Highlighted papers


Guillerey, C., Huntington, N.D., Smyth, M.J. (2016) Targeting natural killer cells in cancer immunotherapy, Nature Immunology 17: 1025-1036.

Bryant, J.M., Grogono, D.M, Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C.J.W., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jonsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., van Ingen, J., Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., Floto, R.A. (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science 354: 751-757.

Navarro, S., Pickering, D.A., Ferreira, I.B., Jones, L., Ryan, S., Troy, S., Leech, A., Hotez, P.J., Zhan, B., Laha, T., Prentice, R., Sparwasser, T., Croese, J., Engwerda, C.R.Upham, J.W., Julia, V., Giacomin, P.R., Loukas, A. (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine 8: 362ra143.

Hall, R.A., Macdonald, J. (2016) Synthetic biology provides a toehold in the fight against Zika. Cell Host Microbe 19: 752-754.

Trembizki, E., Guy, R., Donovan, B., Kaldor, J.M., Lahra, M.M., Whiley, D.M. (2016) Further evidence to support the individualised treatment of gonorrhoea with ciprofloxacin. Lancet Infectious Diseases 16: 1005-1006.

Paterson, D.L., Harris, P.N.A. (2016) Colistin resistance: a major breach in our last line of defence. Lancet Infectious Diseases 16: 132-133.

Stubenrauch, C., Belousoff, M.J., Hay, I.D., Shen, H.H., Lillington, J., Tuck, K.L., Peters, K.M., Phan, M.D., Lo, A.W., Schembri, M.A., Strugnell, R.A., Waksman, G., Lithgow, T. (2016) Less Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nature Microbiology 7: 16064.



Coll, R.C., Robertson, A.A.B., Chae, J.J., Higgins, S.C., Munoz-Planillo, R., Inserra, M.C., Vetter, I., Dungan, L.S., Monks, B.G., Stutz, A., Croker, D.E., Butler, M.S., Haneklaus, M., Sutton, C.E., Nunez, G., Latz, E., Kastner, D.L., Mills, K.H.G., Masters, S.L., Schroder, K.Cooper, M.A., O'Neill, L.A.J. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21: 248-255.

Zuegg, J., Muldoon, C., Adamson, G., McKeveney, D., Le Thanh, G., Premraj, R., Becker, B., Cheng, M., Elliott, A.G., Huang, J.X., Butler, M.S., Bajaj, M., Seifert, J., Singh, L., Galley, N.F., Roper, D.I, Lloyd, A.J., Dowson, C.G., Cheng, T.J., Cheng, W.C., Demon, D., Meyer, E., Meutermans, W., Cooper, M.A. (2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications 6: 7719.

Cooper, M.A. (2015) A community-based approach to new antibiotic discovery. Nature Reviews Drug Discovery 14: 587-588.

Davies, M.R., Holden, M.T., Coupland, P., Chen, J.H.K., Venturini, C., Barnett, T.C., Ben Zakour, N., Tse, H., Dougan, G., Yuen, K.Y., Walker, M.J. (2015) Emergence of scarlet fever Streptococcus pyogenes M12 clones in Hong Kong is associated with toxin acquisition and multi-drug resistance. Nature Genetics 47: 84-87.

Teng, M.W.L, Bowman, E.P., McElwee, J.J., Smyth, M.J., Casanova, J.L., Cooper, A.M., Cua, D.J. (2015) IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nature Medicine 21: 719-729.

Zowawi, H.M., Harris, P.N.A., Roberts, M.J., Tambyah, P.A., Schembri, M.A., Pezzani, M.D., Williamson, D.A, Paterson, D.L. (2015) The emerging threat of multidrug-resistant Gram-negative bacteria in urology. Nature Reviews Urology 12: 570-584.

Martinet, L., Smyth, M.J. (2015) Balancing natural killer cell activation through paired receptors. Nature Reviews Immunology 15: 243-254.

Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M.J., Kroemer, G. (2015) Type I interferons in anticancer immunity. Nature Reviews Immunology 15: 405-414.

Modhiran, N., Watterson, D., Muller, D.A., Panetta, A.K., Sester, D.P., Liu, L.D., Hume, D.A., Stacey, K.J.Young, P.R. (2015) Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine 7: 304ra142.

Wainwright, C.E., Elborn, J.S., Ramsey, B.W., Marigowda, G., Huang, X., Cipolli, M., Colombo, C., Davies, J.C., De Boeck, K., Flume, P.A., Konstan, M.W., McColley, S.A., Mccoy, K., McKone, E.F., Munck, A., Ratjen, F., Rowe, S.M., Waltz, D., Boyle, M.P. (2015) Lumacaftor-Ivacaftor in patients with cystic Fibrosis homozygous for Phe508del CFTR. New England Journal of Medicine 373: 220-231.

Rampatige, R., Gilks, C.F. (2015) Autopsies and better data on causes of death in Africa. Lancet Infectious Diseases 15: 492-494.

Harris, P.N.A., Tambyah, P.A., Paterson, D.L. (2015) Beta-lactam and beta-lactamase inhibitor combinations in the treatment of extended-spectrum beta-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options? Lancet Infectious Diseases 15: 475-485.

Schlapbach, L.J., Straney, L., Alexander, J., MacLaren, G., Festa, M., Schibler, A., Slater, A., (2015) Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study. Lancet Infectious Diseases 15: 46-54.



Corbett, A.J., Eckle, S.B., Birkinshaw, R.W., Liu, L., Patel, O., Mahony, J., Chen, Z., Reantragoon, R., Meehan, B., Cao, H., Williamson N.A., Strugnell, R.A, Van Sinderen, D., Mak, J.Y., Fairlie, D.P., Kjer-Nielsen, L., Rossjohn, J., McCluskey, J. (2014) T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature 509: 361-365.

Goire, N., Lahra, M.M., Chen, M., Donovan, B., Fairley, C.K., Guy, R., Kaldor, J., Regan, D., Ward, J., Nissen, M.D., Sloots, T.P., Whiley, D.M. (2014) Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nature Reviews Microbiology 12: 223-229. 

Counago, R.M., Ween, M.P., Begg, S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology 10: 35-66U. 

Dacunha, V., Davies, M.R., Douarre, P.E., Rosinski-Chupin, I., Margarit, I., Spinali, S., Perkins, T., Lechat, P., Dmytruk, N., Sauvage, E., Ma, L., Tichit, M., Lopez-Sanchez, M.J., Descorps-Declere, S., Buchrieser, C., Trieu-Cuot, P., Moszer, I., Clermont, D., Maione, D., Bouchier, C., McMillan, D.J., Parkhill, J., Telford, J.L., Dougan, G., Walker, M.J., The Devani Consortium, Holden, M.T.G., Poyart C., Glaser P. (2014) Streptococcus agalactiae clones infecting humans have been selected and fixed through the extensive use of tetracycline. Nature Communications 5: 4544. 

Milinovich, G.J., Williams, G.M., Clements, A.C.A., Hu, W.B. (2014) Internet-based surveillance systems for monitoring emerging infectious diseases. Lancet Infectious Diseases 14:160-168.

Beatson, S.A., Walker, M.J. (2014) Tracking antibiotic resistance. Science 345: 1454-1455.

van Sorge, N.M., Cole, J.N., Kuipers, K., Henningham, A., Aziz, R.K., Kasirer-Friede, A., Lin, L., Berends, E.T.M., Davies, M.R., Dougan, G., Zhang, F., Dahesh, S., Shaw, L., Gin, J., Cunningham, M., Merriman, J.A., Rooijakkers, S.H.M., Malley, R., Walker, M.J., Shattil, S.J., Schlievert, P.M., Choudhury, B, Nizet, V. (2014) The classical Lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host & Microbe 15: 729-740.



Clements, A.C.A., Reid, H.L., Kelly, G.C., Hay, S.I. (2013) Further shrinking the malaria map: how can geospatial science help to achieve malaria elimination? Lancet Infectious Diseases 13: 709-718.

Barnett, T.C., Liebl, D., Seymour, L.M., Gillen, C.M., LaRock, C.N., Davies, M.R., Schulz, B.L., Nizet, V., Teasdale, R.D., Walker, M.J. (2013) The group A Streptococcus M1T1 clone evades autophagy for intracellular replication. Cell Host & Microbe 14: 675-682.

Truong, N.P., Gu, W.Y., Prasadam, I., Jia, Z.F., Crawford, R., Xiao, Y., Monteiro, M.J. (2013) An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications 4: 1902.

Reid, R.C., Yau, M.K., Singh, R., Hamidon, J.K., Reed, A.N., Chu, P., Suen, J.Y., Stoermer, M.J., Blakeney, J.S., Lim, J., Faber, J.M., Fairlie, D.P. (2013) Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications 4: 3802.



Mahalingam, S, Herrero, L.J., Playford, E.G., Spann, K.M., Herring, B., Rolph, M.S., Middleton, D., McCall, B., Field, H., Wang, L.F. (2012) Hendra virus: an emerging paramyxovirus in Australia. Lancet Infectious Diseases 12: 799-807.

Richmond, P.C., Marshall, H.S., Nissen, M.D., Jiang, Q., Jansen, K.U., Garcés-Sánchez, M., Martinón-Torres, F., Beeslaar, J., Szenborn, L., Wysocki, J., Eiden, J., Harris, S.L., Jones, T.R., Perez, J.L. (2012) Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2 trial. Lancet Infectious Diseases 12: 597–607.

Selkrig J., Mosbahi K., Webb C.T., Belousoff M.J., Perry A.J., Wells T.J., Morris F., Leyton D.L., Totsika M., Phan M.D., Celik N., Kelly M., Oates C., Hartland E.L., Robins-Browne R.M., Ramarathinam S.H., Purcell A.W., Schembri M.A., Strugnell R.A., Henderson I.R., Walker D., Lithgow T. (2012) Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural & Molecular Biology 19: 506-510.

Holt, P.G., Sly, P.D. (2012) Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nature Medicine 18: 726-735. 

Walker, M.J., Beatson, S.A. (2012) Outsmarting outbreaks. Science 338: 1039-1040. 



Ramsey, B.W., Davies, J., McElvaney N.G., Tullis, E., Bell, S.C., Dřevínek, P., Griese, M., McKone, E., Wainwright, C., Konstan, M., Moss, R., Ratjen, F., Sermet-Gaudelus, I., Rowe, S.M., Dong, Q., Rodriguez, S., Yen, K., Ordoñez, C., Elborn, J.S. on behalf of the VX08-770-102 Study Group. (2011) A CFTR potentiator in patients with cystic fibrosis and the G551D Mutation. New England Journal of Medicine 365: 1663-1672.

Deng, Z.J., Liang, M.T., Monteiro, M., Toth, I., Minchin, R.F. (2011) Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 (CD11b/CD18) receptor activation and inflammation. Nature Nanotechnology 6: 39-44.

Cole, J.N., Barnett, T.C., Nizet, V., Walker, M.J. (2011) Molecular insight into group A streptococcal invasive disease. Nature Reviews Microbiology 9: 1-13.

Gavidia, T., Brune, M.N., McCarty, K.M., Pronczuk, J., Etzel, R., Neira, M., Carpenter, D.O., Suk, W.A., Arnold, R.G., Ha, E.H., Sly, P.D. (2011) Children's environmental health - from knowledge to action. Lancet 377: 1134-1136.

Cooper, M.A., Shlaes, D.A. (2011) Fix the antibiotics pipeline. Nature 472: 32.