6818-6823. doi: 10.1073/pnas.1620232114
Turner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17
Turner, Andrew G., Ong, Cheryl-lynn Y., Walker, Mark J., Djoko, Karrera Y. and McEwan, Alastair G. (2017). Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. Advances in Microbial Physiology, 70, 123-191. doi: 10.1016/bs.ampbs.2017.01.002
De Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16
Walker, Mark J. (2016). Tribute to professor Gursharan Singh Chhatwal. Environmental Microbiology Reports, 8 (5), 553-553. doi: 10.1111/1758-2229.12460
Heath, Candice, Gillen, Christine M., Chrysanthopoulos, Panagiotis, Walker, Mark J. and Barnes, Andrew C. (2016). Streptococcus iniae cpsG alters capsular carbohydrate composition and is a cause of serotype switching in vaccinated fish. Veterinary Microbiology, 193, 116-124. doi: 10.1016/j.vetmic.2016.08.011
Brouwer, Stephan, Barnett, Timothy C., Rivera-Hernandez, Tania, Rohde, Manfred and Walker, Mark J. (2016). Streptococcus pyogenes adhesion and colonization. FEBS Letters, 590 (21), 3739-3757. doi: 10.1002/1873-3468.12254
Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16
Walker, Mark J. (2016). Meet our editorial board member. Current Drug Targets, 17 (8), 851-851. doi: 10.2174/138945011708160504105536
Carey, Alison J., Weinberg, Jason B., Dawid, Suzanne R., Venturini, Carola, Lam, Alfred K., Nizet, Victor, Caparon, Michael G., Walker, Mark J., Watson, Michael E. and Ulett, Glen C. (2016). Interleukin-17A contributes to the control of Streptococcus pyogenes colonization and inflammation of the female genital tract. Scientific Reports, 6 (1) 26836, 26836. doi: 10.1038/srep26836
Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061
Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi: 10.1080/15548627.2015.1100356
Kliosnky, D., Ernst Wolvetang and Mark J. Walker (2016). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12 (2), 443-443. doi: 10.1080/15548627.2016.1147886
Zhang, May M., Ong, Cheryl-lynn, Walker, Mark J. and McEwan, Alastair G. (2015). Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?. Pathogens and Disease, 74 (2) ARTN ftv122, ftv122. doi: 10.1093/femspd/ftv122
Barnett, Timothy C., Cole, Jason N., Rivera-Hernandez, Tania, Henningham, Anna, Paton, James C., Nizet, Victor and Walker, Mark J. (2015). Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17 (12), 1721-1741. doi: 10.1111/cmi.12531
Ben Zakour, Nouri L., Davies, Mark R., You, Yuanhai, Chen, Jonathan H. K., Forde, Brian M., Stanton-Cook, Mitchell, Yang, Ruifu, Cui, Yujun, Barnett, Timothy C., Venturini, Carola, Ong, Cheryl-lynn Y., Tse, Herman, Dougan, Gordon, Zhang, Jianzhong, Yuen, Kwok-Yung, Beatson, Scott A. and Walker MJ (2015). Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone. Scientific Reports, 5 (1) 15877, 15877.1-15877.7. doi: 10.1038/srep15877
Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11).
Tsatsaronis, James A., Ly, Diane, Pupovac, Aleta, Goldmann, Oliver, Rohde, Manfred, Taylor, Jude M., Walker, Mark J., Medina, Eva and Sanderson-Smith, Martina L. (2015). Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses. Journal of Innate Immunity, 7 (6), 612-622. doi: 10.1159/000430498
Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002
Djoko, Karrera Y, Ong, Cheryl-lynn Y, Walker, Mark J and McEwan, Alastair G (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.. Journal of Biological Chemistry, 290 (31), 18954-18961. doi: 10.1074/jbc.R115.647099
You, Yuanhai, Wang, Haibin, Bi, Zhenwang, Walker, Mark, Peng, Xianhui, Hu, Bin, Zhou, Haijian, Song, Yanyan, Tao, Xiaoxia, Kou, Zengqiang, Meng, Fanliang, Zhang, Menghan, Bi, Zhenqiang, Luo, Fengji and Zhang, Jianzhong (2015). Molecular typing of Chinese Streptococcus pyogenes isolates. Molecular and Cellular Probes, 29 (3), 172-176. doi: 10.1016/j.mcp.2015.03.009
Ong, Cheryl-lynnY., Walker, Mark J. and McEwan, Alastair G. (2015). Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.. Scientific Reports, 5 (Art No.: 10799) 10799, 10799. doi: 10.1038/srep10799.
Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764
Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15
Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-José, Descorps-Declere, Stéphane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., Holden, Matthew T G., Poyart, Claire and Glaser, Philippe (2015). Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 6 (1) 6108. doi: 10.1038/ncomms7108
Davies, Mark R., Holden, Matthew T., Coupland, Paul, Chen, Jonathan H. K., Venturini, Carola, Barnett, Timothy C., Ben Zakour, Nouri L., Tse, Herman, Dougan, Gordon, Yuen, Kwok-Yung and Walker, Mark J. (2015). Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance. Nature Genetics, 47 (1), 84-87+. doi: 10.1038/ng.3147
Bartley, Paul B., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Muguli, Raghuram, Prado, Luis, Garnys, Vyt, Taylor, Katherine, Barnett, Timothy C., Pinna, Glen, Robson, Jennifer, Paterson, David L., Walker, Mark J., Schembri, Mark A. and Beatson, Scott A. (2015). Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak. Clinical Infectious Diseases, 62 (3), 273-279. doi: 10.1093/cid/civ870
Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11)
Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.
Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo,Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N. (2014). Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus. Journal of Biological Chemistry, 289 (46), 32303-32315. doi: 10.1074/jbc.M114.602847
Shewell, Lucy K., Harvey,Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C. and Jennings, Michael P. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.. Proceedings of the National Academy of Sciences of the United State of America, 111 (49), E5312-E5320. doi: 10.1073/pnas.1412703111
Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 (8), 1325-1338. doi: 10.1093/infdis/jiu260
Beatson, Scott A. and Walker, Mark J. (2014). Tracking antibiotic resistance. Science, 345 (6203), 1454-1455. doi: 10.1126/science.1260471
Tsatsaronis, James A., Walker, Mark J. and Sanderson-Smith, Martina L. (2014). Host responses to group A Streptococcus: cell death and inflammation. PLoS Pathogens, 10 (8) e1004266, e1004266.1-e1004266.7. doi: 10.1371/journal.ppat.1004266
Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-Jose, Descorps-Declere, Stephane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., The DEVANI Consortium, Holden, Matthew T. G. ... Glaser, Philippe (2014). Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5 (1) 4544, 4544.1-4544.11. doi: 10.1038/ncomms5544
Woolley, Lauren K., Fell, Shayne A., Gonsalves, Jocelyn R., Raymond, Benjamin B. A., Collins, Damian, Kuit, Tracey A., Walker, Mark J., Djordjevic, Steven P., Eamens, Graeme J. and Jenkins, Cheryl (2014). Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs. Vaccine, 32 (34), 4333-4341. doi: 10.1016/j.vaccine.2014.06.008
Moreland, Nicole J., Waddington, Claire S., Williamson, Deborah A., Sriskandan, Shiranee, Smeesters, Pierre R., Proft, Thomas, Steer, Andrew C., Walker, Mark J., Baker, Edward N., Baker, Michael G., Lennon, Diana, Dunbar, Rod and Fraser, John D. (2014). Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop. Vaccine, 32 (30), 3713-3720. doi: 10.1016/j.vaccine.2014.05.017
van Sorge, Nina M., Cole, Jason N., Kuipers, Kristen, Henningham, Anna, Aziz, Ramy K., Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien T. M., Davies, Mark R., Dougan, Gordon, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph A., Hutter, Julia, Lepenies, Bernd, Rooijakkers, Suzan H. M., Malley, Richard, Walker, Mark J., Shattil, Sanford J., Schlievert, Patrick M., Choudhury, Biswa and Nizet, Victor (2014). The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host and Microbe, 15 (6), 729-740. doi: 10.1016/j.chom.2014.05.009.
Ong, Cheryl-lynn Y., Gillen, Christine M., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2014). An antimicrobial role for zinc in innate immune defence against group A streptococcus. Journal of Infectious Diseases, 209 (10), 1500-1508. doi: 10.1093/infdis/jiu053
Cook, Simon M., Skora, Amanda, Walker, Mark J., Sanderson-Smith, Martina L. and McArthur, Jason D. (2014). Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants. Biochemical Journal, 458 (1), 23-31. doi: 10.1042/BJ20131305
Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754
Walker, Mark J., Barnett, Timothy C., McArthur, Jason D., Cole, Jason N., Gillen, Christine M., Henningham, Anna, Sriprakash, K. S., Sanderson-Smith, Martina L. and Nizet, Victor (2014). Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clinical Microbiology Reviews, 27 (2), 264-301. doi: 10.1128/CMR.00101-13
Barnett, Timothy C., Liebl, David, Seymour, Lisa M., Gillen, Christine M., Lim, Jin Yan, LaRock, Christopher N., Davies, Mark R., Schulz, Benjamin L., Nizet, Victor, Teasdale, Rohan D. and Walker, Mark J. (2013). The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication. Cell Host and Microbe, 14 (6), 675-682. doi: 10.1016/j.chom.2013.11.003
Venturini, Carola, Hassan, Karl A., Chowdhury, Piklu Roy, Paulsen, Ian T., Walker, Mark J. and Djordjevic, Steven P. (2013). Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts. PLoS ONE, 8 (11) e78862, e78862.1-e78862.14. doi: 10.1371/journal.pone.0078862
Towers, Rebecca J., Carapetis, Jonathan R., Currie, Bart J., Davies, Mark R., Walker, Mark J., Dougan, Gordon and Giffard, Philip M. (2013). Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification. PLoS One, 8 (9) e73851, e73851.1-e73851.6. doi: 10.1371/journal.pone.0073851
Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13
Nethercott, Cara, Mabbett, Amanda N., Totsika, Makrina, Peters, Paul, Ortiz, Juan C., Nimmo, Graeme R., Coombs, Geoffrey W., Walker, Mark J. and Schembri, Mark A. (2013). Molecular characterization of endocarditis-associated Staphylococcus aureus. Journal of Clinical Microbiology, 51 (7), 2131-2138. doi: 10.1128/JCM.00651-13
Sanderson-Smith, Martina L., Zhang, Yueling, Ly, Diane, Donahue, Deborah, Hollands, Andrew, Nizet, Victor, Ranson, Marie, Ploplis, Victoria A., Walker, Mark J. and Castellino, Francis J. (2013). A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection. PLoS Pathogens, 9 (7) e1003469, e1003469.1-e1003469.9. doi: 10.1371/journal.ppat.1003469
Venturini, Carola, Ong, Cheryl-Iynn Y., Gillen, Christine M., Ben-Zakour, Nouri L., Maamary, Peter G., Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2013). Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370. Infection and Immunity, 81 (6), 2062-2069. doi: 10.1128/IAI.00192-13
Ong, Cheryl-lynn Y., Potter, Adam J., Trappetti, Claudia, Walker, Mark J., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infection and Immunity, 81 (2), 421-429. doi: 10.1128/IAI.00805-12
Tsatsaronis, James A., Hollands, Andrew, Cole, Jason N., Maamary, Peter G., Gillen, Christine M., Ben Zakour, Nouri L., Kotb, Malak, Nizet, Victor, Beatson, Scott A., Mark J. Walker and Sanderson-Smith, Martina L. (2013). Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus. FASEB Journal, 27 (7), 2633-2643. doi: 10.1096/fj.12-226662
Woolley, Lauren K., Fell, Shayne, Gonsalves, Jocelyn R., Walker, Mark J., Djordjevic, Steven P., Jenkins, Cheryl and Eamens, Graeme J. (2012). Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates. Veterinary Microbiology, 161 (1-2), 186-195. doi: 10.1016/j.vetmic.2012.07.025
Cook, Simon M., Skora, Amanda, Gillen, Christine M., Walker, Mark J. and McArthur, Jason D. (2012). Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis. Molecular Microbiology, 86 (5), 1052-1062. doi: 10.1111/mmi.12037
Walker, Mark J. and Beatson, Scott A. (2012). Outsmarting outbreaks. Science, 338 (6111), 1161-1162. doi: 10.1126/science.1232327
Maamary, Peter G., Ben Zakour, Nouri L., Cole, Jason N., Hollands, Andrew, Aziz, Ramy K., Barnett, Timothy C., Cork, Amanda J., Henningham, Anna, Sanderson-Smith, Martina, McArthur, Jason D., Venturini, Carola, Gillen, Christine M., Kirk, Joshua K., Johnson, Dwight R., Taylor, William L., Kaplan, Edward L., Kotb, Malak, Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2012). Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB Journal, 26 (11), 4675-4684. doi: 10.1096/fj.12-212142
Tse, Herman, Bao, Jessie Y. J., Davies, Mark R., Maamary, Peter, Tsoi, Hoi-Wah, Tong, Amy H. Y., Ho, Tom C. C., Lin, Chi-Ho, Gillen, Christine M., Barnett, Timothy C., Chen, Jonathan H. K., Lee, Mianne, Yam, Wing-Cheong, Wong, Chi-Kin, Ong, Cheryl-lynn Y., Chan, Yee-Wai, Wu, Cheng-Wei, Ng, Tony, Lim, Wilina W. L., Tsang, Thomas H. F., Tse, Cindy W. S., Dougan, Gordon, Walker, Mark J., Lok, Si and Yuen, Kwok-Yung (2012). Molecular characterization of the 2011 Hong Kong scarlet fever outbreak. The Journal of Infectious Diseases, 206 (3), 341-351. doi: 10.1093/infdis/jis362
Henningham, Anna, Barnett, Timothy C., Maamary, Peter G. and Walker, Mark J. (2012). Pathogenesis of group A streptococcal infections. Discovery Medicine, 13 (72), 329-342.
Bogema, Daniel R., Deutscher, Ania T., Woolley, Lauren K., Seymour, Lisa M., Raymond, Benjamin B. A., Tacchi, Jessica L., Padula, Matthew P., Dixon, Nicholas E., Minion, F. Chris, Jenkins, Cheryl, Walker, Mark J. and Djordjevic, Steven P. (2012). Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography. mBio, 3 (2) e00282-11, e00282.1-e00282.11. doi: 10.1128/mBio.00282-11
Dawes, Fay E., Bulach, Dieter M., Kuzevski, Alexander, Bettelheim, Karl A., Venturini, Carola, Djordjevic, Steven P. and Walker, Mark J. (2012). Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an alpha-Hemolytic Escherichia coli O108:H- Human Clinical Isolate. Plos One, 7 (4) e34718, e34718.1-e34718.6. doi: 10.1371/journal.pone.0034718
Amin, Khairul Anuar Mat, Gilmore, Kerry J., Matic, Jake, Poon, Stephen, Walker, Mark J., Wilson, Mark R. and Panhuis, Marc In Het (2012). Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers. Macromolecular Bioscience, 12 (3), 374-382. doi: 10.1002/mabi.201100317
McArthur, Jason D., Cook, Simon M., Venturini, Carola and Walker, Mark J. (2012). The role of streptokinase as a virulence determinant of Streptococcus pyogenes: Potential for therapeutic targeting. Current Drug Targets, 13 (3), 297-307. doi: 10.2174/138945012799424589
Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012). Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 (10), 1197-1207. doi: 10.1007/s00109-012-0897-9
Walker, Mark (2012). Establishment of the Australian Infectious Diseases Research Centre. Current Drug Targets, 13 (11), 1347-1347. doi: 10.2174/138945012803530189
Ben Zakour, Nouri L., Venturini, Carola, Beatson, Scott A. and Walker, Mark J. (2012). Analysis of a Streptococcus pyogenes puerperal sepsis cluster using whole-genome sequencing. Journal of Clinical Microbiology, 50 (7), 2224-2228. doi: 10.1128/JCM.00675-12
Seymour, Lisa M., Jenkins, Cheryl, Deutscher, Ania T., Raymond, Benjamin B. A., Padula, Matthew P., Tacchi, Jessica L., Bogema, Daniel R., Eamens, Graeme J., Woolley, Lauren K., Dixon, Nicholas E., Walker , Mark J. and Djordjevic, Steven P. (2012). Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface. Cellular Microbiology, 14 (1), 81-94. doi: 10.1111/j.1462-5822.2011.01702.x
Bogema, Daniel R., Scott, Nichollas E., Padula, Matthew P., Tacchi, Jessica L., Raymond, Benjamin B. A., Jenkins, Cheryl, Cordwell, Stuart J., Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2011). Sequence TTKF (down arrow) QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae. Journal of Biological Chemistry, 286 (48), 41217-41229. doi: 10.1074/jbc.M111.226084
Cole, Jason N., Barnett, Timothy C., Nizet, Victor and Walker, Mark J. (2011). Molecular insight into invasive group A streptococcal disease. Nature Reviews Microbiology, 9 (10), 724-736. doi: 10.1038/nrmicro2648
Seymour, Lisa M., Falconer, Linda, Deutscher, Ania T., Minion, F. Chris, Padula, Matthew P., Nicholas E. Dixon,, Djordjevic, Steven P. and Walker, Mark J. (2011). Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae. Journal of Biological Chemistry, 286 (12), 10097-10104. doi: 10.1074/jbc.M110.208140
Treweek, TM, Rekas, A, Walker, MJ and Carver, JA (2010). A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin. Experimental Eye Research, 91 (5), 691-699. doi: 10.1016/j.exer.2010.08.015
Seymour, Lisa M., Deutscher, Ania T., Jenkins, Cheryl, Kuit, Tracey A., Falconer, Linda, Minion, F. Chris, Crossett, Ben, Padula, Matthew, Dixon, Nicholas E., Djordjevic, Steven P. and Walker, Mark J. (2010). A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia. Journal of Biological Chemistry, 285 (44), 33971-33978. doi: 10.1074/jbc.M110.104463
Deutscher, Ania T., Jenkins, Cheryl, Minion, F. Chris, Seymour, Lisa M., Padula, Matthew P., Dixon, Nicholas E., Walker, Mark J. and Djordjevic, Steven P. (2010). Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia. Molecular Microbiology, 78 (2), 444-458. doi: 10.1111/j.1365-2958.2010.07345.x
Maamary, PG, Sanderson-Smith, ML, Aziz, RK, Hollands, A, Cole, JN, Mckay, FC, McArthur, JD, Kirk, JK, Cork, AJ, Keefe, RJ, Kansal, RG, Sun, H, Taylor, WL, Chhatwal, GS, Ginsburg, D, Nizet, V, Kotb, M and Walker, MJ (2010). Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. Journal of Innate Immunology, 2 (6), 596-606. doi: 10.1159/000317640
Dawes, Faye E., Kuzevski, Alexander, Bettelheim, Karl A., Hornitzky, Michael A., Djordjevic, Steven P. and Walker, Mark J. (2010). Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin. PLoS One, 5 (9) e12754, e12754-1-e12754-6. doi: 10.1371/journal.pone.0012754
Cole, JN, Pence, MA, von Kockritz-Blickwede, M, Hollands, A, Gallo, RL, Walker, MJ and Nizet, V (2010). M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus. mBio, 1 (4) e00191-10, e00191-10-1-e00191-10-8. doi: 10.1128/mBio.00191-10
Hollands, Andrew, Pence, Morgan A., Timmer, Anjuli M., Osvath, Sarah R., Turnbull, Lynne, Whitchurch, Cynthia B., Walker, Mark J. and Nizet, Victor (2010). Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone. Journal of Infectious Diseases, 202 (1), 11-19. doi: 10.1086/653124
Figuera-Losada, M., Ranson, M., Sanderson-Smith, M.L., Walker, M. J., Castellino, F. J. and Prorok, M. (2010). Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). BBA - Proteins and Proteomics, 1804 (6), 1342-1349. doi: 10.1016/j.bbapap.2010.01.019
Aziz, Ramy K., Kansal, Rita, Aronow, Bruce J., Taylor, William L., Rowe, Sarah L., Kubal, Michael, Chhatwal, Gursharan S., Walker, Mark J. and Kotb, Malak (2010). Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence. PLoS One, 5 (4) e9798, e9798. doi: 10.1371/journal.pone.0009798
Venturini, C, Beatson, SA, Djordjevic, SP and Walker, MJ (2010). Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid. The FASEB Journal, 24 (4), 1160-1166. doi: 10.1096/fj.09-144972
Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317
Matic, Jake N., Terry, Tamsin D., Van Bockel, David, Maddocks, Tracy, Tinworth, David, Jennings, Michael P., Djordjevic, Steven P. and Walker, Mark J. (2009). Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium. Infection and Immunity, 77 (5), 1817-1826. doi: 10.1128/IAI.01301-08
Wilton, Jody, Jenkins, Cheryl, Cordwell, Stuart J., Falconer, Linda, Minion, F. Chris, Oneal, David C., Djordjevic, Michael A., Connolly, Angela, Barchia, Idris, Walker, Mark J. and Djordjevic, Steven P. (2009). Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Molecular Microbiology, 71 (3), 566-582. doi: 10.1111/j.1365-2958.2008.06546.x
Hollands, Andrew, Aziz, Ramy K., Kansal, Rita, Kotb, Malak, Nizet, Victor and Walker, Mark J. (2008). A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One, 3 (12 Article # e4102) e4102, e4102. doi: 10.1371/journal.pone.0004102
Morris, Amie M., Treweek, Teresa M., Aquilina, J. A., Carver, John A. and Walker, Mark J. (2008). Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity. FEBS Journal, 275 (23), 5885-5898. doi: 10.1111/j.1742-4658.2008.06719.x
McArthur, Jason D., McKay, Fiona C., Ramachandran, Vidiya, Shyam, Priya, Cork, Amanda J., Sanderson-Smith, Martina L., Cole, Jason N., Ringdahl, Ulrika, Sjobring, Ulf, Ranson, Marie and Walker, Mark J. (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. Faseb Journal, 22 (9), 3146-3153. doi: 10.1096/fj.08-109348
Sanderson-Smith, M. L., Dinkla, K., Cole, J. N., Cork, A. J., Maamary, P. G., McArthur, J. D., Chhatwal, G. S. and Walker, M. J. (2008). M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. The FASEB Journal, 22 (8), 2715-2722. doi: 10.1096/fj.07-105643
Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008). Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 (3), 387-410. doi: 10.1002/prca.200780048
Gillen, Christine M., Courtney, Harry S., Schulze, Kai, Rohde, Manfred, Wilson, Mark R., Timmer, Anjulli M., Guzman, Carlos A., Nizet, Victor, Chhatwal, G. s. and Walker, Mark J. (2008). Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. Journal of Biological Chemistry, 283 (10), 6359-6366. doi: 10.1074/jbc.M706739200
Cole, Jason N, Djordjevic, Steven P and Walker, Mark J (2008). Isolation and solubilization of gram-positive bacterial cell wall-associated proteins. Methods in molecular biology (Clifton, N.J.), 425, 295-311.
Cole, Jason N., Aquilina, John A., Hains, Peter G., Henningham, Anna, Sriprakash, Kadaba S., Caparon, Michael G., Nizet, Victor, Kotb, Malak, Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2007). Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics, 7 (24), 4488-4498. doi: 10.1002/pmic.200700626
Treweek, Teresa M., Ecroyd, Heath, Williams, Danielle M., Meehan, Sarah, Carver, John A. and Walker, Mark J. (2007). Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation. PLoS One, 2 (Article # e1046) e1046, e1046. doi: 10.1371/journal.pone.0001046
Walker, Mark J., Hollands, Andrew, Sanderson-Smith, Martina L., Cole, Jason N., Kirk, Joshua K., Henningham, Anna, McArthur, Jason D., Dinkla, Katrin, Aziz, Ramy K., Kansal, Rita G., Simpson, Amelia J., Buchanan, John T., Chhatwal, Gursharan S., Kotb, Malak and Nizet, Malak (2007). DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nature Medicine, 13 (8), 981-985. doi: 10.1038/nm1612
Tart, Anne H., Walker, Mark J. and Musser, James M. (2007). New understanding of the group A Streptococcus pathogenesis cycle. Trends in Microbiology, 15 (7), 318-325. doi: 10.1016/j.tim.2007.05.001
Wu, X. -Y., Walker, M., Vanselow, B., Chao, R. -L. and Chin, J. (2007). Characterization of mesophilic bacilli in faeces of feedlot cattle. Journal of Applied Microbiology, 102 (3), 872-879. doi: 10.1111/j.1365-2672.2006.03106.x
Wu, Xi-Yang, Chapman, Toni, Trott, Darren J., Bettelheim, Karl, Do, Thuy N., Driesen, Steve, Walker, Mark J. and Chin, James (2007). Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs. Applied and Environmental Microbiology, 73 (1), 83-91. doi: 10.1128/AEM.00990-06
Timmer, Anjuli M., Kristian, Sascha A., Datta, Vivekanand, Jeng, Arthur, Gillen, Christine M., Walker, Mark J., Beall, Bernard and Nizet, Victor (2006). Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Molecular Microbiology, 62 (1), 15-25. doi: 10.1111/j.1365-2958.2006.05337.x
Sanderson-Smith, Martina L., Walker, Mark J. and Ranson, Marie (2006). The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains. Journal of Biological Chemistry, 281 (36), 25965-25971. doi: 10.1074/jbc.M603846200
Cole, Jason N., McArthur, Jason D., McKay, Fiona C., Sanderson-Smith, Martina L., Cork, Amanda J., Ranson, Marie, Rohde, Manfred, Itzek, Andreas, Sun, Hongmin, Ginsburg, David, Kotb, Malak, Nizet, Victor, Chhatwal, GS and Walker, Mark J. (2006). Trigger for group A streptococcal M1T1 invasive disease. FASEB Journal, 20 (10), E1139-E1145. doi: 10.1096/fj.06-5804fje
Poljak, Anne, Grant, Ross, Austin, Chris J. D., Jamie, Joanne F., Willows, Robert D., Takikawa, Osamu, Littlejohn, Tamantha K., Truscott, Roger J. W., Walker, Mark J., Sachdev, Perminder and Smythe, George A. (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450 (1), 9-19. doi: 10.1016/j.abb.2006.03.003
Burnett, Tracey A., Dinkla, Katrin, Rohde, Manfred, Chhatwal, Gursharan S., Uphoff, Cord, Srivastava, Mukesh, Cordwell, Stuart J., Geary, Steven, Liao, Xiaofen, Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2006). P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells. Molecular Microbiology, 60 (3), 669-686. doi: 10.1111/j.1365-2958.2006.05139.x
Sanderson-Smith, Martina, Batzloff, Michael, Sriprakash, Kabada S., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2006). Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants. Journal of Biological Chemistry, 281 (6), 3217-3226. doi: 10.1074/jbc.M508758200
Jenkins, Cheryl, Wilton, Jody L., Minion, F. Chris, Falconer, Linda, Walker, Mark J. and Djordjevic, Steven P. (2006). Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin. Infection and Immunity, 74 (1), 481-487. doi: 10.1128/IAI.74.1.481-487.2006
McArthur, Jason D. and Walker, Mark J. (2006). Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development. Molecular Microbiology, 59 (1), 1-4. doi: 10.1111/j.1365-2958.2005.04967.x
Wu, Xi-Yang, Walker, Mark J., Hornitzky, Michael and Chin, James (2006). Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance. Journal of Microbiological Methods, 64 (1), 107-119. doi: 10.1016/j.mimet.2005.04.021
Walker, Mark J., McArthur, Jason D., McKay, Fiona and Ranson, Marie (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor?. Trends in Microbiology, 13 (7), 308-313. doi: 10.1016/j.tim.2005.05.006
Cole, Jason N., Ramirez, Ruben D., Currie, Bart J., Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2005). Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus. Infection and Immunity, 73 (5), 3137-3146. doi: 10.1128/IAI.73.5.3137-3146.2005
Treweek, Teresa M., Rekas, Agata, Lindner, Robyn A., Walker, Mark J., Aquilina, J. Andrew, Robinson, Carol V., Horwitz, Joseph, Perng, Ming Der, Quinlan, Roy A. and Carver, John A. (2005). R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable. FEBS Journal, 272 (3), 711-724. doi: 10.1111/j.1742-4658.2004.04507.x
McArthur, J., Medina, E., Mueller, A., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S. and Walker, M. J. (2004). Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model. Infection and Immunity, 72 (12), 7342-7345. doi: 10.1128/IAI.72.12.7342-7345.2004
Towers, Rebecca J., Gal, Daniel, McMillan, David, Sriprakash, Kadaba S., Currie, Bart J., Walker, Mark J., Chhatwal, Gursharan S. and Fagan, Peter K. (2004). Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci. Journal of Clinical Microbiology, 42 (11), 5357-5361. doi: 10.1128/JCM.42.11.5357-5361.2004
Ramachandran, V., McArthur, J. D., Behm, C. E., Gutzeit, C., Dowton, M., Fagan, P. K., Towers, R., Currie, B., Sriprakash, K. S. and Walker, M. J. (2004). Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes. Journal of Bacteriology, 186 (22), 7601-7609. doi: 10.1128/JB.186.22.7601-7609.2004
McArthur, J., Schulze, K., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S., Guzmán, C. A. and Walker, M. J. (2004). Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice. Indian Journal of Medical Research, Supplement, 119 (MAY), 115-120.
McKay, Fiona C., McArthur, Jason D., Sanderson-Smith, Marina L., Gardam, Sandra, Currie, Bart J., Sriprakash, Kadaba S., Fagan, Peter K., Towers, Rebecca J., Batzloff, Michael R., Chhatwal, Gursharan S., Ranson, Marie and Walker, Mark J. (2004). Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity, 72 (1), 364-370. doi: 10.1128/IAI.72.1.364-370.2004
Towers, R. J., Fagan, P. K., Talay, S. R., Currie, B. J., Sriprakash, K. S., Walker, M. J. and Chhatwal, G. S. (2003). Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure. Journal of Clinical Microbiology, 41 (12), 5398-5406. doi: 10.1128/JCM.41.12.5398-5406.2003
Ramachandran, V., Brett, K., Hornitzky, M. A., Dowton, M., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources. Journal of Clinical Microbiology, 41 (11), 5022-5032. doi: 10.1128/JCM.41.11.5022-5032.2003
Matic, JN, Wilton, JL, Towers, RJ, Scarman, AL, Minion, FC, Walker, MJ and Djordjevic, SP (2003). The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement. Gene, 319, 99-106. doi: 10.1016/S0378-1119(03)000798-4
Littlejohn, TK, Takikawa, O, Truscott, RJW and Walker, MJ (2003). Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. Journal of Biological Chemistry, 278 (32), 29525-29531. doi: 10.1074/jbc.M301700200
Brett, K. N., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes. Journal of Clinical Microbiology, 41 (6), 2716-2722. doi: 10.1128/JCM.41.6.2716-2722.2003
McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9
Brett, K. N., Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle. Journal of Clinical Microbiology, 41 (3), 926-936. doi: 10.1128/JCM.41.3.926-936.2003
Littlejohn, Tamantha K., Takikawa, Osamu, Jamie, Joanne F., Walker, Mark J. and Truscott, Roger J.W (2002). Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis. International Congress Series, 1233 (C), 157-160. doi: 10.1016/S0531-5131(02)00312-6
Erdogan, Sezgin, Fagan, Peter K., Talay, Susanne R., Rohde, Manfred, Ferrieri, Patricia, Flores, Aurea E., Guzman, Carlos A., Walker, Mark J. and Chhatwal, Gursharan S. (2002). Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci. Infection and Immunity, 70 (2), 803-811. doi: 10.1128/IAI.70.2.803-811.2002
Gillen, Christine M., Towers, Rebecca J., McMillan, David J., Delvecchio, Armando, Sriprakash, Kadaba S., Currie, Bart, Kreikemeyer, Berndt, Chhatwal, Gurusharan S. and Walker, Mark J. (2002). Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor. Microbiology, 148 (1), 169-178. doi: 10.1099/00221287-148-1-169
Delvecchio, A., Currie, B. J., McArthur, J. D., Walker, M. J. and Sriprakash, K. S. (2002). Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia. Epidemiology and Infection, 128 (3), 391-396. doi: 10.1017/S0950268802006787
Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2001). The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. Journal of Clinical Microbiology, 39 (5), 1932-1937. doi: 10.1128/JCM.39.5.1932-1937.2001
Smith, AM, Guzman, CA and Walker, MJ (2001). The virulence factors of Bordetella pertussis: a matter of control. Fems Microbiology Reviews, 25 (3), 309-333. doi: 10.1111/j.1574-6976.2001.tb00580.x
Fagan, PK, Walker, MJ, Chin, J, Eamens, GJ and Djordjevic, SP (2001). Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs. Microbial Pathogenesis, 30 (2), 101-110. doi: 10.1006/mpat.2000.0412
Smith, AM, Yan, H, Groves, N, Dalla Pozza, T and Walker, MJ (2000). Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli. Fems Microbiology Letters, 191 (2), 177-182. doi: 10.1016/S0378-1097(00)00386-4
West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A. and Walker, Mark J. (2000). Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infection and Immunity, 68 (8), 4673-4680. doi: 10.1128/IAI.68.8.4673-4680.2000
Littlejohn, TK, Takikawa, O, Skylas, D, Jamie, JF, Walker, MJ and Truscott, RJW (2000). Expression and purification of recombinant human indoleamine 2,3-dioxygenase. Protein Expression and Purification, 19 (1), 22-29. doi: 10.1006/prep.2000.1214
McMillan, DJ, Medina, E, Guzman, CA and Walker, MJ (1999). Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract. Fems Microbiology Letters, 178 (1), 7-11. doi: 10.1111/j.1574-6968.1999.tb13752.x
San Gil, F, Turner, B, Walker, MJ, Djordjevic, SP and Chin, JC (1999). Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae. Microbiology-Uk, 145 (9), 2595-2603. doi: 10.1099/00221287-145-9-2595
Jungnitz, Heidrun, West, Nicholas P., Walker, Mark J., Chhatwal, Gursharan S. and Guzman, Carlos A. (1998). A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence. Infection and Immunity, 66 (10), 4640-4650.
Djordjevic, SP, Eamens, GJ, Ha, H, Walker, MJ and Chin, JC (1998). Demonstration that Australian Pasteurella multocida isolates from sporadic outbreaks of porcine pneumonia are non-toxigenic (toxA(-)) and display heterogeneous DNA restriction endonuclease profiles compared with toxigenic isolates from herds with progress. Journal of Medical Microbiology, 47 (8), 679-688. doi: 10.1099/00222615-47-8-679
Wilton, JL, Scarman, AL, Walker, MJ and Djordjevic, SP (1998). Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae. Microbiology-Uk, 144 (7), 1931-1943. doi: 10.1099/00221287-144-7-1931
Wilton, Jody L., Scarman, Anthony L., Walker, Mark J. and Djordjevic, Steven P. (1998). Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae. Microbiology, 144 (7), 1931-1942.
Dalla Pozza, T, Yan, HR, Meek, D, Guzman, CA and Walker, MJ (1998). Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits. Vaccine, 16 (5), 522-529. doi: 10.1016/S0264-410X(97)80006-0
San Gil, F, Turner, B, Mullbacher, A, Walker, MJ, Djordjevic, SP, Eamens, GJ and Chin, JC (1998). Flow cytometric analysis of cellular changes in mice after intradermal inoculation with a liposome-iscom adjuvanted vaccine. Scandinavian Journal of Immunology, 47 (3), 243-253. doi: 10.1046/j.1365-3083.1998.00304.x
McMillan, DJ, Mau, M and Walker, MJ (1998). Characterisation of the urease gene cluster in Bordetella bronchiseptica. Gene, 208 (2), 243-251. doi: 10.1016/S0378-1119(97)00651-3
Fagan, Peter K., Djordjevic, Steve P., Chin, James, Eamens, Graeme J. and Walker, Mark J. (1997). Oral immunization of mice with attenuated Salmonella typhimurium aroA expressing a recombinant Mycoplasma hyopneumoniae antigen (NrdF). Infection and Immunity, 65 (6), 2502-2507.
Pozza, TD, Yan, HR and Walker, MJ (1997). Expression of a synthetic pertussis toxin operon in Escherichia coli. Vaccine, 15 (9), 968-975. doi: 10.1016/S0264-410X(96)00306-4
Chhatwal, GS, Walker, MJ, Yan, HR, Timmis, KN and Guzman, CA (1997). Temperature dependent expression of an acid phosphatase by Bordetella bronchiseptica: Role in intracellular survival. Microbial Pathogenesis, 22 (5), 257-264. doi: 10.1006/mpat.1996.0118
West, NP, Fitter, JT, Jakubzik, U, Rodhe, M, Guzman, CA and Walker, MJ (1997). Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells. Fems Microbiology Letters, 146 (2), 263-269. doi: 10.1111/j.1574-6968.1997.tb10203.x
McMillan, DJ, Shojaei, M, Chhatwal, GS, Guzman, CA and Walker, MJ (1996). Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica. Microbial Pathogenesis, 21 (5), 379-394. doi: 10.1006/mpat.1996.0069
Partridge, Sally R., Baker, Mark S., Walker, Mark J. and Wilson, Mark R. (1996). Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates. Infection and Immunity, 64 (10), 4324-4329.
Smith, AM and Walker, MJ (1996). Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique. Microbial Pathogenesis, 20 (5), 263-273. doi: 10.1006/mpat.1996.0025
Fagan, Peter K., Djordjevic, Steven P., Eamens, Graeme J., Chin, James and Walker, Mark J. (1996). Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia. Infection and Immunity, 64 (3), 1060-1064.
Southan, MD, Truscott, RJW, Jamie, JF, Pelosi, L, Walker, MJ, Maeda, H, Iwamoto, Y and Tone, S (1996). Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase. Medicinal Chemistry Research, 6 (5), 343-352.
Guzman, CA, Piatti, G, Walker, MJ, Guardati, MC and Pruzzo, C (1994). A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System. Gene, 148 (1), 171-172. doi: 10.1016/0378-1119(94)90254-2
Gohmann, S, Manning, PA, Alpert, CA, Walker, MJ and Timmis, KN (1994). Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant. Microbial Pathogenesis, 16 (1), 53-64. doi: 10.1006/mpat.1994.1005
Guzman, Carlos A., Molinari, Gabriella, Fountain, Michael W., Rohde, Manfred, Timmis, Kenneth N. and Walker, Mark J. (1993). Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid. Infection and Immunity, 61 (2), 573-579.
Walker, Mark J., Rohde, Manfred, Timmis, Kenneth N. and Guzman, Carlos A. (1992). Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit. Infection and Immunity, 60 (10), 4260-4268.
Guzman, CA, Walker, MJ, Rohde, M and Timmis, KN (1992). Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System. Microbial Pathogenesis, 12 (5), 383-389. doi: 10.1016/0882-4010(92)90101-S
Guzman, Carlos A., Brownlie, Robert M., Kadurugamuwa, Jagath, Walker, Mark J. and Timmis, Kenneth N. (1991). Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis. Infection and Immunity, 59 (12), 4391-4397.
Walker, Mark J., Wehland, Jurgen, Timmis, Kenneth N., Raupach, Barbel and Schmidt, M. A. (1991). Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells. Infection and Immunity, 59 (11), 4249-4251.
Walker, Mark J., Rohde, Manfred, Wehland, Jurgen and Timmis, Kenneth N. (1991). Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica. Infection and Immunity, 59 (11), 4238-4248.
Guzman, Carlos A., Walker, Mark J., Rohde, Manfred and Timmis, Kenneth N. (1991). Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa. Infection and Immunity, 59 (10), 3787-3795.
Walker, Mark J., Guzman, Carlos A., Rohde, Manfred and Timmis, Kenneth N. (1991). Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals. Infection and Immunity, 59 (5), 1739-1746.
Walker, MJ, Rohde, M, Brownlie, RM and Timmis, KN (1990). Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures. Molecular Microbiology, 4 (1), 39-47. doi: 10.1111/j.1365-2958.1990.tb02013.x
Walker, MJ, Birch, RG and Pemberton, JM (1988). Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca. Molecular Microbiology, 2 (4), 443-454. doi: 10.1111/j.1365-2958.1988.tb00050.x
Walker, MJ and Pemberton, JM (1988). Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria. Current Microbiology, 17 (2), 69-75. doi: 10.1007/BF01568788
Walker, MJ and Pemberton, JM (1987). Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca. Archives of Microbiology, 146 (4), 390-395. doi: 10.1007/BF00410941

Conference Papers

Cole, Jason, van Sorge, Nina, Kuipers, Kirsten, Henningham, Anna, Aziz, Ramy, Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien, Davies, Mark, Dougan, Gordan, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph, Rooijakkers, Suzan, Malley, Richard, Walker, Mark, Shattil, Sanford, Schlievert, Patrick, Choudhury, Biswa and Nizet, Victor (2014). Genetics and virulence role of the classical group A Streptococcus Lancefield antigen. Experimental Biology Meeting, San Diego Ca, 26-30 April 2014. Federation of American Societies for Experimental Biology.
Deutscher, Ania T., Tacchi, Jessica L., Minion, F. Chris, Padula, Matthew P., Crossett, Ben, Bogema, Daniel R., Jenkins, Cheryl, Kuit, Tracey A., Walker, Mark J. and Djordjevic, Steven P. (2012). Mycoplasma hyopneumoniae surface proteins Mhp385 and Mhp384 bind host cilia and glycosaminoglycans and are endoproteolytically processed by proteases that recognize different cleavage motifs. Washington, DC, United States: American Chemical Society. doi: 10.1021/pr201115v
Sanderson-Smith, Martina L., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2007). The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues. Washington, DC, United States: American Society for Microbiology. doi: 10.1128/JB.01218-06
Wu, X.Y., Chapman, T., Tan, M.K., Trott, D. J., Walker, M. and Chin, J. (2003). Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE). Australasian Pig Science Assoc (Inc) Conference, Fremantle, WA, 23-26 November 2003. Fremantle, WA: Australasian Pig Science Assoc..
Wu, X. Y., Chapman, T., Gordon, D., Do, N. T., Driesen, S., Walker, M. and Chin, J. (2003). Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea. The Ninth Biennial Conference of the Australasian Pig Science Association, Fremantle, WA, 23 - 26 Nov 2003. Werribee, Victoria: Australian Pig Science Association.
Takikawa, O., Littlejohn, T., Jamie, J. F., Walker, M. J. and Truscott, R. J.W. (2000). Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract.
Guzman, CA, Timmis, KN and Walker, MJ (1993). Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route. NATO Advanced Research Workshop on Biology of Salmonella, Portorosa Italy, May 11-15, 1992. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.