Highlighted papers

2017:

Rutledge, G.G., Bohme, U., Sanders, M., Rrid, A.J., Cotton, J.A., Maiga-Ascofare, O., Djimde, A.A., Apinjoh, T.O., Amenga-Etego, L., Manske, M., Barnwell, J.W., Renaud, F., Ollomo, B., Prugnolle, F., Anstey, N.M., Auburn, S., Price, R.N., McCarthy, J.S., Kwiatkowski, D.P., Newbold, C.I., Berriman, M., Otto, T.D. (2017) Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution. Nature 542: 10.1038/nature21038

Chen, W.Q., Foo, S.S., Zaid, A., Teng, T.S., Herrero, L.J., Wolf, S., Tharmarajah, K., Vu, L.D., van Vreden, C., Taylor, A., Freitas, J.R., Li, R.W., Woodruff, T.M., Gordon, R., Ojcius, D.M., Nakaya, H.I., Kanneganti, T.D., O'Neill, L.A.J., Robertson, A.A.B., King, N.J., Suhrbier, A., Cooper, M.A., Ng, L.F.P., Mahalingam, S. (2017) Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology 2: 10.1038/s41564-017-0015-4

Lohman, R.J., Hamidon, J.K., Reid, R.C., Rowley, J.A., Yau, M.K., Halili, M.A., Nielsen, D.S., Lim, J., Wu, K.C., Loh, Z., Do, A., Suen, J.Y., Iyer, A., Fairlie, D.P. (2017) Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications 8: 10.1038/s41467-017-00414-w.

Furlong, E.J., Lo, A.W., Kurth, F., Premkumar, L., Totsika, M., Achard, M.E.S., Halili, M.A., Heras, B., Whitten, A.E., Choudhury, H.G., Schembri, M.A., Martin, J.L. (2017) A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance. Nature Communications 8: 10.1038/ncomms16065.

Adema, C.M., Hillier, L.W., Jones, C.S., Loker, E.S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L.R., Arican-Goktas, H.D., Assis, J.G., Baba, E.H., Baron, O.L., Bayne, C.J., Bickham-Wright, U., Biggar, K.K., Blouin, M., Bonning, B.C., Botka, C., Bridger, J.M., Buckley, K.M., Buddenborg, S.K., Caldeira, R.L., Carleton, J., Carvalho, O.S., Castillo, M.G; Chalmers, I.W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R.M., Cuesta-Astroz, Y., Cummins, S.F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., FitzGerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S.G., Geusz, M., Geyer, K.K., Giraldo-Calderon, G.I., Gomes, M.D., Gordy, M.A., Gourbal, B., Grunau, C., Hanington, P.C. Hoffmann, K.F., Hughes, D., Humphries, J., Jackson, D.J., Jannotti-Passos, L.K., Jeremias, W.D., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J.M., Kohn, A.B., Lawson, D., Lawton, S.P., Liang, D., Limpanont, Y., Liu, S.J., Lockyer, A.E., Lovato, T.L., Ludolf, F., Magrini, V., McManus, D.P., Medina, M., Misra, M., Mitta, G., Mkoji, G.M., Montague, M.J., Montelongo, C., Moroz, L.L., Munoz-Torres, M.C., Niazi, U., Noble, L.R., Oliveira, F.S., Pais, F.S., Papenfuss, A.T., Peace, R., ; Pena, J.J., Pila, E.A., Quelais, T., Raney, B.J., Rast, J.P., Rollinson, D., Rosse, I.C., Rotgans, B., Routledge, E.J., Ryan, K.M., Scholte, L.L.S., Storey, K.B., Swain, M., Tennessen, J.A., Tomlinson, C., Trujillo, D.L., Volpi, E.V., Walker, A.J., Wang, T., Wannaporn, I., Warren, W.C., Wu, X.J., Yoshino, T.P., Yusuf, M., Zhang, S.M., Zhao, M., Wilson, R.K. (2017) Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8: 10.1038/ncomms15451.

Wang, J.P., Yu, Y., Shen, H.M., Qing, T., Zheng, Y.T., Li, Q., Mo, X.J., Wang, S.Q., Li, N.N., Chai, R.Y., Xu, B., Liu, M., Brindley, P.J., McManus, D.P., Feng, Z., Shi, L.M., Hu, W. (2017) Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum. Nature Communications 8: 10.1038/ncomms14693.

Kerr, M.C., Gomez, G.A., Ferguson, C., Tanzer, M.C., Murphy, J.M., Yap, A.S., Parton, R.G., Huston, W.M., Teasdale, R.D. (2017) Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis Nature Communications 8: 10.1038/ncomms14729.

Cao, M.D., Nguyen, S.H., Ganesamoorthy, D., Elliott, A.G., Cooper, M.A., Coin, L.J.M. (2017) Scaffolding and completing genome assemblies in real-time with nanopore sequencing. Nature Communications 8: 10.1038/ncomms14515.

Luo, L., Bokil, N.J., Wall, A.A., Kapetanovic, R., Lansdaal, N.M., Marceline, F., Burgess, B.J., Tong, .SJ., Guo, Z., Alexandrov, K., Ross, I.L., Hibbs, M.L., Stow, J.L., Sweet, M.J. (2017) SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications 8: 10.1038/ncomms14133.

Zhang, P., Lee, .S., Gartlan, K.H., Schuster, I.S., Comerford, I., Varelias, A., Ullah, A., Vuckovic, S., Koyama, M., Kuns, R.D., Locke, K.R., Beckett, K.J., Olver, S.D., Samson, L.D., Montes de Oca, M., de Labastida Rivera, F., Clouston, A.D., Belz, G.T., Blazar, B.R., MacDonald, K.P., McColl, S.R., Thomas, R., Engwerda, C.R., Degli-Esposti, M.A., Kallies, A., Tey, S.K., Hill, G.R. (2017) Eomesodermin promotes the development of type 1 regulatory T (TR1) cells. Science Immunology 2: 10.1126/sciimmunol.aah7152.

McCarthy, J.S., Lotharius, J., Ruckle, T., Chalon, S., Phillips, M.A., Elliott, S., Sekuloski, S., Griffin, P., Ng, C.L., Fidock, D.A. (2017) Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study. Lancet Infectious Diseases 17: 626-635.

Paterson, D.L., van Duin, D. (2017) China's antibiotic resistance problems. Lancet Infectious Diseases 17: 351-352.

2016:

Guillerey, C., Huntington, N.D., Smyth, M.J. (2016) Targeting natural killer cells in cancer immunotherapy, Nature Immunology 17: 1025-1036.

Bryant, J.M., Grogono, D.M, Rodriguez-Rincon, D., Everall, I., Brown, K.P., Moreno, P., Verma, D., Hill, E., Drijkoningen, J., Gilligan, P., Esther, C.R., Noone, P.G., Giddings, O., Bell, S.C., Thomson, R., Wainwright, C.E., Coulter, C., Pandey, S., Wood, M.E., Stockwell, R.E., Ramsay, K.A., Sherrard, L.J., Kidd, T.J., Jabbour, N., Johnson, G.R., Knibbs, L.D., Morawska, L., Sly, P.D., Jones, A., Bilton, D., Laurenson, I., Ruddy, M., Bourke, S., Bowler, I.C.J.W., Chapman, S.J., Clayton, A., Cullen, M., Dempsey, O., Denton, M., Desai, M., Drew, R.J., Edenborough, F., Evans, J., Folb, J., Daniels, T., Humphrey, H., Isalska, B., Jensen-Fangel, S., Jonsson, B., Jones, A.M., Katzenstein, T.L., Lillebaek, T., MacGregor, G., Mayell, S., Millar, M., Modha, D., Nash, E.F., O'Brien, C., O'Brien, D., Ohri, C., Pao, C.S., Peckham, D., Perrin, F., Perry, A., Pressler, T., Prtak, L., Qvist, T., Robb, A., Rodgers, H., Schaffer, K., Shafi, N., van Ingen, J., Walshaw, M., Watson, D., West, N., Whitehouse, J., Haworth, C.S., Harris, S.R., Ordway, D., Parkhill, J., Floto, R.A. (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science 354: 751-757.

Navarro, S., Pickering, D.A., Ferreira, I.B., Jones, L., Ryan, S., Troy, S., Leech, A., Hotez, P.J., Zhan, B., Laha, T., Prentice, R., Sparwasser, T., Croese, J., Engwerda, C.R.Upham, J.W., Julia, V., Giacomin, P.R., Loukas, A. (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine 8: 362ra143.

Hall, R.A., Macdonald, J. (2016) Synthetic biology provides a toehold in the fight against Zika. Cell Host Microbe 19: 752-754.

Trembizki, E., Guy, R., Donovan, B., Kaldor, J.M., Lahra, M.M., Whiley, D.M. (2016) Further evidence to support the individualised treatment of gonorrhoea with ciprofloxacin. Lancet Infectious Diseases 16: 1005-1006.

Paterson, D.L., Harris, P.N.A. (2016) Colistin resistance: a major breach in our last line of defence. Lancet Infectious Diseases 16: 132-133.

Stubenrauch, C., Belousoff, M.J., Hay, I.D., Shen, H.H., Lillington, J., Tuck, K.L., Peters, K.M., Phan, M.D., Lo, A.W., Schembri, M.A., Strugnell, R.A., Waksman, G., Lithgow, T. (2016) Less Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nature Microbiology 7: 16064.

 

 2015:

Coll, R.C., Robertson, A.A.B., Chae, J.J., Higgins, S.C., Munoz-Planillo, R., Inserra, M.C., Vetter, I., Dungan, L.S., Monks, B.G., Stutz, A., Croker, D.E., Butler, M.S., Haneklaus, M., Sutton, C.E., Nunez, G., Latz, E., Kastner, D.L., Mills, K.H.G., Masters, S.L., Schroder, K.Cooper, M.A., O'Neill, L.A.J. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21: 248-255.

Zuegg, J., Muldoon, C., Adamson, G., McKeveney, D., Le Thanh, G., Premraj, R., Becker, B., Cheng, M., Elliott, A.G., Huang, J.X., Butler, M.S., Bajaj, M., Seifert, J., Singh, L., Galley, N.F., Roper, D.I, Lloyd, A.J., Dowson, C.G., Cheng, T.J., Cheng, W.C., Demon, D., Meyer, E., Meutermans, W., Cooper, M.A. (2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications 6: 7719.

Cooper, M.A. (2015) A community-based approach to new antibiotic discovery. Nature Reviews Drug Discovery 14: 587-588.

Davies, M.R., Holden, M.T., Coupland, P., Chen, J.H.K., Venturini, C., Barnett, T.C., Ben Zakour, N., Tse, H., Dougan, G., Yuen, K.Y., Walker, M.J. (2015) Emergence of scarlet fever Streptococcus pyogenes M12 clones in Hong Kong is associated with toxin acquisition and multi-drug resistance. Nature Genetics 47: 84-87.

Teng, M.W.L, Bowman, E.P., McElwee, J.J., Smyth, M.J., Casanova, J.L., Cooper, A.M., Cua, D.J. (2015) IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nature Medicine 21: 719-729.

Zowawi, H.M., Harris, P.N.A., Roberts, M.J., Tambyah, P.A., Schembri, M.A., Pezzani, M.D., Williamson, D.A, Paterson, D.L. (2015) The emerging threat of multidrug-resistant Gram-negative bacteria in urology. Nature Reviews Urology 12: 570-584.

Martinet, L., Smyth, M.J. (2015) Balancing natural killer cell activation through paired receptors. Nature Reviews Immunology 15: 243-254.

Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M.J., Kroemer, G. (2015) Type I interferons in anticancer immunity. Nature Reviews Immunology 15: 405-414.

Modhiran, N., Watterson, D., Muller, D.A., Panetta, A.K., Sester, D.P., Liu, L.D., Hume, D.A., Stacey, K.J.Young, P.R. (2015) Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine 7: 304ra142.

Wainwright, C.E., Elborn, J.S., Ramsey, B.W., Marigowda, G., Huang, X., Cipolli, M., Colombo, C., Davies, J.C., De Boeck, K., Flume, P.A., Konstan, M.W., McColley, S.A., Mccoy, K., McKone, E.F., Munck, A., Ratjen, F., Rowe, S.M., Waltz, D., Boyle, M.P. (2015) Lumacaftor-Ivacaftor in patients with cystic Fibrosis homozygous for Phe508del CFTR. New England Journal of Medicine 373: 220-231.

Rampatige, R., Gilks, C.F. (2015) Autopsies and better data on causes of death in Africa. Lancet Infectious Diseases 15: 492-494.

Harris, P.N.A., Tambyah, P.A., Paterson, D.L. (2015) Beta-lactam and beta-lactamase inhibitor combinations in the treatment of extended-spectrum beta-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options? Lancet Infectious Diseases 15: 475-485.

Schlapbach, L.J., Straney, L., Alexander, J., MacLaren, G., Festa, M., Schibler, A., Slater, A., (2015) Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study. Lancet Infectious Diseases 15: 46-54.

 

2014:

Corbett, A.J., Eckle, S.B., Birkinshaw, R.W., Liu, L., Patel, O., Mahony, J., Chen, Z., Reantragoon, R., Meehan, B., Cao, H., Williamson N.A., Strugnell, R.A, Van Sinderen, D., Mak, J.Y., Fairlie, D.P., Kjer-Nielsen, L., Rossjohn, J., McCluskey, J. (2014) T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature 509: 361-365.

Goire, N., Lahra, M.M., Chen, M., Donovan, B., Fairley, C.K., Guy, R., Kaldor, J., Regan, D., Ward, J., Nissen, M.D., Sloots, T.P., Whiley, D.M. (2014) Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nature Reviews Microbiology 12: 223-229. 

Counago, R.M., Ween, M.P., Begg, S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology 10: 35-66U. 

Dacunha, V., Davies, M.R., Douarre, P.E., Rosinski-Chupin, I., Margarit, I., Spinali, S., Perkins, T., Lechat, P., Dmytruk, N., Sauvage, E., Ma, L., Tichit, M., Lopez-Sanchez, M.J., Descorps-Declere, S., Buchrieser, C., Trieu-Cuot, P., Moszer, I., Clermont, D., Maione, D., Bouchier, C., McMillan, D.J., Parkhill, J., Telford, J.L., Dougan, G., Walker, M.J., The Devani Consortium, Holden, M.T.G., Poyart C., Glaser P. (2014) Streptococcus agalactiae clones infecting humans have been selected and fixed through the extensive use of tetracycline. Nature Communications 5: 4544. 

Milinovich, G.J., Williams, G.M., Clements, A.C.A., Hu, W.B. (2014) Internet-based surveillance systems for monitoring emerging infectious diseases. Lancet Infectious Diseases 14:160-168.

Beatson, S.A., Walker, M.J. (2014) Tracking antibiotic resistance. Science 345: 1454-1455.

van Sorge, N.M., Cole, J.N., Kuipers, K., Henningham, A., Aziz, R.K., Kasirer-Friede, A., Lin, L., Berends, E.T.M., Davies, M.R., Dougan, G., Zhang, F., Dahesh, S., Shaw, L., Gin, J., Cunningham, M., Merriman, J.A., Rooijakkers, S.H.M., Malley, R., Walker, M.J., Shattil, S.J., Schlievert, P.M., Choudhury, B, Nizet, V. (2014) The classical Lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host & Microbe 15: 729-740.

 

2013:

Clements, A.C.A., Reid, H.L., Kelly, G.C., Hay, S.I. (2013) Further shrinking the malaria map: how can geospatial science help to achieve malaria elimination? Lancet Infectious Diseases 13: 709-718.

Barnett, T.C., Liebl, D., Seymour, L.M., Gillen, C.M., LaRock, C.N., Davies, M.R., Schulz, B.L., Nizet, V., Teasdale, R.D., Walker, M.J. (2013) The group A Streptococcus M1T1 clone evades autophagy for intracellular replication. Cell Host & Microbe 14: 675-682.

Truong, N.P., Gu, W.Y., Prasadam, I., Jia, Z.F., Crawford, R., Xiao, Y., Monteiro, M.J. (2013) An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications 4: 1902.

Reid, R.C., Yau, M.K., Singh, R., Hamidon, J.K., Reed, A.N., Chu, P., Suen, J.Y., Stoermer, M.J., Blakeney, J.S., Lim, J., Faber, J.M., Fairlie, D.P. (2013) Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications 4: 3802.

 

2012:

Mahalingam, S, Herrero, L.J., Playford, E.G., Spann, K.M., Herring, B., Rolph, M.S., Middleton, D., McCall, B., Field, H., Wang, L.F. (2012) Hendra virus: an emerging paramyxovirus in Australia. Lancet Infectious Diseases 12: 799-807.

Richmond, P.C., Marshall, H.S., Nissen, M.D., Jiang, Q., Jansen, K.U., Garcés-Sánchez, M., Martinón-Torres, F., Beeslaar, J., Szenborn, L., Wysocki, J., Eiden, J., Harris, S.L., Jones, T.R., Perez, J.L. (2012) Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2 trial. Lancet Infectious Diseases 12: 597–607.

Selkrig J., Mosbahi K., Webb C.T., Belousoff M.J., Perry A.J., Wells T.J., Morris F., Leyton D.L., Totsika M., Phan M.D., Celik N., Kelly M., Oates C., Hartland E.L., Robins-Browne R.M., Ramarathinam S.H., Purcell A.W., Schembri M.A., Strugnell R.A., Henderson I.R., Walker D., Lithgow T. (2012) Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural & Molecular Biology 19: 506-510.

Holt, P.G., Sly, P.D. (2012) Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nature Medicine 18: 726-735. 

Walker, M.J., Beatson, S.A. (2012) Outsmarting outbreaks. Science 338: 1039-1040. 

 

2011:

Ramsey, B.W., Davies, J., McElvaney N.G., Tullis, E., Bell, S.C., Dřevínek, P., Griese, M., McKone, E., Wainwright, C., Konstan, M., Moss, R., Ratjen, F., Sermet-Gaudelus, I., Rowe, S.M., Dong, Q., Rodriguez, S., Yen, K., Ordoñez, C., Elborn, J.S. on behalf of the VX08-770-102 Study Group. (2011) A CFTR potentiator in patients with cystic fibrosis and the G551D Mutation. New England Journal of Medicine 365: 1663-1672.

Deng, Z.J., Liang, M.T., Monteiro, M., Toth, I., Minchin, R.F. (2011) Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 (CD11b/CD18) receptor activation and inflammation. Nature Nanotechnology 6: 39-44.

Cole, J.N., Barnett, T.C., Nizet, V., Walker, M.J. (2011) Molecular insight into group A streptococcal invasive disease. Nature Reviews Microbiology 9: 1-13.

Gavidia, T., Brune, M.N., McCarty, K.M., Pronczuk, J., Etzel, R., Neira, M., Carpenter, D.O., Suk, W.A., Arnold, R.G., Ha, E.H., Sly, P.D. (2011) Children's environmental health - from knowledge to action. Lancet 377: 1134-1136.

Cooper, M.A., Shlaes, D.A. (2011) Fix the antibiotics pipeline. Nature 472: 32.