Australian Infectious Diseases Research Centre

Professor Gary Schenk

Professor
School of Chemistry and Molecular Biosciences
Affiliate Professor of Australian Institute for Bioengineering and Nanotechnology
Australian Institute for Bioengineering and Nanotechnology
+61 7 336 54144
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Primary reseach interest

Physical chemistry - structure, function, mechanism and pharmaceutical potential of metalloenzymes

Additional roles

  • Group leader in protein chemistry and enzymology
  • Member of UQ's Latin American Study Group (LASG) - representative for the Faculty of Science

About me

I obtained a Diploma in Chemistry from the University of Berne in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (in 1993) to carry out research towards a PhD in Biochemistry (supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at The University of Queensland under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period I was awarded Fellowships from both the Wellcome Trust and The University of Queensland.  In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)physical Chemistry at The University of Queensland. In 2006 I was promoted to Senior Lecturer.  Following the award of a University of Queensland Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2009). Since 2011 I also hold a professorial appointment at the National University of Ireland - Maynooth (NUIM). Most recently, in 2012, I have been awarded an ARC Future Fellowship (commences in April 2013).

Research focus and collaborations

My research lies at the interface between biochemistry, and biotechnology, inorganic and physical chemistry. Methodologies applied range from protein expression, purification and characterisation, mutagenesis, steady- and pre-steady-state enzyme kinetics to various types of molecular spectroscopy. Local collaborators are Profs Luke Guddat, Ross McGeary, Lawrence Gahan, Graeme Hanson, Mark Riley, Paul Meredith.

Specifically, I am interested in the study of the reaction mechanisms of enzymes requiring metal ions for their catalytic function. In particular, my current research focuses on a group of binuclear metallohdrolases, which play crucial roles in a variety of metabolic functions, including bone and collagen resorption, prevention of oxidative damage, correction of errors in DNA replication and cell proliferation. Some of these enzymes¸the metallo-β-lactamases, are also major contributors to the growing emergence of antibiotic-resistant pathogens. My aim is to gain detailed insight into the geometric and electronic structures of these enzymes to develop and design transition state analogues and specific inhibitors of chemotherapeutic and medicinal significance.

I am also interested in enzymes that degrade organophosphate pesticides and nerve agents. These enzymes have gained increasing attention due to their great potential as bioremediators and anti-warfare agents (collaboration with Prof. David Ollis, ANU).

Studies on protein systems are complemented by studies on relevant model complexes (biomimetics; collaboration with Prof. L. Gahan, UQ). In addition to these predominantly mechanistic investigations I also engage in comparative studies to define sequence and structural fingerprints that contribute to metal ion selectivity in protein active sites, and I am interested in evolving enzymatic activities in vitro to perform desired tasks (collaboration with Prof. D. Ollis, ANU). Last but not least, I am also interested in probing the factors that contribute to functional promiscuity in enzyme-catalysed reactions, a phenomenon that has attracted increasing significance since it also harbours the potential to tune enzymes to perform particular tasks that may be beneficial to a variety of applications.

International research collaborations

  • Prof. Ademir Neves, Universidade de Santa Catarina, Florianopolis, Brazil
  • Prof. Jim Larrabee, Middlebury College, Middlebury, USA
  • Prof. Alvan Hengge, Utah State University, Logan, USA
  • Prof. Stefano Ciurli, University of Bologna, Bologna, Italy
  • Prof. Peter Comba, University of Heidelberg, Heidelberg, Germany
  • Prof. Adolfo Horn, Universidade Estadual de Norte Fluminense, Fluminense, Brazil

Funded projects

  • NHMRC Project Grant 2015-2017, An integrated approach to combat antibiotic resistance
  • NHMRC Project Grant 2010-2012, Metallo-β-lactamases: predicting and combating antibiotic resistance, Total value of grant: $512,000
  • ARC Discovery Grant 2012-2014, Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine, Total value of grant: $285,000
  • ARC Future Fellowship 2013-2017, Metals in biocatalysis, Total value of grant: $821,000

Teaching interests

Bio-physical and bio-inorganic chemistry including chemical and enzyme kinetics, thermodynamics, and chemical equilibrium, as well as bioinorganic chemistry and electron paramagnetic resonance.

Student supervision

  • PhD Students (15): S. Smith, K. Hadler, E. Leung, F. Ely, P. Vella, A. Kan, L. Daumann, S. Wong, A. Bhumkar, N. Pue, M. M. Pedroso, D. Feder, S.H. Mohd-Pahmi, O. Arjomandi, D. Tan
  • Honours (11): L. McDonald, P. Herrald, T. Elliott, P. Lee, S. Wong, R. Aston, R. Buchholz, R. Mirams, P. Vella, M. Zee, B. McCarthy, D. Feder, L. Sung

Achievements and awards

  • Member, The Royal Australian Chemical Institute
  • Member, The Society of Bioinorganic Chemistry
  • Award, UQ Strategic Research Fellowship (2000)
  • Award, UQ Foundation Research Excellence Award (2007)
  • Award, ARC Future Fellowship (2012)

Featured publications

Publications by Gary Schenk

Researcher biography

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

Publications

Book Chapters (5)
Journal Articles (224)
Conference Papers (32)
Thesis (1)
Data Collections (3)

Book Chapters

Mitić, Nataša, Miraula, Manfredi, Selleck, Christopher, Hadler, Kieran S., Uribe, Elena, Pedroso, M. M. and Schenk, G. (2014). Catalytic mechanisms of metallohydrolases containing two metal ions. Metal-containing enzymes. (pp. 49-81) edited by Christo Z. Christov. Waltham, MA, United States: Academic Press. doi: 10.1016/bs.apcsb.2014.07.002
Smith, Sarah J., Hadler, Kieran S., Schenk, Gerhard, Hanson, Graeme R. and Mitic, Nataša (2010). Manganese Metalloproteins. Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes. (pp. 273-341) edited by Graeme Hanson and Lawrence Berliner. New York, USA: Springer. doi: 10.1007/978-1-4419-1139-1_9
Mitić, Nataša, Schenk, Gerhard and Hanson, Graeme R. (2009). Binuclear non-heme iron enzymes. High resolution EPR: applications to metalloenzymes and metals in medicine. (pp. 269-395) edited by Graeme Hanson and Lawrence Berliner. New York, NY, United States: Springer. doi: 10.1007/978-0-387-84856-3_7
Solomon, E. I., Neidig, M. L. and Schenk, G. (2004). Magnetic circular dichroism of paramagnetic species. Comprehensive coordination chemistry II: From biology to nanotechnology. (pp. 339-349) edited by J. A. McCleverty and T. J.Meyer. Oxford, U.K.: Elsevier/Pergamon. doi: 10.1016/B0-08-043748-6/01216-0
Candy, Judith, Nixon, Peter, England, Renee, Schenk, Gerhard, Koga, J. and Duggleby, Ronald (1996). Site-directed mutagenesis of E50, F496 and H113 in Zymomonas mobilis decarboxylase. Biochemistry and physiology of thiamin diphosphate enzymes . (pp. 82-102) Prien, Germany: A. and C. Intemann, Wissenschaftlicher .

Journal Articles

Wang, Jialing, Chen, Jie, Lv, Kemin, Gao, Zhen, Li, Jiahuang, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Structure-Guided Engineering Unveils Deeper Substrate Channel in Processive Endoglucanase EG5C-1 Contributing to Enhanced Catalytic Efficiency and Processivity. ACS Synthetic Biology. doi: 10.1021/acssynbio.4c00562
Joshi, Pallav, Krco, Stefan, Davis, Samuel J., Asser, Lachlan, Brück, Thomas, Soo, Rochelle M., Bodén, Mikael, Hugenholtz, Philip, Wilson, Liam A., Schenk, Gerhard and Morris, Marc T. (2024). Phage Anti-Pycsar Proteins Efficiently Degrade β-Lactam Antibiotics. Applied Biosciences, 3 (4), 438-449. doi: 10.3390/applbiosci3040028
Rocha, Raquel A., Wilson, Liam A., Schwartz, Brett D., Warden, Andrew C., Guddat, Luke W., Speight, Robert E., Malins, Lara, Schenk, Gerhard and Scott, Colin (2024). Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics. Catalysts, 14 (7) ARTN 399, 399. doi: 10.3390/catal14070399
Lv, Kemin, Li, Xiaozhou, Chen, Kequan, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering. ACS Catalysis, 14 (9), 6856-6867. doi: 10.1021/acscatal.4c01083
Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958
Dinda, Rupam, Mohanty, Monalisa, Wilson, Liam, Roy, Satabdi, Mohapatra, Deepika, Patra, Sushree Aradhana, Schenk, Gerhard, Pessoa, João Costa, Sasamori, Takahiro and Aurelien, Crochet (2024). Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity. Journal of Molecular Structure, 1308 138106, 138106. doi: 10.1016/j.molstruc.2024.138106
Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539
Teshima, Mariko, Sutiono, Samuel, Döring, Manuel, Beer, Barbara, Boden, Mikael, Schenk, Gerhard and Sieber, Volker (2024). Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades. ChemSusChem, 17 (4) e202301132, 1-13. doi: 10.1002/cssc.202301132
Huang, Xiao-Lan, Harmer, Jeffrey R., Schenk, Gerhard and Southam, Gordon (2024). Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology. Frontiers in Chemistry, 12 ARTN 1349020. doi: 10.3389/fchem.2024.1349020
Lv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303
Wang, Jialing, Huang, Zhuangzhuang, Xu, Haodong, Nian, Yong, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines. ChemSusChem, 17 (9) e202301735. doi: 10.1002/cssc.202301735
Walsh, Michael, Schenk, Gerhard and Schmidt, Susanne (2023). Realising the circular phosphorus economy delivers for sustainable development goals. npj Sustainable Agriculture, 1 (1) 2, 1-15. doi: 10.1038/s44264-023-00002-0
Cheah, Li Chen, Liu, Lian, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Vickers, Claudia E. and Sainsbury, Frank (2023). Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization. Advanced Science, 10 (32) e2303415, 1-10. doi: 10.1002/advs.202303415
Kurz, Julia L., Monteiro Pedroso, Marcelo, Richard, Emmanuelle, McGeary, Ross P. and Schenk, Gerhard (2023). Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorganic and Medicinal Chemistry Letters, 92 129387, 1-5. doi: 10.1016/j.bmcl.2023.129387
Krco, Stefan, Davis, Samuel J., Joshi, Pallav, Wilson, Liam A., Monteiro Pedroso, Marcelo, Douw, Andrew, Schofield, Christopher J., Hugenholtz, Philip, Schenk, Gerhard and Morris, Marc T. (2023). Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance. Frontiers in Chemistry, 11 1196073, 1196073. doi: 10.3389/fchem.2023.1196073
Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383
Cheah, Li Chen, Liu, Lian, Stark, Terra, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Sainsbury, Frank and Vickers, Claudia E. (2023). Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation. Metabolic Engineering, 77, 143-151. doi: 10.1016/j.ymben.2023.03.012
Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528
Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008
Jayasinghe-Arachchige, Vindi M., Serafim, Leonardo F., Hu, Qiaoyu, Ozen, Cihan, Moorkkannur, Sreerag N., Schenk, Gerhard and Prabhakar, Rajeev (2023). Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes. ACS Catalysis, 13 (5), 3131-3147. doi: 10.1021/acscatal.2c05758
Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140
Costa, Luel M.O., Reis, Iago S., Fernandes, Christiane, Marques, Marcelo M., Resende, Jackson A.L.C., Krenske, Elizabeth H., Schenk, Gerhard, Gahan, Lawrence R. and Horn, Adolfo (2023). Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand. Journal of Inorganic Biochemistry, 239 112064, 1-13. doi: 10.1016/j.jinorgbio.2022.112064
Wilson, Liam A., Pedroso, Marcelo M., Peralta, Rosely A., Gahan, Lawrence R. and Schenk, Gerhard (2023). Biomimetics for purple acid phosphatases: a historical perspective. Journal of Inorganic Biochemistry, 238 112061, 112061. doi: 10.1016/j.jinorgbio.2022.112061
Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x
Satta, Alessandro, Esquirol, Lygie, Ebert, Birgitta E., Newman, Janet, Peat, Thomas S., Plan, Manuel, Schenk, Gerhard and Vickers, Claudia E. (2022). Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase. The FEBS Journal, 289 (21), 6672-6693. doi: 10.1111/febs.16556
Cheah, L. C., Liu, L., Plan, M. R., Peng, B., Lu, Z., Schenk, G., Vickers, C. E. and Sainsbury, F. (2022). Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes. BioRxiv. doi: 10.1101/2022.11.24.517869
Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633
Lv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011
Ellis, Daniel J., Kerr, Edward D., Schenk, Gerhard and Schulz, Benjamin L. (2022). Metabolomics of non-saccharomyces yeasts in fermented beverages. Beverages, 8 (3) 41, 1-14. doi: 10.3390/beverages8030041
Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073
Bayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927
Paper, Michael, Glemser, Matthias, Haack, Martina, Lorenzen, Jan, Mehlmer, Norbert, Fuchs, Tobias, Schenk, Gerhard, Garbe, Daniel, Weuster-Botz, Dirk, Eisenreich, Wolfgang, Lakatos, Michael and Brueck, Thomas B. (2022). Efficient green light acclimation of the green algae Picochlorum sp. triggering geranylgeranylated chlorophylls. Frontiers in Bioengineering and Biotechnology, 10 885977. doi: 10.3389/fbioe.2022.885977
Ringel, Marion, Dimos, Nicole, Himpich, Stephanie, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Schenk, Gerhard, Loll, Bernhard and Brück, Thomas (2022). Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microbial Cell Factories, 21 (1) 64, 64. doi: 10.1186/s12934-022-01791-8
Melse, Okke, Sutiono, Samuel, Haslbeck, Magdalena, Schenk, Gerhard, Antes, Iris and Sieber, Volker (2022). Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratases. ChemBioChem, 23 (10) e202200088, e202200088. doi: 10.1002/cbic.202200088
Stroek, Rozanne, Wilson, Liam, Goracke, William, Kang, Taeuk, Vermue, Febe, Krco, Stefan, Mendels, Yonatan, Douw, Andrew, Morris, Marc, Knaven, Esmee G., Mitić, Nataša, Gutierrez, Maria C.R., Schenk, Elaine B., Clark, Alice, Garcia, David, Monteiro Pedroso, Marcelo and Schenk, Gerhard (2022). LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibiotics. Journal of Inorganic Biochemistry, 226 111637, 1-4. doi: 10.1016/j.jinorgbio.2021.111637
Low, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9
Wilson, Liam A., Knaven, Esmée G., Morris, Marc T., Monteiro Pedroso, Marcelo, Schofield, Christopher J., Brück, Thomas, Boden, Mikael, Waite, David W., Hugenholtz, Philip, Guddat, Luke and Schenk, Gerhard (2021). Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid. Antimicrobial Agents and Chemotherapy, 65 (10) e00936-21, e0093621. doi: 10.1128/aac.00936-21
Wang, Lijuan, Cao, Kun, Pedroso, Marcelo Monteiro, Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis. Journal of Biological Chemistry, 297 (5) 101262, 101262. doi: 10.1016/j.jbc.2021.101262
Feder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486
O'Hara, Ian M., Tanticharoen, Morakot, MacRae, Elspeth, Imbrogno, Anthony, Rossi, Teresa, Sieber, Volker, Schenk, Gerhard, Ann-Kathrin, Kaufmann, Lukic, Ivana and Satapoomin, Ukkrit (2021). Land and sea: addressing the challenges facing inter-regional ecosystems in developing a sustainable bioeconomy. EFB Bioeconomy Journal, 1 100017, 1-4. doi: 10.1016/j.bioeco.2021.100017
Lv, Kemin, Yu, Zhimeng, Pedroso, Marcelo M., Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Metal affinity immobilization of the processive endoglucanase EG5C-1 from Bacillus subtilis on a recyclable pH-responsive polymer. ACS Sustainable Chemistry and Engineering, 9 (23) acssuschemeng.1c02215, 7948-7959. doi: 10.1021/acssuschemeng.1c02215
Pedroso, Marcelo Monteiro, Hine, Damian, Hahn, Sebastian, Chmielewicz, Wioleta Monika, Diegel, Janika, Gahan, Lawrence and Schenk, Gerhard (2021). Pesticide degradation by immobilised metalloenzymes provides an attractive avenue for bioremediation. EFB Bioeconomy Journal, 1 100015, 1-8. doi: 10.1016/j.bioeco.2021.100015
Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665
Lv, Kemin, Shao, Wenyu, Pedroso, Marcelo Monteiro, Peng, Jiayu, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2021). Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesis. International Journal of Biological Macromolecules, 168, 442-452. doi: 10.1016/j.ijbiomac.2020.12.060
Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919
Gomes, Marco Antonio G. B., Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo (2021). Recent advances in heterogeneous catalytic systems containing metal ions for phosphate ester hydrolysis. Chemistry: A European Journal, 27 (3) chem.202002333, 877-887. doi: 10.1002/chem.202002333
Silva, Marcos P., Saibert, Cristine, Bortolotto, Tiago, Bortoluzzi, Adailton J., Schenk, Gerhard, Peralta, Rosely A., Terenzi, Hernán and Neves, Ademir (2020). Dinuclear copper(II) complexes with derivative triazine ligands as biomimetic models for catechol oxidases and nucleases. Journal of Inorganic Biochemistry, 213 111249, 111249. doi: 10.1016/j.jinorgbio.2020.111249
Selleck, Christopher, Pedroso, Marcelo Monteiro, Wilson, Liam, Krco, Stefan, Knaven, Esmée Gianna, Miraula, Manfredi, Mitić, Nataša, Larrabee, James A., Brück, Thomas, Clark, Alice, Guddat, Luke W. and Schenk, Gerhard (2020). Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms. Scientific Reports, 10 (1) 12882, 12882. doi: 10.1038/s41598-020-68612-z
Wun, Shun Jie, Johnson, Lambro A., You, Lv, McGeary, Ross P., Brueck, Thomas, Schenk, Gerhard and Guddat, Luke W. (2020). Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Archives of Biochemistry and Biophysics, 692 108516, 108516. doi: 10.1016/j.abb.2020.108516
Ringel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
Awad, Dania, Younes, Samer, Glemser, Matthias, Wagner, Franz M., Schenk, Gerhard, Mehlmer, Norbert and Brueck, Thomas (2020). Towards high-throughput optimization of microbial lipid production: from strain development to process monitoring. Sustainable Energy and Fuels, 4 (12), 5958-5969. doi: 10.1039/d0se00540a
Pedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4
Wilson, Liam A., Garcia, David, Pedroso, Marcelo Monteiro, Schulz, Benjamin L., Guddat, Luke W. and Schenk, Gerhard (2020). Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction. Analytical Biochemistry, 595 113618, 113618. doi: 10.1016/j.ab.2020.113618
Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899
Sutiono, Samuel, Teshima, Mariko, Beer, Barbara, Schenk, Gerhard and Sieber, Volker (2020). Enabling the direct enzymatic dehydration of d-Glycerate to pyruvate as the key step in synthetic enzyme cascades used in the cell-free production of fine chemicals. ACS Catalysis, 10 (5), 3110-3118. doi: 10.1021/acscatal.9b05068
Sharma, Gaurav, Jayasinghe-Arachchige, Vindi M., Hu, Qiaoyu, Schenk, Gerhard and Prabhakar, Rajeev (2020). Effect of chemically distinct substrates on the mechanism and reactivity of a highly promiscuous metallohydrolase. ACS Catalysis, 10 (6), 3684-3696. doi: 10.1021/acscatal.9b04847
Feder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2020). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. Plant Science, 294 110445, 110445. doi: 10.1016/j.plantsci.2020.110445
Saswati, Mohanty, Monalisa, Banerjee, Atanu, Biswal, Sonaleen, Horn, Adolfo, Schenk, Gerhard, Brzezinski, Krzysztof, Sinn, Ekkehard, Reuter, Hans and Dinda, Rupam (2020). Polynuclear zinc(II) complexes of thiosemicarbazone: synthesis, X-ray structure and biological evaluation. Journal of Inorganic Biochemistry, 203 110908, 110908. doi: 10.1016/j.jinorgbio.2019.110908
Uribe, Elena, Reyes, María-Belen, Martínez, Ignacio, Mella, Kelly, Salas, Mónica, Tarifeño-Saldivia, Estefanía, López, Vasthi, García-Robles, María, Martínez-Oyanedel, José, Figueroa, Maximiliano, Carvajal, Nelson and Schenk, Gerhard (2020). Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective. Journal of Inorganic Biochemistry, 202 110812, 110812. doi: 10.1016/j.jinorgbio.2019.110812
Imran, Muhammad, Javed, Tariq, Jabeen, Asma, Mehnaz, Gul, Ullah, Kalim, Shaheen, Nusrat, Khalid, Sofia, Amirzada, Muhammad Imran, Yameen, Muhammad Arafat, Hasan, S. M. Farid, Shah, Sajid Hussain, Rauf, Khalid, Schenk, Gary, McGeary, Ross, Pieters, Luc, Latif, Muhammad, Al-Kahraman, Yasser Msa and Hassan Bin Asad, Muhammad Hassham (2020). Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents. Pakistan Journal of Pharmaceutical Sciences, 33 (1 Supplement), 385-392. doi: 10.36721/PJPS.2020.33.1.SUP.385-392.1
Mostert, A. Bernardus, Rienecker, Shermiyah B., Sheliakina, Margarita, Zierep, Paul, Hanson, Graeme R., Harmer, Jeffrey R., Schenk, Gerhard and Meredith, Paul (2020). Engineering proton conductivity in melanin using metal doping. Journal of Materials Chemistry B, 8 (35), 8050-8060. doi: 10.1039/d0tb01390k
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611
Parac-Vogt, Tatjana N., Erxleben, Andrea, Schenk, Gerhard and Prabhakar, Rajeev (2019). Editorial: Advances in the development of artificial metalloenzymes. Frontiers in Chemistry, 7 599, 599. doi: 10.3389/fchem.2019.00599
Pereira, Claudia, Farias, Giliandro, Maranha, Filipy G., Castilho, Nathalia, Schenk, Gerhard, de Souza, Bernardo, Terenzi, Hernán, Neves, Ademir and Peralta, Rosely A. (2019). Guanidine- and purine-functionalized ligands of FeIIIZnII complexes: effects on the hydrolysis of DNA. Journal of Biological Inorganic Chemistry, 24 (5), 675-691. doi: 10.1007/s00775-019-01680-3
Feder, Daniel, Gahan, Lawrence R., McGeary, Ross P., Guddat, Luke W. and Schenk, Gerhard (2019). The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state. ChemBioChem, 20 (12), 1536-1540. doi: 10.1002/cbic.201900077
Wu, Bin, Yu, Qi, Chang, Siyuan, Pedroso, Marcelo Monteiro, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2019). Expansin assisted bio-affinity immobilization of endoxylanase from Bacillus subtilis onto corncob residue: characterization and efficient production of xylooligosaccharides. Food Chemistry, 282, 101-108. doi: 10.1016/j.foodchem.2019.01.004
Enculescu, Charmaine, Kerr, Edward D., Yeo, K. Y. Benjamin, Schenk, Gerhard, Fortes, Marina R. S. and Schulz, Benjamin L. (2019). Proteomics reveals profound metabolic changes in the alcohol use disorder brain. ACS Chemical Neuroscience, 10 (5), 2364-2373. doi: 10.1021/acschemneuro.8b00660
Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019). Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 (5) e00704, e00704. doi: 10.1002/mbo3.704
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019). Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 (1), 61-71. doi: 10.1039/c8md00491a
Sharma, Gaurav, Hu, Qiaoyu, Jayasinghe-Arachchige, Vindi M., Paul, Thomas J., Schenk, Gerhard and Prabhakar, Rajeev (2019). Investigating coordination flexibility of glycerophosphodiesterase (GpdQ) through interactions with mono-, di-, and triphosphoester (NPP, BNPP, GPE, and paraoxon) substrates. Physical Chemistry Chemical Physics, 21 (10), 5499-5509. doi: 10.1039/c8cp07031h
Costal, Rafael O., Ferreira, Sarah S., Pereira, Crystiane A., Harmer, Jeffrey R., Noble, Christopher J., Schenk, Gerhard, Franco, Roberto W. A., Resende, Jackson A. L. C., Comba, Peter, Roberts, Asha E., Fernandes, Christiane and Horn Jr, Adolfo (2018). A new mixed-valence Mn(II)Mn(III) compound with catalase and superoxide dismutase activities. Frontiers in Chemistry, 6 (NOV) 491, 491. doi: 10.3389/fchem.2018.00491
Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5
Horn, Adolfo, Englert, Daniel, Roberts, Asha E., Comba, Peter, Schenk, Gerhard, Krenske, Elizabeth H. and Gahan, Lawrence R. (2018). Synthesis, magnetic properties, and catalytic properties of a nickel(II)-dependent biomimetic of metallohydrolases. Frontiers in Chemistry, 6 441, 441. doi: 10.3389/fchem.2018.00441
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018). Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157, 462-479. doi: 10.1016/j.ejmech.2018.08.004
Paul, Thomas J., Schenk, Gerhard and Prabhakar, Rajeev (2018). Formation of catalytically active binuclear center of glycerophosphodiesterase: a molecular dynamics study. The Journal of Physical Chemistry Part B, 122 (22), 5797-5808. doi: 10.1021/acs.jpcb.8b02046
Benítez, José, García, David, Romero, Nicol, González, Arlette, Martinez-Oyanedel, José, Figueroa, Maximiliano, Salas, Mónica, López, Vasthi, Garcia-Robles, Maria, Dodd, Peter R., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2018). Metabolic strategies for the degradation of the neuromodulator agmatine in mammals. Metabolism, 81, 35-44. doi: 10.1016/j.metabol.2017.11.005
Sidjabat, Hanna E., Gien, Jolene, Kvaskoff, David, Ashman, Keith, Vaswani, Kanchan, Reed, Sarah, McGeary, Ross P., Paterson, David L., Bordin, Amanda and Schenk, Gerhard (2018). The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure. Scientific Reports, 8 (1) 3871, 3871. doi: 10.1038/s41598-018-21984-9
Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 (2) e02280-17. doi: 10.1128/AAC.02280-17
Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2
Patel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017). Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry- A European Journal, 23 (72), 18289-18295. doi: 10.1002/chem.201704481
Camargo, Tiago Pacheco, Neves, Ademir, Peralta, Rosely A., Chaves, Cláudia, Maia, Elene C. P., Lizarazo-Jaimes, Edgar H., Gomes, Dawidson A., Bortolotto, Tiago, Norberto, Douglas R., Terenzi, Hernán, Tierney, David L. and Schenk, Gerhard (2017). Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity Properties. Inorganic Chemistry, 57 (1), 187-203. doi: 10.1021/acs.inorgchem.7b02384
Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203
Pedroso, Marcelo Monteiro, Selleck, Christopher, Enculescu, Charmaine, Harmer, Jeffrey R., Mitic, Natasa, Craig, Whitney R., Helweh, Waleed, Hugenholtz, Philip, Tyson, Gene W., Tierney, David L., Larrabee, James A. and Schenk, Gerhard (2017). Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics, 9 (8), 1157-1168. doi: 10.1039/c7mt00195a
Pedroso, Marcelo M., Ely, Fernanda, Carpenter, Margaret C., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Wilcox, Dean E. and Schenk, Gerhard (2017). Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Biochemistry, 56 (26), 3328-3336. doi: 10.1021/acs.biochem.6b01200
Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013
McGeary, Ross P., Tan, Daniel T. C., Selleck, Christopher, Monteiro Pedroso, Marcelo, Sidjabat, Hanna E. and Schenk, Gerhard (2017). Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor. European Journal of Medicinal Chemistry, 137, 351-364. doi: 10.1016/j.ejmech.2017.05.061
Monteiro Pedroso, Marcelo, Selleck, Christopher, Bilyj, Jessica, Harmer, Jeffrey R. , Gahan, Lawrence R. , Mitić, Natasa, Standish, Alistair J. , Tierney, David L. , Larrabee, James A. and Schenk, Gerhard (2017). Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents. Dalton Transactions, 46 (39), 13194-13201. doi: 10.1039/c7dt01350g
McGeary, Ross P., Tan, Daniel T. C. and Schenk, Gerhard (2017). Progress toward inhibitors of metallo-β-lactamases. Future Medicinal Chemistry, 9 (7), 673-691. doi: 10.4155/fmc-2017-0007
Comba, Peter, Eisenschmidt, Annika, Gahan, Lawrence R., Herten, Dirk-Peter , Nette, Geoffrey, Schenk, Gerhard and Seefeld, Martin (2017). Is CuII coordinated to patellamides inside Prochloron cells?. Chemistry - A European Journal, 23 (50), 12264-12274. doi: 10.1002/chem.201700895
Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866
Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028
Hou, Chun-Feng D., Liu, Jian-wei, Collyer, Charles, Mitić, Natasha, Pedroso, Marcelo Monteiro, Schenk, Gerhard and Ollis, David L. (2017). Insights into an evolutionary strategy leading to antibiotic resistance. Scientific Reports, 7 (1) 40357, 40357.1-40357.13. doi: 10.1038/srep40357
Romero, Nicol, Benitez, José, Garcia, David, Gonzalez, Arlette, Bennun, Leonardo, Garcia-Robles, María A., Lopez, Vasthi, Wilson, Liam A., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2017). Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases. Journal of Inorganic Biochemistry, 166, 122-125. doi: 10.1016/j.jinorgbio.2016.11.015
Selleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762
Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539
Schenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53.
Mendes, Luisa L., Englert, Daniel, Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo Jr. (2016). Metallohydrolase biomimetics with catalytic and structural flexibility. Dalton Transactions, 45 (46), 18510-18521. doi: 10.1039/c6dt03200a
Miraula, Manfredi, Schenk, Gerhard and Mitic, Natasa (2016). Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks. Journal of Inorganic Biochemistry, 162, 366-375. doi: 10.1016/j.jinorgbio.2015.12.014
Gahan, Lawrence, Comba, Peter, Schenk, Gerhard, Daumann, Lena, Hambley, Trevor and Berners-Price, Sue (2016). Preface. Journal of Inorganic Biochemistry, 162, 162-163. doi: 10.1016/j.jinorgbio.2016.09.011
Schenk, Gerhard, Mateen, Irsa, Ng, Tee-Kheang, Pedroso, Marcelo M., Mitic, Natasa, Jafelicci, Miguel, Marques, Rodrigo F. C., Gahan, Lawrence R. and Ollis, David L. (2016). Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediation. Coordination Chemistry Reviews, 317, 122-131. doi: 10.1016/j.ccr.2016.03.006
Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620
Arjomandi, Omid Khalili, Hussein, Waleed M., Vella, Peter, Yusof, Yusralina, Sidjabat, Hanna E., Schenk, Gerhard and McGeary, Ross P. (2016). Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1. European Journal of Medicinal Chemistry, 114, 318-327. doi: 10.1016/j.ejmech.2016.03.017
You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672
Brown, Joshua J., Gahan, Lawrence R., Schöffler, Anne, Krenske, Elizabeth H. and Schenk, Gerhard (2016). Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases. Journal of Inorganic Biochemistry, 162, 356-365. doi: 10.1016/j.jinorgbio.2016.02.008
Yusof, Yusralina, Tan, Daniel T. C., Arjomandi, Omid Khalili, Schenk, Gerhard and McGeary, Ross P. (2016). Captopril analogues as metallo-β-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (6), 1589-1593. doi: 10.1016/j.bmcl.2016.02.007
Bosch, Simone, Comba, Peter, Gahan, Lawrence R. and Schenk, Gerhard (2016). Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases. Journal of Inorganic Biochemistry, 162, 343-355. doi: 10.1016/j.jinorgbio.2015.12.028
Pedroso, Marcelo M., Larrabee, James A., Ely, Fernanda, Gwee, Shuhui E., Mitic, Natasa, Ollis, David L., Gahan, Lawrence R. and Schenk, Gerhard (2016). CaII binding regulates and dominates the reactivity of a transition-metal-ion-dependent diesterase from Mycobacterium tuberculosis. Chemistry - A European Journal, 22 (3), 999-1009. doi: 10.1002/chem.201504001
Fernandes, Christiane, Horn Jr, Adolfo, Lopes, Bruna F., Bull, Erika S., Azeredo, Nathália F., Kanashiro, Milton M., Borges, Franz V., Bortoluzzi, Adailton J., Szpoganicz, Bruno, Pires, Anderson B., Franco, Roberto W. A., de A. Almeida, João Carlos, Maciel, Leide L. F., Resende, Jackson A. L. C. and Schenk, Gerhard (2015). Induction of apoptosis in leukemia cell lines by new copper(II) complexes containing naphthyl groups via interaction with death receptors. Journal of Inorganic Biochemistry, 153, 68-87. doi: 10.1016/j.jinorgbio.2015.09.014
Rienecker, Shermiyah B., Mostert, A. Bernardus, Schenk, Gerhard, Hanson, Graeme R. and Meredith, Paul (2015). Heavy Water as a Probe of the Free Radical Nature and Electrical Conductivity of Melanin. Journal of Physical Chemistry B, 119 (48), 14994-15000. doi: 10.1021/acs.jpcb.5b08970
Bosch, Simone, Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Noble, Christopher, Schenk, Gerhard and Wadepohl, Hubert (2015). Selective coordination of gallium(III), zinc(II), and copper(II) by an asymmetric dinucleating ligand: a model for metallophosphatases. Chemistry - A European Journal, 21 (50), 18269-18279. doi: 10.1002/chem.201503348
Larrabee, James A., Schenk, Gerhard, Mitic, Natasa and Riley, Mark J. (2015). Use of magnetic circular dichroism to study dinuclear metallohydrolases and the corresponding biomimetics. European Biophysics Journal, 44 (6), 393-415. doi: 10.1007/s00249-015-1053-6
Bernhardt, Paul V., Bosch, Simone, Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Schenk, Gerhard and Wadepohl, Hubert (2015). An approach to more accurate model systems for purple acid phosphatases (PAPs). Inorganic Chemistry, 54 (15), 7249-7263. doi: 10.1021/acs.inorgchem.5b00628
Roberts, Asha E, Schenk, Gerhard and Gahan, Lawrence R (2015). A Heterodinuclear FeIIIZnII Complex as a Mimic for Purple Acid Phosphatase with Site-Specific ZnII Binding. European Journal of Inorganic Chemistry, 2015 (19), 3076-3086. doi: 10.1002/ejic.201500351
Ng, Tee-Kheang, Gahan, Lawrence R., Schenk, Gerhard and Ollis, David L. (2015). Altering the substrate specificity of methyl parathion hydrolase with directed evolution. Archives of Biochemistry and Biophysics, 573, 59-68. doi: 10.1016/j.abb.2015.03.012.
Quiñones, Matías, Cofre, Jaime, Benítez, José, García, David, Romero, Nicol, González, Arlette, Carvajal, Nelson, García, María, López, Vasthi, Schenk, Gerhard and Uribe, Elena (2015). Insight on the interaction of an agmatinase-like protein with Mn(2 +) activator ions. Journal of Inorganic Biochemistry, 145, 65-69. doi: 10.1016/j.jinorgbio.2015.01.008
Miraula, Manfredi, Enculescu, Charmaine, Schenk, Gerhard and Mitić, Nataša (2015). Inteins—A focus on the biotechnological applications of splicing-promoting proteins. American Journal of Molecular Biology, 05 (02), 42-56. doi: 10.4236/ajmb.2015.52005
Miraula, Manfredi, Whitaker, Jacob J, Schenk, Gerhard and Mitic, Natasa (2015). β-Lactam antibiotic-degrading enzymes from non-pathogenic marine organisms: a potential threat to human health. Journal of Biological Inorganic Chemistry, 20 (4), 639-651. doi: 10.1007/s00775-015-1250-x
Ribeiro, Thales P., Fernandes, Christiane, Melo, Karen V., Ferreira, Sarah S., Lessa, Josane A., Franco, Roberto W A., Schenk, Gerhard, Pereira, Marcos D. and Horn, Adolfo (2015). Iron, copper and manganese complexes with in vitro superoxide dismutase and/or catalase activities that keep Saccharomyces cerevisiae cells alive under severe oxidative stress. Free Radical Biology and Medicine, 80, 67-76. doi: 10.1016/j.freeradbiomed.2014.12.005
Guilfoyle, Amy P., Deshpande, Chandrika N., Font Sadurni, Josep, Ash, Miriam-Rose, Tourle, Samuel, Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, providing insight into the activation mechanism. Biophysical Journal, 107 (12), L45-L48. doi: 10.1016/j.bpj.2014.10.064
Guilfoyle, Amy P., Deshpande, Chandrika N., Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release. Bioscience Reports, 34 (6) e00158, 789-796. doi: 10.1042/BSR20140152
Tierney, David L. and Schenk, Gerhard (2014). X-ray absorption spectroscopy of dinuclear metallohydrolases. Biophysical Journal, 107 (6), 1263-1272. doi: 10.1016/j.bpj.2014.07.066
Bosch, Simone, Comba, Peter, Gahan, Lawrence R. and Schenk, Gerhard (2014). Dinuclear zinc(II) complexes with hydrogen bond donors as structural and functional phosphatase models. Inorganic Chemistry, 53 (17), 9036-9051. doi: 10.1021/ic5009945
Pedroso, Marcelo M., Ely, Fernanda, Mitic, Natasa, Carpenter, Margaret C., Gahan, Lawrence R., Wilcox, Dean E., Larrabee, James L., Ollis, David L. and Schenk, Gerhard (2014). Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH).. Journal of Biological Inorganic Chemistry, 19 (8), 1263-1275. doi: 10.1007/s00775-014-1183-9
Phelan, Emer K., Miraula, Manfred, Selleck, Christopher, Ollis, David L., Schenk, Gerhard and Mitic, Natasa (2014). Metallo-β-lactamases: a major threat to human health. American Journal of Molecular Biology, 4 (3), 89-104. doi: 10.4236/ajmb.2014.43011
Daumann, Lena J., Schenk, Gerhard and Gahan, Lawrence R. (2014). Metallo-beta-lactamases and their biomimetic complexes. European Journal of Inorganic Chemistry, 2014 (18), 2869-2885. doi: 10.1002/ejic.201402203
Fernandes, Christiane, Horn, Adolfo, Vieira-Da-Motta, Olney, Kanashiro, Milton M., Rocha, Michelle R., Moreira, Rafaela O., Morcelli, Samila R., Lopes, Bruna F., Mathias, Luciana da S., Borges, Franz V., Borges, Layla J. H., Freitas, William R., Visentin, Lorenzo C., Almeida, Joao C. de A. and Schenk, Gerhard (2014). Synthesis, characterization, antibacterial and antitumoral activities of mononuclear zinc complexes containing tridentate amine based ligands with N3 or N2O donor groups. Inorganica Chimica Acta, 416, 35-48. doi: 10.1016/j.ica.2014.02.040
Guilfoyle, Amy P., Deshpande, Chandrika N., Vincent, Kimberley, Pedroso, Marcelo M., Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate. FEBS Journal, 281 (9), 2254-2265. doi: 10.1111/febs.12779
McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014). The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76, 132-144. doi: 10.1016/j.ejmech.2014.02.008
Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014). Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 (3), 389-398. doi: 10.1007/s00775-013-1079-0
Hou, Chun-Feng D., Phelan, Emer K., Miraula, Manfredi, Ollis, David L., Schenk, Gerhard and Mitić, Nataša (2014). Unusual metallo-beta-lactamases may constitute a new subgroup in this family of enzymes. American Journal of Molecular Biology, 4 (1), 11-15. doi: 10.4236/ajmb.2014.41002
Daumann, Lena J., Larrabee, James A., Ollis, David, Schenk, Gerhard and Gahan, Lawrence R. (2014). Immobilization of the enzyme GpdQ on magnetite nanoparticles for organophosphate pesticide bioremediation. Journal of Inorganic Biochemistry, 131, 1-7. doi: 10.1016/j.jinorgbio.2013.10.007
Daumann, Lena J., Schenk, Gerhard, Ollis, David L. and Gahan, Lawrence R. (2014). Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes. Dalton Transactions, 43 (3), 910-928. doi: 10.1039/c3dt52287c
Horn, Adolfo, Jr., Fernandes, Christiane, Parrilha, Gabrieli L., Kanashiro, Milton M., Borges, Franz V., de Melo, Edesio J. T., Schenk, Gerhard, Terenzi, Hernan and Pich, Claus T. (2013). Highly efficient synthetic iron-dependent nucleases activate both intrinsic and extrinsic apoptotic death pathways in leukemia cancer cells. Journal of Inorganic Biochemistry, 128, 38-47. doi: 10.1016/j.jinorgbio.2013.07.019
Miraula, Manfredi, Brunton, Conor S., Schenk, Gerhard and Mitić, Nataša (2013). Identification and preliminary characterization of novel B3-type metallo-beta-lactamases. American Journal of Molecular Biology, 3 (4), 198-203. doi: 10.4236/ajmb.2013.34026
Vella, Peter, Miraula, Manfredi, Phelan, Emer, Leung, Eleanor W. W., Ely, Fernanda, Ollis, David L., McGeary, Ross P., Schenk, Gerhard and Mitić, Nataša (2013). Identification and characterization of an unusual metallo-beta-lactamase from Serratia proteamaculans. Journal of Biological Inorganic Chemistry, 18 (7), 855-863. doi: 10.1007/s00775-013-1035-z
Daumann, Lena J., Marty, Laurene, Schenk, Gerhard and Gahan, Lawrence R. (2013). Asymmetric zinc(II) complexes as functional and structural models for phosphoesterases. Dalton Transactions, 42 (26), 9574-9584. doi: 10.1039/c3dt50514f
Daumann, Lena J., Larrabee, James A., Comba, Peter, Schenk, Gerhard and Gahan, Lawrence R. (2013). Dinuclear cobalt(II) omplexes as metallo--lactamase mimics. European Journal of Inorganic Chemistry, 2013 (17), 3082-3089. doi: 10.1002/ejic.201300280
Dalle, Kristian E., Daumann, Lena J., Schenk, Gerhard, McGeary, Ross P., Hanton, Lyall R. and Gahan, Lawrence R. (2013). Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics. Polyhedron, 52, 1336-1343. doi: 10.1016/j.poly.2012.06.008
Daumann, Lena J., Comba, Peter, Larrabee, James A., Schenk, Gerhard, Stranger, Robert, Cavigiasso, German and Gahan, Lawrence R. (2013). Synthesis, magnetic properties, and phosphoesterase activity of dinuclear cobalt(II) complexes. Inorganic Chemistry, 52 (4), 2029-2043. doi: 10.1021/ic302418x
Schenk, Gerhard, Mitić, Nataša, Hanson, Graeme R. and Comba, Peter (2013). Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme. Coordination Chemistry Reviews, 257 (2), 473-482. doi: 10.1016/j.ccr.2012.03.020
Daumann, Lena J., McCarthy, Bianca Y., Hadler, Kieran S., Murray, Tracy P., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2013). Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1834 (1), 425-432. doi: 10.1016/j.bbapap.2012.02.004
Comba, Peter, Gahan, Lawrence R., Mereacre, Valeriu, Hanson, Graeme R., Powell, Annie K., Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model system. Inorganic Chemistry, 51 (22), 12195-12209. doi: 10.1021/ic301347t
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001
Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012). Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 (3-4), 168-179. doi: 10.1016/j.jmb.2012.09.018
Hussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012). Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 (4), 500-515. doi: 10.1111/j.1747-0285.2012.01440.x
Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012). Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 (9), 1593-1603. doi: 10.1021/ar300067g
Daumann, Lena J., Gahan, Lawrence R., Comba, Peter and Schenk, Gerhard (2012). Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamases. Inorganic Chemistry, 51 (14), 7669-7681. doi: 10.1021/ic300687y
Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123
Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Prisecaru, Ion, Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform. Chemistry: A European Journal, 18 (6), 1700-1710. doi: 10.1002/chem.201100229
Smith, Sarah J., Peralta, Rosely A., Jovito, Rafael, Horn, Adolfo, Bortoluzzi, Adailton J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Gahan, Lawrence R., Schenk, Gerhard, Nascimento, Otaciro R., Cavalett, Angelica, Bortolotto, Tiago, Razzera, Guilherme, Terenzi, Hernan, Neves, Ademir and Riley, Mark J. (2012). Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage. Inorganic Chemistry, 51 (4), 2065-2078. doi: 10.1021/ic201711p
Daumann, Lena J., Dalle, Kristian E., Schenk, Gerhard, McGeary, Ross P., Bernhardt, Paul V., Ollis, David L. and Gahan, Lawrence R. (2012). The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics. Dalton Transactions, 41 (6), 1695-1708. doi: 10.1039/c1dt11187f
Faridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116
Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015
Mohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030
Yip, Sylvia H-C., Foo, Jee-Loon, Schenk, Gerhard, Gahan, Lawrence R., Carr, Paul D. and Ollis, David L. (2011). Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme. Protein Engineering Design and Selection, 24 (12), 861-872. doi: 10.1093/protein/gzr048
Ely, Fernanda, Hadler, Kieran S., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Plugis, Nicholas M., Russo, Marie T., Larrabee, James A. and Schenk, Gerhard (2011). Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA). Journal of Biological Inorganic Chemistry, 16 (5), 777-787. doi: 10.1007/s00775-011-0779-6
Vella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027
Mohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024
Zee, Yoke Leng Michelle, Gahan, Lawrence R. and Schenk, Gerhard (2011). A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies. Australian Journal of Chemistry, 64 (3), 258-264. doi: 10.1071/CH10424
Ugwumba, Isaac N., Ozawa, Kiyoshi, de la Cruz, Laura, Xu, Zhi-Qiang, Herlt, Anthony J., Hadler, Kieran S., Coppin, Chris, Brown, Susan E., Schenk, Gerhard, Oakeshott, John G. and Otting, Gottfried (2011). Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.. ASSAY and Drug Development Technologies, 9 (1), 50-57. doi: 10.1089/adt.2010.0306
Ugwumba, Isaac N., Ozawa, Kiyoshi, Xu, Zhi-Qiang, Ely, Fernanda, Foo, Jee-Loon, Herlt, Anthony J., Coppin, Chris, Brown, Sue, Taylor, Matthew C., Ollis, David L., Mander, Lewis N., Schenk, Gerhard, Dixon, Nicholas E., Otting, Gottfried, Oakeshott, John G. and Jackson, Colin J. (2011). Improving a natural enzyme activity through incorporation of unnatural amino acids. Journal of The American Chemical Society, 133 (2), 326-333. doi: 10.1021/ja106416g
Kantacha, A, Buchholz, R, Smith, SJ, Schenk, G and Gahan, LR (2011). Phosphate ester cleavage promoted by a tetrameric iron(III) complex. Journal of Biological Inorganic Chemistry, 16 (1), 25-32. doi: 10.1007/s00775-010-0696-0
Peralta, RA, Bortoluzzi, AJ, de Souza, B, Jovito, R, Xavier, FR, Couto, RAA, Casellato, A, Nome, F, Dick, A, Gahan, LR, Schenk, G, Hanson, GR, de Paula, FCS, Pereira-Maia, EC, Machado, SD, Severino, PC, Pich, C, Bortolotto, T, Terenzi, H, Castellano, EE, Neves, A and Riley, MJ (2010). Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activity. Inorganic Chemistry, 49 (24), 11421-11438. doi: 10.1021/ic101433t
Vella, Peter, McGeary, Ross P., Gahan, Lawrence R. and Schenk, Gerhard (2010). Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeutics. Current Enzyme Inhibition, 6 (3), 118-129. doi: 10.2174/157340810793384133
Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054
Schenk, Gerhard (2010). Paradigm shift for the purple acid phosphatase reaction mechanism. Chemistry Australia, 77 (7), 9-9.
Foo, Jee‑Loon, Jackson, Colin J., Carr, Paul D., Kim, Hye‑Kyung, Schenk, Gerhard, Gahan, Lawrence R. and Ollis, David L. (2010). Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme. Biochemical Journal, 429 (2), 313-321. doi: 10.1042/BJ20100233
Mitic, Natasa, Hadler, Kieran S., Gahan, Lawrence R., Hengge, Alvan C. and Schenk, Gerhard (2010). The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. Journal of the American Chemical Society, 132 (20), 7049-7054. doi: 10.1021/ja910583y
Hadler, Kieran S., Mitic, Natasa, Yip, Sylvia Hsu-Chen, Gahan, Lawrence R., Ollis, David L., Schenk, Gerhard and Larrabee, James A. (2010). Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Inorganic Chemistry, 49 (6), 2727-2734. doi: 10.1021/ic901950c
Neves, Ademir, Bortoluzzi, Adailton J., Jovito, Rafael, Peralta, Rosely A., de Souza, Bernardo, Szpoganicz, Bruno, Joussef, Antônio C., Terenzi, Hernán, Severino, Patricia C., Fischer, Franciele L., Schenk, Gerhard, Riley, Mark J., Smith, Sarah J. and Gahan, Lawrence R. (2010). Catalytic promiscuity: Catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence Fe(III)Fe(II) complex. Journal of the Brazilian Chemical Society, 21 (7), 1201-1212. doi: 10.1590/S0103-50532010000700007
Jackson, C. J., Foo, J.-L., Tokuriki, N., Afriat, L., Carr, P. D., Kim, H.-K., Schenk, G., Tawfik, D. S. and Ollis, D. L. (2009). Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase. Proceedings of the National Academy of Sciences, 106 (51), 21631-21636. doi: 10.1073/pnas.0907548106
Schenk, G., Ollis, D. L., Hanson, G. R. and Gahan, L. R. (2009). Flexible and promiscuous!. Chemistry in Australia, 76 (10), 10-11.
Hadler, Kieran S., Gahan, Lawrence R., Ollis, David L. and Schenk, Gerhard (2009). The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis. Journal of Inorganic Biochemistry, 104 (2), 211-213. doi: 10.1016/j.jinorgbio.2009.10.012
Sarah Sarah J., Riley, Mark J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Schenk, Gerhard and Gahan, Lawrence R. (2009). Structural and catalytic characterization of a heterovalent Mn(II)Mn(III) complex that mimics purple acid phosphatases. Inorganic Chemistry, 48 (21), 10036-10048. doi: 10.1021/ic9005086
Hadler, Kieran S., Mitic, Natasa, Ely, Fernanda, Hanson, Graeme R., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2009). Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis. Journal of the American Chemical Society, 131 (33), 11900-11908. doi: 10.1021/ja903534f
Xavier, Fernando R., Neves, Ademir, Casellato, Annelise, Peralta, Rosely A., Bortoluzzi, Adailton J., Szpoganicz, Bruno, Severino, Patricia C., Terenzi, Hernan, Tomkowicz, Zbigniew, Ostrovsky, Sergei, Haase, Wolfgang, Ozarowski, Andrew, Krzystek, Jerzy, Telser, Joshua, Schenk, Gerhard and Gahan, Lawrence R. (2009). Unsymmetrical FeIIICoIII and GaIIICoII complexes as chemical hydrolases: Biomimetic models for purple acid phosphatases (PAPs). Inorganic Chemistry, 48 (16), 7905-7921. doi: 10.1021/ic900831q
Mitić, Nataša, Noble, Christopher J., Gahan, Lawrence R., Hanson, Graeme R. and Schenk, Gerhard (2009). Metal-ion mutagenesis: Conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site. Journal of the American Chemical Society, 131 (23), 8173-8179. doi: 10.1021/ja900797u
Gahan, Lawrence R., Smith, Sarah J., Neves, Ademir and Schenk, Gerhard (2009). Phosphate ester hydrolysis: Metal complexes as purple acid phosphatase and phosphotriesterase analogues. European Journal of Inorganic Chemistry, 2009 (19), 2745-2758. doi: 10.1002/ejic.200900231
Lessa, Josane A., Horn, Adolfo Jr., Bull, Érika S., Rocha, Michelle R., Benassi, Mario, Catharino, Rodrigo R., Eberlin, Marcos N., Casellato, Annelise, Noble, Christopher J., Hanson, Graeme R., Schenk, Gerhard, Silva, Giselle C., Antunes, O. A. C. and Fernandes, Christiane (2009). Catalase vs peroxidase activity of a manganese(II) compound: Identification of a Mn(III)-(mu-O)(2)-Mn(IV) reaction intermediate by electrospray ionization mass spectrometry and electron paramagnetic resonance spectroscopy. Inorganic Chemistry, 48 (10), 4569-4579. doi: 10.1021/ic801969c
Schenk, Gerhard (2009). GpdQ: a clever enzymatic bioremediator. Chemistry in Australia, 76 (1), 32-33.
Hanson, G. R., Gahan, L. R. and Schenk, G. (2009). Metal ion mutagenesis - how the replacement of metal ions can alter the properties of a metalloenzyme. Chemistry in Australia, 76 (8), 8-8.
McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009). Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 (1), 163-166. doi: 10.1016/j.bmcl.2008.10.125
Hadler, K., Tanifum, E.A., Yip, S.H.-C., Mitic, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A. and Schenk, G. (2008). Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 (43), 14129-14138. doi: 10.1021/ja803346w
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78
Jackson, Colin J., Hadler, Kieran S., Carr, Paul D., Oakley, Aaron J., Yip, Sylvia, Schenk, Gerhard and Ollis, David L. (2008). Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 64 (8), 681-685. doi: 10.1107/S1744309108017600
Mirams, Ruth E., Smith, Sarah J., Hadler, Kieran S., Ollis, David L., Schenk, Gerhard and Gahan, Lawrence R. (2008). Cadmium(II) complexes of the glycerophosphodiester-degrading enzyme GpdQ and a biomimetic N,O ligand. Journal of Biological Inorganic Chemistry, 13 (7), 1065-1072. doi: 10.1007/s00775-008-0392-5
Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008). Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6) 6, 1-13. doi: 10.1186/1472-6807-8-6
Smith, Sarah J., Noble, Christopher J., Palmer, Randahl C., Hanson, Graeme R., Schenk, Gerhard, Gahan, Lawrence R. and Riley, Mark J. (2008). Structural and spectroscopic studies of a model for catechol oxidase. Journal of Biological Inorganic Chemistry, 13 (4), 499-510. doi: 10.1007/s00775-007-0334-7
Buchholz, Rebecca R., Etienne, Morgan E., Dorgelo, Anneke, Mirams, Ruth E., Smith, Sarah J., Chow, Shiao Yun, Hanton, Lyall R., Jameson, Geoffrey B., Schenk, Gerhard and Gahan, Lawrence R. (2008). A structural and catalytic model for zinc phosphoesterases. Dalton Transactions, 2008 (43), 6045-6054. doi: 10.1039/b806391e
Ely, F., Foo, J. L., Jackson, C. J., Gahan, L. R., Ollis, D. L. and Schenk, G. (2008). Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases. Current Topics in Biochemical Research, 2008 (9), 63-78.
Schenk, Gerhard, Peralta, Rosely A., Batista, Suzana Cimara, Bortoluzzi, Adailton J., Szpoganicz, Bruno, Dick, Andrew K., Herrald, Paul, Hanson, Graeme R., Szilagyi, Robert K., Riley, Mark J., Gahan, Lawrence R. and Neves, Ademir (2008). Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics. Journal of Biological Inorganic Chemistry, 13 (1), 139-155. doi: 10.1007/s00775-007-0305-z
Boudalis, Athanassios K., Aston, Robyn E., Smith, Sarah J., Mirams, Ruth E., Riley, Mark J., Schenk, Gerhard, Blackman, Allan G., Hanton, Lyall R. and Gahan, Lawrence R. (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases. Dalton Transactions, 2007 (44), 5132-5139. doi: 10.1039/b709293h
Smith, S. J., Casellato, A., Hadler, K. S., Mitic, N., Riley, M. J., Bortoluzzi, A. J., Szpoganicz, B., Schenk, G., Neves, A. and Gahan, L. R. (2007). The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics. Journal of Biological Inorganic Chemistry, 12 (8), 1207-1220. doi: 10.1007/s00775-007-0286-y
Cox, R. S., Schenk, G., Mitic, N., Gahan, L. R. and Hengge, A. C. (2007). Diesterase activity and substrate binding in purple acid phosphatases. Journal of The American Chemical Society, 129 (31), 9550-9551. doi: 10.1021/ja072647q
Liu, J. W., Hadler, K. S., Schenk, G. and Ollis, D. (2007). Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability. FEBS Journal, 274 (18), 4742-4751. doi: 10.1111/j.1742-4658.2007.06022.x
Neidig, M., Wecksler, A., Schenk, G., Holman, T. and Solomon, E. (2007). Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme. Journal of the American Chemical Society, 129 (24), 7531-7537. doi: 10.1021/ja068503d
Neves, A., Lanznaster, M., Bortoluzzi, A. J., Peralta, R. A., Casellato, A., Castellano, E. E., Herrald, P., Riley, M. J. and Schenk, G. (2007). An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases. Journal of The American Chemical Society, 129 (24), 7486-7487. doi: 10.1021/ja071184l
Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007). Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8, 21-31.
Schenk, Gerhard (2007). Binuclear metallohydrases : emerging drug targets. Chemistry in Australia, 74 (8), 32-33.
Jackson, Colin J., Carr, Paul D., Kim, Hye-Kyung, Liu, Jian-Wei, Herrald, Paul, Mitic, Natasa, Schenk, Gerhard, Smith, Clyde A. and Ollis, David L. (2006). Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site. Biochemical Journal, 397 (3), 501-508. doi: 10.1042/BJ20060276
Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W. and Schenk, G. (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Journal of the Brazilian Chemical Society, 17 (8), 1558-1565. doi: 10.1590/S0103-50532006000800011
Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006). The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 (8), 3338-3363. doi: 10.1021/cr050318f
De Jersey, J., Zheng, Yuan-Zhi, Fan, H. K., Schenk, G., Guddat, L. and Hamilton, S. (2006). Mammalian-like purple acid phosphatases in plants. Chemical Research In Chinese Universities, 22 (2), 263-264. doi: 10.1016/S1005-9040(06)60093-7
Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031
Lanznaster, Mauricio, Neves, Ademir, Bortoluzzi, Adailton J., Aires, Veronika V. E., Szpoganicz, Bruno, Terenzi, Hernan, Severino, Patricia C., Fuller, Julie M., Drew, Simon C., Gahan, Lawrence R., Hanson, Graeme R., Riley, Mark J. and Schenk, Gerhard (2005). A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases. Journal of Biological Inorganic Chemistry, 10 (4), 319-332. doi: 10.1007/s00775-005-0635-7
Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., de Jersey, J. and Guddat, L. W. (2005). Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proceedings of The National Academy of Sciences of The United States of America, 102 (2), 273-278. doi: 10.1073/pnas.0407239102
Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005). Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 (2), 154-164. doi: 10.1016/j.abb.2005.05.013
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008
Bernhardt, P. V., Schenk, G. and Wilson, G. J. (2004). Direct electrochemistry of porcine purple acid phosphatase (uteroferrin). Biochemistry, 43 (32), 10387-10392. doi: 10.1021/bi0490338
Schenk, G., Pau, M. Y. M. and Solomon, E. I. (2004). Comparison between the geometric and electronic structures and reactivities of {FeNO}(7) and {FeO2}(8) complexes: A density functional theory study. Journal of The American Chemical Society, 126 (2), 505-515. doi: 10.1021/ja036715u
Mitic, N., Saleh, L., Schenk, G., Bollinger, J. Martin Jr. and Solomon, E. I. (2003). Rapid-freeze-quench magnetic circular dichroism of intermediate X in ribonucleotide reductase: New structural insight. Journal of The American Chemical Society, 125 (37), 11200-11201. doi: 10.1021/ja036556e
Schenk, Gerhard, Neidig, Michael L., Zhou, Jing, Holman, Theodore R. and Solomon, Edward I. (2003). Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity. Biochemistry, 42 (24), 7294-7302. doi: 10.1021/bi027380g
Twitchett, M. B., Schenk, G., Aquino, M. A. S., Yiu, D. T. Y., Lau, T. C. and Sykes, A. G. (2002). Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate. Inorganic Chemistry, 41 (22), 5787-5794. doi: 10.1021/ic020037f
Schenk, Gerhard, Boutchard, Clare L., Carrington, Lyle E., Noble, Christopher J., Moubaraki, Boujemaa, Murray, Keith S., de Jersey, John, Hanson, Graeme R. and Hamilton, Susan (2001). A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center. Journal of Biological Chemistry, 276 (22), 19084-19088. doi: 10.1074/jbc.M009778200
Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9
Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X
Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4
Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999). Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 (12), 2051-2052. doi: 10.1107/S0907444999012597
Schenk, G., Ge, Y., Carrington, L., Wynne, C. J., Searle, I. R., Carroll, B. J., Hamilton, S. E. and De Jersey, J. (1999). Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean. Archives of Biochemistry and Biophysics, 370 (2), 183-189. doi: 10.1006/abbi.1999.1407
Schenk, G, Duggleby, RG and Nixon, PF (1998). Heterologous expression of human transketolase. International Journal of Biochemistry and Cell Biology, 30 (3), 369-378. doi: 10.1016/S1357-2725(97)00154-4
Schenk, G, Duggleby, RG and Nixon, PF (1998). Properties and functions of the thiamin diphosphate dependent enzyme transketolase. International Journal of Biochemistry and Cell Biology, 30 (12), 1297-1318. doi: 10.1016/S1357-2725(98)00095-8
Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis. European Journal of Biochemistry, 248 (1), 63-71. doi: 10.1111/j.1432-1033.1997.t01-1-00063.x
Schenk, G, Layfield, R, Candy, JM, Duggleby, RG and Nixon, PF (1997). Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. Journal of Molecular Evolution, 44 (5), 552-572. doi: 10.1007/PL00006179

Conference Papers

Cheng, Yan, Lonhienne, Thierry, Garcia, Mario, Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2023). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085571
Schenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, 31 July - 4 August 2017. New York, NY United States: Springer.
Enculescu, C. V., Ho, A. M. C., Rueda, A. V., Fortes, M. R. S., Shamsollahi, G., James, D. P., Schenk, G., Camarini, R., Dodd, P. R. and Stadlin, A. (2017). Polymorphisms in Gabra and Rgs Genes Are Associated with Alcoholism and a Secondary Diagnosis of Liver Cirrhosis: Results Are Sex-Linked. 40th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA), Denver CO, United States, 24-28 June 2017. Hoboken, NJ United States: Wiley.
Pedroso, M., Ely, F., Gahan, L. R., Schenk, G., Ollis, D. L. and Larrabee, J. A. (2014). Kinetics and Structural Analysis of Rv0805 from Mycobacterium tuberculosis. 16th International Conference on Biological Inorganic Chemistry (ICBIC), Grenoble France, 22-26 July 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00775-014-1095-8
Miraula, Manfredi, Schenk, Gerhard and Mitić, Nataša (2014). Characterization of novel metallo-beta-lactamases from the B3 subgroup. EuroBIC 12: 12th European Biological Inorganic Chemistry Conference, Zurich, Switzerland, 24-28 August, 2014. Heidelberg, Germany: Springer. doi: 10.1007/s00775-014-1164-z
Mitic, Natasa, Noble, Christopher, Gahan, Lawrence R., Hanson, Graeme R. and Schenk, Gerhard (Gary) (2010). Metal ion mutagenesis – conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site. EPR 2010. A Joint Conference of the 14th In Vivo ESR/EPR Spectroscopy & Imaging and the 11th International EPR Spin Trapping/Spin Labeling, San Juan, Puerto Rico, 2-6 May 2010.
Noble, Christopher, Mitic, Natasa, Park, Ah Young, Gahan, Lawrence R., Schenk, Gerhard, Dixon, Nicholas E. and Hanson, Graeme R. (2010). Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR spectroscopy. 7th Asia-Pacific EPR/ESR Symposium (APES2010), Jeju Island, Republic of Korea, 10-14 October 2010. Daegu, Republic of Korea: Asia-Pacific EPR/ESR Society.
Noble, Christopher J., Gahan, Lawrence R., Schenk, Gerhard and Hanson, Graeme R. (2010). Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR Spectroscopy. World Wide Magnetic Resonance 2010: Joint Euromar 2010 and 17th ISMAR Conference (WWMR2010 ), Florence, Italy, 4-9 July 2010. Florence, Italy: Worldwide Magnetic Resonance Conference.
Mitic, N., Noble, C. J., Dixon, N. E., Hanson, G. R. and Schenk, G. (2008). Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato. 6th Asia Pacific EPR/ESR Society Symposium, Cairns, Queensland, Australia, 13-18 July 2008.
Smith, S., Noble, C. J., Hanson, G. R., Riley, M., Schenk, G. and Gahan, L. R. (2008). Spectroscopic and catalytic properties of uteroferrin and related model systems. 6th Asia Pacific EPR/ESR Symposium, Cairns, Queensland, Australia, 13-18 July 2008.
Schenk, G., Mitic, N., Gahan, L., Smith, S. and Hadler, K. (2008). Binuclear metallohydrolases: emerging bioremediators and drug targets. 9th European Biological Inorganic Chemistry Conference, Wroclaw, Poland, 2-6 Spetember 2008. Italy: Medimond.
Noble, Christopher J., Smith, S. J., Mitic, N., Schenk, G., Casselto, A. and Hanson, Graeme R. (2008). Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes. 6th Asia Pacific EPR/ESR Symposium, Cairns, Australia, 13-18 July 2008. St Lucia, Australia: Asia Pacific EPR Society.
Dick, A., Gahan, L. R., Hanson, G., Krausz, E. R., Neves, A., Riley, M. J. and Schenk, G. (2007). Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase. CPC2007: The 6th RACI Conference on Physical Chemistry, Adelaide, South Australia, 28 January - 2 February, 2007.
Gahan, Lawrence R., Hadler, Kieran S., Larrabee, James A., Riley, Mark J. and Schenk, Gerhard (2007). Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0256-4
Aston, Robyn, Boudalis, Athanassios K., Gahan, Lawrence R., Riley, Mark J., Sanakis, Yiannis and Schenk, Gerhard (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0258-2
Mitic, N., Park, A. Y., Dixon, N., Hanson, G. R. and Schenk, G. (2006). Substrate analogue induced formation of a binuclear centre in the proof reading 3'-5' exonuclease (e) Subunit of Escherichia coli DNA polymerase III. 6th Biennial ANZMAG Conference 2006, Murramarang Resort, Murramarang National Park, N.S.W., 12-16 February 2006. Randwick, NSW: ANZMAG.
Smith, S J, Casselato, A., Mitic, N, Riley, M J, Neves, A., Schenk, G and Gahan, L R (2006). GA(III) as an analogue of FE(III) in purple acid phosphatases and related model compounds. 37th Int Conference on Coordination Chemistry, Cape Town, 13-18 Aug, 2006.
Herrald, P. R., Drew, S. C., Neves, A., Murray, K. S., Moubaraki, B., Mitic, N., Riley, M. J., Hanson, G R, Gahan, L. R. and Schenk, G. (2006). Biomimetics and a derivative of pig purple acid phosphatase with FeIIINiII binuclear centres. 8th European Biological Inorganic Chemistry Conference (EUROBIC 8), Aveiro, Portugal, 2-6 July, 2006.
Elliott, Tristan W., Mitić, Nataša, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Sociedade Brasileira de Quimica. doi: 10.1590/S0103-50532006000800011
Mitic, Natasa, Herrald, Paul, Drew, Simon C., Gahan, Lawrence R., Riley, Mark J., Neves, Ademir, Schenk, Gerhard and Hanson, Graeme R. (2005). Characterization of Novel Metal Centers in Purple Acid Phosphatases and Related Model Complexes. 12th International Conference on Biological Inorganic Chemistry, University of Michigan, Department of Chemistry, Ann Arbor, MI, July 31- August 5, 2005.
Dick, A. K., Riley, M. J., Krausz, E. R. and Schenk, G. (2005). Magnetic circular dichroism spectroscopy of a bimetallic purple acid phosphatase mimic. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, 3-7 July 2005. Melbourne, Vic., Australia: Royal Australian Chemical Institute (RACI).
Smith, S. J., Gahan, L. R., Schenk, G. and Riley, M. J. (2005). Model complexes of purple acid phosphatases. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, 3-7 July 2005. Melbourne, Vic., Australia: Royal Australian Chemical Institute (RACI).
Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.
Noble, C. J., Hanson, G. R. and Schenk, G. (2000). The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins. ANZMAG 2000, Mt Buller, Vic, 13-17 February 2000. Melbourne, Vic: ANZMAG.
Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. EUROBIC-5, Toulouse, France, 17-20 July 2000.
Hanson, G. R., Schenk, G. and Noble, C. J. (2000). Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins. 42nd Rocky Mountain Conference on Analytical Chemistry, Broomfield, Colorado, USA, 30 July - 3 August, 2000. USA: Milestone Presentations.
Schenk, G., Carrington, L., Hanson, G. R., De Jersey, J. and Hamilton, S. E. (1999). Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre. Specialist Meeting on Enzyme Structure and Mechanism, Kurong Resort, Fraser Island, 22-25 September, 1999. Brisbane: Univ. of Qld.
Hanson, G. R., Noble, C. J., Boutchard, C., Schenk, G., Hamilton, S. E. and De Jersey, J. (1999). Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening. 2nd Asia-Pacific EPR/ESR Symposium Proceedings, Hangzhou, China, 31 October - 4 November 1999. China: Asia Pacific EPR/ESR Society.
Hanson, G. R., Noble, C. J., Schenk, G., Hamilton, S. E., Boutchard, C. and De Jersey, J. (1999). Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening. 41st Rocky Mountain Conference on Analytical Chemistry, Denver, 1st - 5th August, 2000. Denver: American Chemical Society.
Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.
Boutchard, C.L., Carrington, L., Schenk, G., Noble, C.J., Hanson, G.R., Hamilton, S.E., de Jersey, J. and Gahan, L.R. (1998). Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy. A joint 29th AMPERE — 13th ISMAR International Conference on Magnetic Resonance and Related Phenomena Revisited, Berlin, Germany, 2-7 August, 1998. Berlin, Germany: Springer Wien. doi: 10.1007/BF03162015
Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). Investigation of the mechanistic functions of residues HIS113 and HIS114 in pyruvate decarboxylase from Zymomonas mobilis: A proposed model in the binding of the substrate pyruvate. Unknown, Unknown, Unknown. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.

Thesis

Schenk, Gerhard (1997). Studies on the thiamin-dependent enzymes transketolase and pyruvate decarboxylase. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/7bd3260

Data Collections

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genomic resources of seven Australian weed species of national significance. The University of Queensland. (Dataset) doi: 10.48610/c22c10c
Cheah, Li Chen, Vickers, Claudia, Sainsbury, Frank, Cheah, Li Chen, Sainsbury, Frank, Schenk, Gary and Vickers, Claudia (2022). Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes. The University of Queensland. (Dataset) doi: 10.48610/eab4972
Cheah, Li Chen, Vickers, Claudia, Sainsbury, Frank, Cheah, Li Chen, Sainsbury, Frank, Schenk, Gary and Vickers, Claudia (2022). SR-SIM raw data - GFP and mRuby3 co-encapsulation. The University of Queensland. (Dataset) doi: 10.48610/cf92aa5